Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Wolf Wrasidlo"'
Autor:
Simona Eleuteri, Saviana Di Giovanni, Edward Rockenstein, Mike Mante, Antony Adame, Margarita Trejo, Wolf Wrasidlo, Fang Wu, Patrick C. Fraering, Eliezer Masliah, Hilal A. Lashuel
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 144-157 (2015)
Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, pathology spreading and toxicity. Therefore, targeti
Externí odkaz:
https://doaj.org/article/d4522a8f88c54dd9b37edc223ebe772e
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, Pp 742-747 (2010)
We have developed a synthetic route for the preparation of a hybrid bisubstrate small molecule based on a nucleoside. A prototype compound was designed and docked into the catalytic domain of the AdSS enzyme bridging the region between the magnesium
Externí odkaz:
https://doaj.org/article/88e9a4926466487fb449e8e667b2ad13
Autor:
Michiyo Iba, Changyoun Kim, Somin Kwon, Marcell Szabo, Liam Horan-Portelance, Cody J. Peer, William D. Figg, Xylena Reed, Jinhui Ding, Seung-Jae Lee, Robert A. Rissman, Mark R. Cookson, Cassia Overk, Wolf Wrasidlo, Eliezer Masliah
Publikováno v:
Science Translational Medicine. 15
Alterations in the p38 mitogen-activated protein kinases (MAPKs) play an important role in the pathogenesis of dementia with Lewy bodies (DLB) and Parkinson’s disease (PD). Activation of the p38α MAPK isoform and mislocalization of the p38γ MAPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::486afdc456c4b605000c06c28cacb40e
https://doi.org/10.1126/scitranslmed.abq6089
https://doi.org/10.1126/scitranslmed.abq6089
Autor:
Eliezer Masliah, Fang Wu, Margarita Trejo, Saviana Di Giovanni, Simona Eleuteri, Patrick C. Fraering, Wolf Wrasidlo, Edward Rockenstein, Antony Adame, Hilal A. Lashuel, Mike Mante
Publikováno v:
Neurobiology of Disease, Vol 74, Iss, Pp 144-157 (2015)
Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, pathology spreading and toxicity. Therefore, targeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b9250028f078a7a73a18839e7ad4ea
https://doi.org/10.1016/j.nbd.2014.08.017
https://doi.org/10.1016/j.nbd.2014.08.017
Autor:
Eliezer Masliah, Cassia R. Overk, Igor F. Tsigelny, Edward Rockenstein, Christina Patrick, Leslie Crews, Wolf Wrasidlo, Amy Paulino, Tania Gonzales, Diana L. Price, Valentina L. Kouznetsova, Emily Stocking
Publikováno v:
British Journal of Pharmacology. 171:5757-5773
Background and Purpose Anti-retrovirals have improved and extended the life expectancy of patients with HIV. However, as this population ages, the prevalence of cognitive changes is increasing. Aberrant activation of kinases, such as receptor tyrosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd11d6fb6f1a55e7eabee5db28ad4ee2
https://doi.org/10.1111/bph.12875
https://doi.org/10.1111/bph.12875
Autor:
Yongxuan Su, Stephen P. Adams, Eran Zahavy, Sadik C. Esener, Wolf Wrasidlo, John T. Norton, Tomoko Hayashi, Stuart Ibsen
Publikováno v:
Journal of Mass Spectrometry. 48:768-773
The localized conversion of inactive doxorubicin prodrug chemotherapeutics to pharmacalogically active forms is difficult to quantify in mouse tumor models because it occurs only in small regions of tissue. The tumor tissue extraction protocol and LC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12600282ad837821381cade0fc5c3eb6
https://doi.org/10.1002/jms.3221
https://doi.org/10.1002/jms.3221
Autor:
Alan L, Gillman, Joon, Lee, Srinivasan, Ramachandran, Ricardo, Capone, Tania, Gonzalez, Wolf, Wrasidlo, Eliezer, Masliah, Ratnesh, Lal
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 12(8)
Increased levels of soluble amyloid-beta (Aβ) oligomers are suspected to underlie Alzheimer's disease (AD) pathophysiology. These oligomers have been shown to form multi-subunit Aβ pores in bilayers and induce uncontrolled, neurotoxic, ion flux, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6af7784e0973b3612dbbdf9ef1d21b61
https://pubmed.ncbi.nlm.nih.gov/27335341
https://pubmed.ncbi.nlm.nih.gov/27335341
Publikováno v:
Bioconjugate Chemistry. 22:1638-1644
Quantum dots (QDs) are attracting intense interest as fluorescence labeling agents for biomedical imaging because biocompatible coatings and relatively non-toxic rare earth metal QDs have emerged as possible options. QD photoemissions are bright, of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c723193806a139b6a6d185591ce32c71
https://doi.org/10.1021/bc200201e
https://doi.org/10.1021/bc200201e
Autor:
Milan Makale, Wolf Wrasidlo, Robert M. Hoffman, Miriam Scadeng, Michael Bouvet, Ahmet Erten, Sadik C. Esener
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 6:797-807
We report here the in vivo combined-modality imaging of multifunctional drug delivery nanoparticles. These dextran core-based stealth liposomal nanoparticles (nanosomes) contained doxorubicin, iron oxide for magnetic resonance imaging (MRI) contrast,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f015dcb74214a8c7b61470d26219ae4
https://doi.org/10.1016/j.nano.2010.06.005
https://doi.org/10.1016/j.nano.2010.06.005
Autor:
Adrian Saldanha, Yanmei Zhang, Dennis A. Carson, Igor F. Tsigelny, Wolf Wrasidlo, Greg Elliot
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, Pp 742-747 (2010)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
We have developed a synthetic route for the preparation of a hybrid bisubstrate small molecule based on a nucleoside. A prototype compound was designed and docked into the catalytic domain of the AdSS enzyme bridging the region between the magnesium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426e9d780a4b088c8f1e05e2e9226b5e
https://doi.org/10.3762/bjoc.6.93
https://doi.org/10.3762/bjoc.6.93