Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Wolanin Donald John"'
Autor:
Diane Amy Trainor, Mark A. Zottola, Joseph C. Williams, Richard Alan Wildonger, Barbara Ewing, Wolanin Donald John, Russell C. Mauger, Chris A. Veale, Joseph James Lewis, Ann M. Strimpler, Donald W. Andisik, Tuthill Paul Anson, G. B. Steelman, Philip D. Edwards, Donna Rakiewicz, Bruce Gomes, Craig Bryant
Publikováno v:
Journal of Medicinal Chemistry. 40:1876-1885
Previously we had shown that tripeptidyl trifluoromethyl ketones (TFMKs) possessing an N-terminal diarylacylsulfonamide, such as ICI 200,880 and ICI 200,355, displayed unparalleled protection against the lung damage induced by human neutrophil elasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9693c01d8a433142f42ac0491b2b03d5
https://doi.org/10.1021/jm960819g
https://doi.org/10.1021/jm960819g
Publikováno v:
Journal of Medicinal Chemistry. 38:76-85
A series of peptidyl alpha-ketoheterocycles were synthesized and evaluated for their in vitro inhibition of human neutrophil elastase (HNE). Several heterocycles, including oxazoline and benzoxazole, afforded extremely potent inhibitors of HNE (1p-r)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55894d92864b03870748072cbec5bfdf
https://doi.org/10.1021/jm00001a013
https://doi.org/10.1021/jm00001a013
Autor:
Bruce Gomes, Scott W. Feeney, C. Ceccarelli, Joseph C. Williams, G. B. Steelman, Wolanin Donald John, Edward Vacek, Peter Warner, Andrew Shaw, Frederick J. Brown, Philip D. Edwards, B.J. Kosmider, Chris A. Veale, R. Green, Craig Bryant, James R. Damewood, Peter R. Bernstein, Tuthill Paul Anson, R. M. Thomas, S. Woolson, Donald W. Andisik
Publikováno v:
Pharmacochemistry Library ISBN: 9780444827982
Publisher Summary This chapter discusses computer-aided design of novel inhibitors of human leukocyte elastase (HLE). HLE is a member of the serine protease family of enzymes and is contained in the azurophilic granules of human neutrophils. It is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be781cc6cc7008bf92cf85cd16d3fa3c
https://doi.org/10.1016/s0165-7208(97)80090-6
https://doi.org/10.1016/s0165-7208(97)80090-6
Publikováno v:
Annual Reports in Medicinal Chemistry ISBN: 9780120405275
Publisher Summary Asthma has been characterized as a disease associated with chronic inflammation, which may underlie the prevalent bronchial hyperresponsiveness in asthmatics. Antagonism of intercellular adhesion molecule 1 (ICAM-1) is a novel thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc4dfe962b1410d0f5a44c8d872fc1ca
https://doi.org/10.1016/s0065-7743(08)60410-8
https://doi.org/10.1016/s0065-7743(08)60410-8
Autor:
Andrew Shaw, Steven P. Patton, Richard A. Roberts, Gene DiPasquale, Wolanin Donald John, Claudia B. Caputo, Linda A. Sygowski
Publikováno v:
Journal of Orthopaedic Research. 6:103-108
In vitro proteoglycan (PG) synthesis and release were measured on cartilage removed from rabbit knees within 1 week of meniscectomy. Three days following partial lateral meniscectomy, 72% of the femurs and 82% of the tibias had visible ulcers. Cartil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66b855734af260f071e0721f5c29dd2
https://doi.org/10.1002/jor.1100060113
https://doi.org/10.1002/jor.1100060113
Autor:
Gene DiPasquale, Wolanin Donald John, Richard A. Roberts, Robert G. Caccese, Steven P. Patton, Claudia B. Caputo, Andrew Shaw, Linda A. Sygowski
Publikováno v:
Biochemical Pharmacology. 36:995-1002
Synthetic inhibitors of a chondrocyte metalloprotease (CMP) were assessed for potency. Proteoglycan core protein was used as substrate. The ic 50 values were between 2 × 10 −6 and 7 × 10 −6 M for two types of inhibitors, thiol tripeptides and N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d727a932f4ca8f5e8662aa3c6da0290c
https://doi.org/10.1016/0006-2952(87)90405-9
https://doi.org/10.1016/0006-2952(87)90405-9
Autor:
R D Krell, Andrew Shaw, Wolanin Donald John, Stein Mark Morris, Roy M. Thomas, Peter R. Bernstein, Philip D. Edwards, James Hulsizer, Gary Moore, Chris A. Veale, Claudia M. Bohnert, Edward Vacek, Joseph C. Williams, Ben J. Kosmider, James R. Damewood, Frederick J. Brown, Scott W. Feeney, Craig Bryant, G. B. Steelman, Sheila Woolson, David S. Silberstein, Anne M. Strimpler, Theodora W. Salcedo, Bruce Gomes, Roger A. Earley
Publikováno v:
Scopus-Elsevier
This paper describes the development a series of peptidyl trifluoromethyl ketone inhibitors of human leukocyte elastase which are found to have excellent pharmacological profiles. Methods have been developed that allow for the synthesis of these inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96159885dcaea269d4720e36a3c1c02
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031726106&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031726106&partnerID=MN8TOARS