Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Wolf-Rainer Abraham"'
Autor:
Shuting Li, Chia-Wen Lu, Elia C. Diem, Wang Li, Melanie Guderian, Marc Lindenberg, Friederike Kruse, Manuela Buettner, Stefan Floess, Markus R. Winny, Robert Geffers, Hans-Hermann Richnow, Wolf-Rainer Abraham, Guntram A. Grassl, Matthias Lochner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here the authors report that inhibition of de novo fatty acid synthesis by deleting the enzyme Acetyl-CoA-Carboxylase 1 in the intestinal epithelium results in the loss of crypt structures and a specific decline in Lgr5+ intestinal epithelial stem ce
Externí odkaz:
https://doaj.org/article/7000115314134be5b8f02dfada5b3128
Publikováno v:
Journal of Fungi, Vol 9, Iss 7, p 726 (2023)
The two fungal human pathogens, Candida auris and Candida albicans, possess a variety of virulence mechanisms. Among them are the formation of biofilms to protect yeast against harsh conditions through the development of (pseudo)hyphae whilst also fa
Externí odkaz:
https://doaj.org/article/75ef3ceb2b7640b696df9cf2567464cd
Autor:
Diana Fortkamp Grigoletto, Ana Maria Lima Correia, Wolf-Rainer Abraham, Andre Rodrigues, Marco Antonio Assis, Antonio Gilberto Ferreira, Michelli Massaroli, Simone Possedente de Lira
Publikováno v:
Acta Scientiarum: Biological Sciences, Vol 41, Pp e48785-e48785 (2019)
Fungi are present in the most diverse environments including the interior of plant tissues, living as endophytes without causing apparent damage. These endophytes are producers of secondary metabolites, also known as natural products, such as fungici
Externí odkaz:
https://doaj.org/article/83972b2ae3594ee18d5ce90864a9746a
Autor:
Kamila Tomoko Yuyama, Thaís Souto Paula da Costa Neves, Marina Torquato Memória, Iago Toledo Tartuci, Wolf-Rainer Abraham
Publikováno v:
AIMS Microbiology, Vol 3, Iss 1, Pp 50-60 (2017)
Infections where pathogens are organized in biofilms are difficult to treat due to increased antibiotic resistances in biofilms. To overcome this limitation new approaches are needed to control biofilms. One way is to screen natural products from org
Externí odkaz:
https://doaj.org/article/7aeb275cc65a49dabb22563c021acd8c
Publikováno v:
Antibiotics, Vol 9, Iss 11, p 788 (2020)
Infections involving biofilms are difficult to treat due to increased resistances against antibiotics and the immune system. Hence, there is an urgent demand for novel drugs against biofilm infections. During our search for novel biofilm inhibitors f
Externí odkaz:
https://doaj.org/article/abf34764d6b34d68a0286cfa36285c67
Autor:
Philipp Stüve, Lucía Minarrieta, Hanna Erdmann, Catharina Arnold-Schrauf, Maxine Swallow, Melanie Guderian, Freyja Krull, Alexandra Hölscher, Peyman Ghorbani, Jochen Behrends, Wolf-Rainer Abraham, Christoph Hölscher, Tim D. Sparwasser, Luciana Berod
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, is able to efficiently manipulate the host immune system establishing chronic infection, yet the underlying mechanisms of immune evasion are not fully understood. Evidence s
Externí odkaz:
https://doaj.org/article/8f8f910f03db44969c21545058c3b1ac
Autor:
Sebastian Felgner, Michael Frahm, Dino Kocijancic, Manfred Rohde, Denitsa Eckweiler, Agata Bielecka, Emilio Bueno, Felipe Cava, Wolf-Rainer Abraham, Roy Curtiss, Susanne Häussler, Marc Erhardt, Siegfried Weiss
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT Recombinant attenuated Salmonella enterica serovar Typhimurium strains are believed to act as powerful live vaccine carriers that are able to elicit protection against various pathogens. Auxotrophic mutations, such as a deletion of aroA, are
Externí odkaz:
https://doaj.org/article/b28681446d39498e87e4324eb3ecfd84
Autor:
Kamila Tomoko Yuyama, Lucile Wendt, Frank Surup, Robin Kretz, Clara Chepkirui, Kathrin Wittstein, Chollaratt Boonlarppradab, Sarunyou Wongkanoun, Jennifer Luangsa-ard, Marc Stadler, Wolf-Rainer Abraham
Publikováno v:
Biomolecules, Vol 8, Iss 4, p 129 (2018)
During the course of our ongoing work to discover new inhibitors of biofilm formation of Staphylococcus aureus from fungal sources, we observed biofilm inhibition by cytochalasans isolated from cultures of the ascomycete Hypoxylon fragiforme for the
Externí odkaz:
https://doaj.org/article/a65d3b900e954cc8930224b71ce2b5fe
Publikováno v:
Pharmaceuticals, Vol 3, Iss 5, Pp 1374-1393 (2010)
Many bacteria grow on surfaces forming biofilms. In this structure, they are well protected and often high dosages of antibiotics cannot clear infectious biofilms. The formation and stabilization of biofilms are mediated by diffusible autoinducers (e
Externí odkaz:
https://doaj.org/article/71e99575ba7641b5bbae56e2c541b241
Autor:
Kamila Tomoko Yuyama, Clara Chepkirui, Lucile Wendt, Diana Fortkamp, Marc Stadler, Wolf-Rainer Abraham
Publikováno v:
Microorganisms, Vol 5, Iss 4, p 80 (2017)
Treating infections organized in biofilms is a challenge due to the resistance of the pathogens against antibiotics and host immune cells. Many fungi grow in a wet environment, favorable for the growth of bacterial biofilms, and we speculated that fu
Externí odkaz:
https://doaj.org/article/f31e7c739bd34090ae06d39bff59b18d