Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Wojciech Szczepek"'
1
Synthesis and Physicochemical Characterization of the Process-Related Impurities of Olmesartan Medoxomil. Do 5-(Biphenyl-2-yl)-1-triphenylmethyltetrazole Intermediates in Sartan Syntheses Exist?
Autor: Agata Białońska, Piotr Cmoch, Chmiel Justyna, Iwona Dams, Anna Ostaszewska, Maria Puchalska, Iwona Bujak, Wojciech Szczepek
Publikováno v: Molecules
Volume 20
Issue 12
Pages 21346-21363
Molecules, Vol 20, Iss 12, Pp 21346-21363 (2015)
Molecules; Volume 20; Issue 12; Pages: 21346-21363
During the process development for multigram-scale synthesis of olmesartan medoxomil (OM), two principal regioisomeric process-related impurities were observed along with the final active pharmaceutical ingredient (API). The impurities were identifie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2169cc547ac2a115db2cd93119b287f3
https://doi.org/10.3390/molecules201219762
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2
Searching for new derivatives of neocryptolepine: Synthesis, antiproliferative, antimicrobial and antifungal activities
Autor: Jessica A. Edward, Arkadiusz Kozubek, Anna Jaromin, Marta Świtalska, Joanna Zagrodzka, Joanna Stefańska, Łukasz Kaczmarek, Joanna Wietrzyk, Piotr Cmoch, Wanda Peczyńska-Czoch, David R. Andes, Robert Zarnowski, Katarzyna Sidoryk, Wojciech Szczepek
Publikováno v: European Journal of Medicinal Chemistry. 78:304-313
A series of novel amino acid and dipeptide derivatives of neocryptolepine were synthesized and tested for their antimicrobial, antifungal and antiproliferative activity in vitro against cancer cell lines (KB, A549, MCF-7, LoVo) and normal mice fibrob
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5222a75368ee79055006ebfe8d0f1198
https://doi.org/10.1016/j.ejmech.2014.03.060
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3
Indolo[2,3-b]quinoline derivatives as novel promising antitumor agents
Autor: Bogdan Zagrodzki, Lukasz Kaczmarek, Katarzyna Sidoryk, Wanda Peczyńska-Czoch, Wojciech Łuniewski, Katarzyna Badowska-Rosłonek, Wojciech Szczepek, Joanna Wietrzyk, Anna Jaromin
In the search for novel antineoplastic compounds we have found that four-membered, linear 5,11-dimethyl -5H- indolo[2,3-b]quinoline (DIMIQ) reveals cytostatic activity in vitro and moderate antitumor activity in vivo in mice melanoma B16 as well as l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47bbc31a4dc244dfd83f156bea8d93c5
https://doi.org/10.7287/peerj.preprints.1669v1
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4
Imatinib Inhibits the Renewal and Tumorigenicity of CT-26 Colon Cancer Cells after Cytoreductive Treatment with Doxorubicin
Autor: Paweł Swoboda, Łukasz Kaczmarek, Joanna Miłoszewska, Agnieszka Kotlarz, Wojciech Szczepek, Sergiusz Markowicz, Małgorzata Przybyszewska, Kazimiera Pyśniak
Publikováno v: Archivum immunologiae et therapiae experimentalis. 65(1)
Conventional anti-cancer drugs preferentially eliminate differentiated cancer cells but those cells that are spared (i.e. cancer stem cells: CSC), initiate recurrence. We tested whether drugs that target receptor tyrosine kinases (RTKs) involved in d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ad8d828633381564b9067393f57cea
https://pubmed.ncbi.nlm.nih.gov/26956644
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5
Flow injection amperometric detection of ammonia using a polypyrrole-modified electrode and its application in urea and creatinine biosensors
Autor: Wojciech Szczepek, Tadeusz Krawczyński vel Krawczyk, Marek Trojanowicz, Ilkka Lähdesmäki, Andrzej Lewenstam
Publikováno v: Electroanalysis. 8:233-243
The interaction of unprotonated ammonia molecules with polypyrrole (PPy) is employed for the amperometric detection of ammonia with the use of an anodically polarized platinum electrode modified with PPy as the working electrode. The polymer was obta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45a726a0c25a19a13df27f820eee054c
https://doi.org/10.1002/elan.1140080307
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6
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents
Autor: Marta Świtalska, Wanda Peczyńska-Czoch, Wojciech Szczepek, Joanna Wietrzyk, Piotr Cmoch, Katarzyna Sidoryk, Anna Jaromin, Łukasz Kaczmarek, Magdalena Piętka-Ottlik, Joanna Zagrodzka
Publikováno v: Journal of medicinal chemistry. 55(11)
The syntheses of neocryptolepine derivatives containing an amino acid or a dipeptide at the C-9 position and their evaluation for antitumor activity in vitro and in vivo are reported. To establish the influence of an amino acid or a peptide on the ph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af57337c553f8421358940d394e95398
https://pubmed.ncbi.nlm.nih.gov/22574992
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8
Synthesis of new n-substituted cyclic imides with expected anxiolytic activity. XXI. Derivatives of 1-acetyldibenzo-[e.h]-bicyclo[2.2.2]-octane-2,3-dicarboximide
Autor: Jerzy, Kossakowski, Wojciech, Szczepek, Magdalena, Pakosińska-Parys
Publikováno v: Acta poloniae pharmaceutica. 59(6)
The preparation of a number of new N-substituted derivatives of 1-acetyldibenzo-[e.h]-bicyclo[2.2.2]-octane-2,3-dicarboximide with an expected anxiolytic activity is described.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2db4d38fe691c53afe80376b53fb3c41
https://pubmed.ncbi.nlm.nih.gov/12669762
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