Compounds That Bind APP and Inhibit Aβ Processing in Vitro Suggest a Novel Approach to Alzheimer Disease Therapeutics

Autor: Espeseth, Amy S. ^‡, Xu, Min ^‡, Huang, Qian ^‡, Coburn, Craig A. ^§, Jones, Kristen L.G. ^§, Ferrer, Marc ^¶, Zuck, Paul D. ^¶, Strulovici, Berta ^¶, Price, Eric A. ^‡, Wu, Guoxin ^‡, Wolfe, Abigail L. ^‡, Lineberger, Janet E. ^‡, Sardana, Mohinder ^‡, Tugusheva, Katherine ^‡, Pietrak, Beth L. ^‡, Crouthamel, Ming-Chih ^‡, Lai, Ming-Tain ^‡, Dodson, Elizabeth Chen ^‡, Bazzo, Renzo ^∥, Shi, Xiao-Ping ^‡, Simon, Adam J. ^‡, Li, Yueming ^{‡, **}, Hazuda, Daria J. ^{‡, ‡‡}

Publikováno v: In Journal of Biological Chemistry 6 May 2005 280(18):17792-17797

High Throughput Monitoring of Amyloid-β42 Assembly into Soluble Oligomers Achieved by Sensitive Conformation State-Dependent Immunoassays.

Autor: Zhao, Wei-Qin, Toolan, Dawn, Hepler, Robert W., Wolfe, Abigail L., Yu, Yuanjiang, Price, Eric, Uebele, Victor N., Schachter, Joel B., Reynolds, Ian J., Renger, John J., McCampbell, Alexander, Ray, William J.

Publikováno v: Journal of Alzheimer's Disease; 2011, Vol. 25 Issue 4, p655-669, 15p, 1 Color Photograph, 1 Diagram, 4 Graphs

A novel assay for the DNA strand-transfer reaction of HIV-1 integrase.

Autor: Hazuda, Daria J., Hastings, Jeffrey C., Wolfe, Abigail L., Emini, Emilio A.

Publikováno v: Nucleic Acids Research; 3/15/1994, Vol. 22 Issue 6, p1121-1122, 2p

Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.

Autor: Zhuang L; Departments of Medicinal Chemistry, Antiviral Research, and Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. linghang_zhuang@merck.com, Wai JS, Embrey MW, Fisher TE, Egbertson MS, Payne LS, Guare JP Jr, Vacca JP, Hazuda DJ, Felock PJ, Wolfe AL, Stillmock KA, Witmer MV, Moyer G, Schleif WA, Gabryelski LJ, Leonard YM, Lynch JJ Jr, Michelson SR, Young SD

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2003 Feb 13; Vol. 46 (4), pp. 453-6.