Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Wojciech Paslawski"'
Autor:
Ellen Appleton, Shervin Khosousi, Michael Ta, Michael Nalls, Andrew B. Singleton, Andrea Sturchio, Ioanna Markaki, Wojciech Paslawski, Hirotaka Iwaki, Per Svenningsson
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/2452f35a07f14ef3a8a8f025c9d8bf2d
Autor:
Wojciech Paslawski, Shervin Khosousi, Ellen Hertz, Ioanna Markaki, Adam Boxer, Per Svenningsson
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-14 (2023)
Abstract Background There is a need for biomarkers to support an accurate diagnosis of Parkinson’s disease (PD). Cerebrospinal fluid (CSF) has been a successful biofluid for finding neurodegenerative biomarkers, and modern highly sensitive multiple
Externí odkaz:
https://doaj.org/article/690fdcd95a324852b80ad553c25cf539
Autor:
Kaneyasu Nishimura, Shanzheng Yang, Ka Wai Lee, Emilía Sif Ásgrímsdóttir, Kasra Nikouei, Wojciech Paslawski, Sabine Gnodde, Guochang Lyu, Lijuan Hu, Carmen Saltó, Per Svenningsson, Jens Hjerling-Leffler, Sten Linnarsson, Ernest Arenas
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 337-353 (2023)
Summary: Stem cell technologies provide new opportunities for modeling cells in health and disease and for regenerative medicine. In both cases, developmental knowledge and defining the molecular properties and quality of the cell types is essential.
Externí odkaz:
https://doaj.org/article/fd31a42071de4262949542a104ae6e6c
Autor:
Rika Kojima, Wojciech Paslawski, Guochang Lyu, Ernest Arenas, Xiaoqun Zhang, Per Svenningsson
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 683 (2024)
Mutations in the GBA1 gene increase the risk of developing Parkinson’s disease (PD). However, most carriers of GBA1 mutations do not develop PD throughout their lives. The mechanisms of how GBA1 mutations contribute to PD pathogenesis remain unclea
Externí odkaz:
https://doaj.org/article/b8dd1357edf74481812500a79f186dcc
Autor:
Bright C. Uzuegbunam, Junhao Li, Wojciech Paslawski, Wolfgang Weber, Per Svenningsson, Hans Ågren, Behrooz Hooshyar Yousefi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16445 (2023)
The α-synucleinopathies are a group of neurodegenerative diseases characterized by the deposition of α-synuclein aggregates (α-syn) in the brain. Currently, there is no suitable tracer to enable a definitive early diagnosis of these diseases. We r
Externí odkaz:
https://doaj.org/article/5e01341d374c4b4fb963ee538f9f4c71
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract α-Synuclein (α-syn) is a key molecule linked to Parkinson’s disease pathology. Physiologically, the monomeric α-syn in the presynaptic termini is involved in regulation of neurotransmission, but the pathophysiology of extracellular mono
Externí odkaz:
https://doaj.org/article/4b97d65d7cf5443a8e76b0d1be8e1f55
Autor:
Bright C. Uzuegbunam, Junhao Li, Wojciech Paslawski, Wolfgang Weber, Per Svenningsson, Hans Ågren, Behrooz Hooshyar Yousefi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
The accumulation of α-synuclein aggregates (α-syn) in the human brain is an occurrence common to all α-synucleinopathies. Non-invasive detection of these aggregates in a living brain with a target-specific radiotracer is not yet possible. We have
Externí odkaz:
https://doaj.org/article/d3dac01057c643deb9c58d323b71ec0b
Autor:
Xavier Morató, Paula Garcia-Esparcia, Josep Argerich, Franc Llorens, Inga Zerr, Wojciech Paslawski, Eva Borràs, Eduard Sabidó, Ulla E. Petäjä-Repo, Víctor Fernández-Dueñas, Isidro Ferrer, Per Svenningsson, Francisco Ciruela
Publikováno v:
Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-14 (2021)
Abstract Objective α-Synuclein has been studied as a potential biomarker for Parkinson’s disease (PD) with no concluding results. Accordingly, there is an urgent need to find out reliable specific biomarkers for PD. GPR37 is an orphan G protein-co
Externí odkaz:
https://doaj.org/article/a6c99e3a8f2b442ca223489faa5b0b8f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14290 (2022)
GPR37L1 is an orphan G-protein-coupled receptor, which is implicated in neurological disorders, but its normal physiological role is poorly understood. Its close homologue, GPR37, is implicated in Parkinson’s disease and affective disorders. In thi
Externí odkaz:
https://doaj.org/article/660928661757479ab8446eb298d46a3a
Autor:
Mads N. Olesen, Josefine R. Christiansen, Steen Vang Petersen, Poul Henning Jensen, Wojciech Paslawski, Marina Romero-Ramos, Vanesa Sanchez-Guajardo
Publikováno v:
Heliyon, Vol 4, Iss 1 (2018)
We have previously shown that immunological processes in the brain during α-synuclein-induced neurodegeneration vary depending on the presence or absence of cell death. This suggests that the immune system is able to react differently to the differe
Externí odkaz:
https://doaj.org/article/5b9e58bc5a2a4fb0b029943aa0c6ee69