Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Wolf-Dietrich Woggon"'
1
Modular Ligands for Dirhodium Complexes Facilitate Catalyst Customization
Autor: Dennis Gillingham, Antoinette Chougnet, Stefanie Geigle, Wolf-Dietrich Woggon, Daniel G. Bachmann, Pascal J. Schmidt
Publikováno v: Advanced Synthesis & Catalysis
Although stereoselectivity is often the focus of ligand optimizations in catalysis, ligand modularity can be used to control many other properties of catalysts. For example, solubility, amenability to purification, and steric shielding of sensitive c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a822d80c5df7bcdccccc8dd2d8528e6e
https://doi.org/10.1002/adsc.201500050
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2
Mechanistic study of proton transfer and hysteresis in catalytic antibody 16E7 by site-directed mutagenesis and homology modeling
Autor: Jean-Louis Reymond, Ulrich Baumann, Lei Zheng, Wolf Dietrich Woggon, Roman Manetsch
Publikováno v: Bioorganic & Medicinal Chemistry. 13:1021-1029
Antibody 16E7 catalyzes the carbon protonation of enol ether 2 to hemiacetal 3, and the carbon deprotonation of benzisoxazole 7 to phenol 8. This antibody shows an extreme case of hysteresis, requiring several hours to reach full activity. Antibody 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d26726559665d35b504d387ede5d98
https://doi.org/10.1016/j.bmc.2004.11.041
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3
A Catalytic Antibody against a Tocopherol Cyclase Inhibitor
Autor: Lei Zheng, Jean-Louis Reymond, Wolf Dietrich Woggon, Roman Manetsch, Martine T. Reymond
Publikováno v: Chemistry - A European Journal. 10:2487-2506
The cyclic ammonium cation 5 and its guanidinium analogue 4 are inhibitors of tocopherol cyclase. Monoclonal antibodies were raised against protein conjugates of the haptens 1-3 and screened for catalytic reactions with alkene 8, a short chain analog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68106246851a1cd6926beb830467ffe
https://doi.org/10.1002/chem.200305629
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5
Synthetic active site analogues of heme–thiolate proteins Characterization and identification of intermediates of the catalytic cycles of cytochrome P450cam and chloroperoxidase
Autor: Cécile Claude, Wolf-Dietrich Woggon, Hans-Achim Wagenknecht
Publikováno v: Journal of Inorganic Biochemistry. 83:289-300
In view of recent results from different sources, the reaction mechanisms of two heme–thiolate proteins, cytochrome P450 cam and chloroperoxidase (CPO), are discussed. In this context a mechanism of CPO is proposed which includes H 2 O 2 cleavage,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744d19218f0b52b00f3f79632fa703ad
https://doi.org/10.1016/s0162-0134(00)00175-6
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6
On the Origin of the Low-Spin Character of Cytochrome P450cam in the Resting State—Investigations of Enzyme Models with Pulse EPR and ENDOR Spectroscopy
Autor: Hamed Aissaoui, Arthur Schweiger, Rainer Bachmann, Wolf-Dietrich Woggon
Publikováno v: Angewandte Chemie International Edition. 37:2998-3002
The P450 enzyme model 1 is a high-spin system. EPR and ENDOR spectra reveal the coordination of water to the FeIII center. This is the first experimental proof that coordination of water is not the single determining factor in the stabilization of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::382b38b12e97eedca76506a5e9c98360
https://doi.org/10.1002/(sici)1521-3773(19981116)37:21<2998::aid-anie2998>3.0.co
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8
New Enzyme Models of Chloroperoxidase: Improved stability and catalytic efficiency of iron porphyrinates containing a thiolato ligand
Autor: Wolf-Dietrich Woggon, Hans-Achim Wagenknecht, Cécile Claude
Publikováno v: Helvetica Chimica Acta. 81:1506-1520
The heme-thiolate protein chloroperoxidase (CPO) catalyzes the chlorination of activated CH bonds. A reaction mechanism is proposed for this enzymatic transformation (Scheme 1), and a new iron(III) porphyrinate complex 13 is synthesized containing pe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b650ce7953ce8127dc71e45c230d26f
https://doi.org/10.1002/hlca.19980810554
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10
The synthesis of a new active-site analogue of cytochrome P450 carrying substrate recognition sites and athiolate ligand
Autor: Hamed Aissaoui, Christoph Gmür, Sandro Ghirlanda, Wolf-Dietrich Woggon
Publikováno v: Journal of Molecular Catalysis A: Chemical. 113:393-402
The synthesis of a new mono-bridged iron(III)porphyrin 2 is described which contains all structural elements significant to an active-site analogue of cytochrome P450: (i) a thiolate ligand coordinating to the iron, and (ii) a substrate-recognition s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee31f7f3f5f00742138cd2e0df6b2b19
https://doi.org/10.1016/s1381-1169(96)00166-5
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