Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Wojciech Pietruś"'
Autor:
Delfina Popiel, Aleksandra Stańczak, Monika Skupińska, Agata Mikołajczyk, Paulina Stańczak, Filip Mituła, Joanna Hucz-Kalitowska, Kinga Jastrzębska, Damian Smuga, Jakub Dominowski, Monika Delis, Krzysztof Mulewski, Wojciech Pietruś, Daria Zdżalik-Bielecka, Karolina Dzwonek, Monika Lamparska-Przybysz, Abdellah Yamani, Patrycja Olejkowska, Natalia Piórkowska, Krzysztof Dubiel, Maciej Wieczorek, Jerzy Pieczykolan
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
Fibroblast Growth Factor Receptors (FGFRs) are a family of receptor tyrosine kinases expressed on a plethora of cell membranes. They play crucial roles in both embryonic development and adult tissue functions. There is an increasing amount of evidenc
Externí odkaz:
https://doaj.org/article/07e91621f37e47a8ab05a2c584ceb012
Autor:
Wojciech Pietruś, Mariola Stypik, Marcin Zagozda, Martyna Banach, Lidia Gurba-Bryśkiewicz, Wioleta Maruszak, Arkadiusz Leniak, Rafał Kurczab, Zbigniew Ochal, Krzysztof Dubiel, Maciej Wieczorek
Publikováno v:
Molecules, Vol 28, Iss 8, p 3531 (2023)
As a member of the class I PI3K family, phosphoinositide 3-kinase δ (PI3Kδ) is an important signaling biomolecule that controls immune cell differentiation, proliferation, migration, and survival. It also represents a potential and promising therap
Externí odkaz:
https://doaj.org/article/62c0899b09d24354ba8846e2be2ab71f
Autor:
Katarzyna Grychowska, Wojciech Pietruś, Ludmiła Kulawik, Ophélie Bento, Grzegorz Satała, Xavier Bantreil, Frédéric Lamaty, Andrzej J. Bojarski, Joanna Gołębiowska, Agnieszka Nikiforuk, Philippe Marin, Séverine Chaumont-Dubel, Rafał Kurczab, Paweł Zajdel
Publikováno v:
Molecules, Vol 28, Iss 3, p 1096 (2023)
Salt bridge (SB, double-charge-assisted hydrogen bonds) formation is one of the strongest molecular non-covalent interactions in biological systems, including ligand–receptor complexes. In the case of G-protein-coupled receptors, such an interactio
Externí odkaz:
https://doaj.org/article/813c1b8b56594a4e9a7cc04e5eb520b2
Publikováno v:
Molecules, Vol 28, Iss 2, p 490 (2023)
Currently, G protein-coupled receptors (GPCRs) constitute a significant group of membrane-bound receptors representing more than 30% of therapeutic targets. Fluorine is commonly used in designing highly active biological compounds, as evidenced by th
Externí odkaz:
https://doaj.org/article/559e0679c117414196be797e1f236ff9
Autor:
Mariola Stypik, Stanisław Michałek, Nina Orłowska, Marcin Zagozda, Maciej Dziachan, Martyna Banach, Paweł Turowski, Paweł Gunerka, Daria Zdżalik-Bielecka, Aleksandra Stańczak, Urszula Kędzierska, Krzysztof Mulewski, Damian Smuga, Wioleta Maruszak, Lidia Gurba-Bryśkiewicz, Arkadiusz Leniak, Wojciech Pietruś, Zbigniew Ochal, Mateusz Mach, Beata Zygmunt, Jerzy Pieczykolan, Krzysztof Dubiel, Maciej Wieczorek
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 927 (2022)
Phosphoinositide 3-kinase (PI3K) is the family of lipid kinases participating in vital cellular processes such as cell proliferation, growth, migration, or cytokines production. Due to the high expression of these proteins in many human cells and the
Externí odkaz:
https://doaj.org/article/a571ed7c657c4ae3a404d1e13d1d6daf
Publikováno v:
Molecules, Vol 27, Iss 3, p 1005 (2022)
Fluorine is a common substituent in medicinal chemistry and is found in up to 50% of the most profitable drugs. In this study, a statistical analysis of the nature, geometry, and frequency of hydrogen bonds (HBs) formed between the aromatic and aliph
Externí odkaz:
https://doaj.org/article/22010f55c5ec4f809b592f104bacb84b
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1647 (2021)
Currently, G protein-coupled receptors are the targets with the highest number of drugs in many therapeutic areas. Fluorination has become a common strategy in designing highly active biological compounds, as evidenced by the steadily increasing numb
Externí odkaz:
https://doaj.org/article/cd62e2b920104ecb91d770b5e194e417
Autor:
Philippe Marin, Miroslav Soural, Séverine Chaumont-Dubel, David Vanda, Elżbieta Pękala, Andrzej J. Bojarski, Martyna Krawczyk, Paweł Zajdel, Grzegorz Satała, Rafał Kurczab, Vittorio Canale, Piotr Popik, Wojciech Pietruś, Paulina Koczurkiewicz-Adamczyk, Klaudia Blicharz
Publikováno v:
Journal of Medicinal Chemistry. 64:1180-1196
G-protein coupled receptors (GPCRs) exist in an equilibrium of multiple conformational states, including different active states, which depend on the nature of the bound ligand. In consequence, different conformational states can initiate specific si
Autor:
Katarzyna Grychowska, Agnieszka Olejarz-Maciej, Klaudia Blicharz, Wojciech Pietruś, Tadeusz Karcz, Rafał Kurczab, Paulina Koczurkiewicz, Agata Doroz-Płonka, Gniewomir Latacz, Abdul Raheem Keeri, Kamil Piska, Grzegorz Satała, Joanna Pęgiel, Wojciech Trybała, Magdalena Jastrzębska-Więsek, Andrzej J. Bojarski, Frédéric Lamaty, Anna Partyka, Maria Walczak, Martyna Krawczyk, Natalia Malikowska-Racia, Piotr Popik, Paweł Zajdel
The incorporation of the fluorine motif is a strategy widely applied in drug design for modulating the activity, physicochemical parameters, and metabolic stability of chemical compounds. In this study, we attempted to reduce the affinity for ether-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f37b26f52cb6eaf288753ac901311bc
https://ruj.uj.edu.pl/xmlui/handle/item/293057
https://ruj.uj.edu.pl/xmlui/handle/item/293057
Publikováno v:
Molecules, Vol 27, Iss 1005, p 1005 (2022)
Molecules; Volume 27; Issue 3; Pages: 1005
Molecules; Volume 27; Issue 3; Pages: 1005
Fluorine is a common substituent in medicinal chemistry and is found in up to 50% of the most profitable drugs. In this study, a statistical analysis of the nature, geometry, and frequency of hydrogen bonds (HBs) formed between the aromatic and aliph