Výsledky vyhledávání - "Wolfangel Craig Daniel"

Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor

Publikováno v: Journal of Medicinal Chemistry. 62:8711-8732

Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a353395d3c6f7ca6dfa78c95a347dd4
https://doi.org/10.1021/acs.jmedchem.9b01234

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Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners

Autor: William L. Elliott, Anthony D. Sercel, Alan J. Kraker, Boguslawa Leja, Charles W. Moore, David W. Fry, Andrew M. Thompson, Wolfangel Craig Daniel, Patrick W. Vincent, H. D. Hollis Showalter, Gina H. Lu, Bill J. Roberts, Curtis T. Howard, James M. Nelson, Linda A. Ambroso, William A. Denny

Publikováno v: Journal of medicinal chemistry. 40(4)

A small series of 2,2'-diselenobis(1H-indoles) was synthesized as redox-modified congeners of our earlier reported 2,2'-dithiobis(1H-indole) series. Utilizing chemistry similar to that developed earlier for the disulfur series, compounds were made fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa169b3ed4593faa06f23a6b4977a66
https://pubmed.ncbi.nlm.nih.gov/9046331

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