Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Wolf-Dietrich Heyer"'
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appears to be re
Externí odkaz:
https://doaj.org/article/f7bfb44500064bbfab5f9926b917f7c1
Autor:
Eliana Moreira Tavares, William Douglass Wright, Wolf-Dietrich Heyer, Eric Le Cam, Pauline Dupaigne
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Homologous recombination uses a template to accurately repair DNA double-strand breaks and stalled replication forks to maintain genome stability. Here authors use electron microscopy to investigate the role of Rad54 in homology search and synaptic c
Externí odkaz:
https://doaj.org/article/6285e38938b646c09006dc0d1a12710a
Autor:
Hannah L Klein, Kenny K.H. Ang, Michelle R. Arkin, Emily C. Beckwitt, Yi-Hsuan Chang, Jun Fan, Youngho Kwon, Michael J. Morten, Sucheta Mukherjee, Oliver J. Pambos, Hafez el Sayyed, Elizabeth S. Thrall, João P. Vieira-da-Rocha, Quan Wang, Shuang Wang, Hsin-Yi Yeh, Julie S. Biteen, Peter Chi, Wolf-Dietrich Heyer, Achillefs N. Kapanidis, Joseph J. Loparo, Terence R. Strick, Patrick Sung, Bennett Van Houten, Hengyao Niu, Eli Rothenberg
Publikováno v:
Microbial Cell, Vol 6, Iss 1, Pp 65-101 (2019)
Genomes are constantly in flux, undergoing changes due to recombination, repair and mutagenesis. In vivo, many of such changes are studies using reporters for specific types of changes, or through cytological studies that detect changes at the single
Externí odkaz:
https://doaj.org/article/284d1fa54b1b42a89ebab92b52616ba5
Publikováno v:
eLife, Vol 9 (2020)
Displacement loops (D-loops) are signature intermediates formed during homologous recombination. Numerous factors regulate D-loop formation and disruption, thereby influencing crucial aspects of DNA repair, including donor choice and the possibility
Externí odkaz:
https://doaj.org/article/0b49950c133f4c2382f5323ebaf1c5a8
Autor:
Shanaya Shital Shah, Stella Hartono, Aurèle Piazza, Vanessa Som, William Wright, Frédéric Chédin, Wolf-Dietrich Heyer
Publikováno v:
eLife, Vol 9 (2020)
Displacement loops (D-loops) are critical intermediates formed during homologous recombination. Rdh54 (a.k.a. Tid1), a Rad54 paralog in Saccharomyces cerevisiae, is well-known for its role with Dmc1 recombinase during meiotic recombination. Yet contr
Externí odkaz:
https://doaj.org/article/b733ef15e04c47d69371f47d2ccc9a96
Autor:
Erin K Schwartz, Shih-Hsun Hung, Damon Meyer, Aurèle Piazza, Kevin Yan, Becky Xu Hua Fu, Wolf-Dietrich Heyer
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008816 (2020)
Alternative lengthening of telomeres (ALT) in human cells is a conserved process that is often activated in telomerase-deficient human cancers. This process exploits components of the recombination machinery to extend telomere ends, thus allowing for
Externí odkaz:
https://doaj.org/article/6f79717a621041d2b3c58938977ca6a5
Autor:
Jie Liu, Christopher Ede, William D Wright, Steven K Gore, Shirin S Jenkins, Bret D Freudenthal, M Todd Washington, Xavier Veaute, Wolf-Dietrich Heyer
Publikováno v:
eLife, Vol 6 (2017)
Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity. Gene
Externí odkaz:
https://doaj.org/article/05da620cad144c98b326782beef630fe
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 4, p e1003016 (2013)
Systematic analysis of synthetic lethality (SL) constitutes a critical tool for systems biology to decipher molecular pathways. The most accepted mechanistic explanation of SL is that the two genes function in parallel, mutually compensatory pathways
Externí odkaz:
https://doaj.org/article/28ded5d7f4994db49791f6666bf06a9f
Autor:
Xiao-Ping Zhang, Ryan Janke, James Kingsley, Jerry Luo, Clare Fasching, Kirk T Ehmsen, Wolf-Dietrich Heyer
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82184 (2013)
Rad54 is a dsDNA-dependent ATPase that translocates on duplex DNA. Its ATPase function is essential for homologous recombination, a pathway critical for meiotic chromosome segregation, repair of complex DNA damage, and recovery of stalled or broken r
Externí odkaz:
https://doaj.org/article/2e910d35ccaf4c22a6016b65cc989c39
