Challenges and Opportunities in IBD Clinical Trial Design

Autor: Marla C. Dubinsky, Rory Collins, Maria T. Abreu, Vipul Jairath, James D. Lewis, James Lindsay, Miriam Merad, Siew Ng, Remo Panaccione, Julian Panes, Bruce Sands, Corey A. Siegal, Siddarth Singh, Severine Vermeire, Vineet Ahuja, Matthieu Allez, Ashwin Ananthakrishnan, Willem Bemelman, Jonathan Braun, Jean-Frederic Colombel, Silvio Danese, Geert D’Haens, André D’Hoore, Axel Dignass, Iris Dotan, Miguel Angel Gassul, Anne Griffiths, Jonas Halfvarson, Stephen Hanauer, Paulo Kotze, Ioannis Koutroubakis, Edward Loftus, Edouard Louis, Fernando Magro, Gerassimos Mantzaris, Jean-Yves Mary, Dermot McGovern, Pia Munkholm, Colm O’Morain, Yves Panis, Laurent Peyrin-Biroulet, Cosimo Prantera, Zhihua Ran, Britta Siegmund, Mark Silverberg, Eduard Stange, Stephan Targan, Curt Tysk, Simon Travis, Morton Vatn, Yesus Yamamoto-Furusho, Janske Aarts, Brihad Abhyankar, Harris Ahmad, Richard Aranda, Vipin Arora, Jalil Benjacoub, Sofie Berg, Robin Besuyen, Daniela Bojic, Valerio Carriero, Fabio Cataldi, Laurence D’Agay, Silvia Delgado-Aros, Paul Giannasca, Kavitha Goyal, Roland Greinwald, Savion Gropper, Shunsuke Kageyama, Raphaël Laoun, Barrett Levesque, Trevor Lissoos, Irene Modesto, Ralf Mohrbacher, Ralph Mueller, April Naegeli, Snehal Naik, Deanne Nguyen, Wojciech Niezychowski, Caitriona O’Brien, Irina Odnoletkova, Alessandra Oortwijn, Kun K.T. Park, Waldemar Radziszewski, Leonardo Salese, Johannes Spleiss, Andrea Stancati, Amanda Tatro, Jennifer Thompson, Robert Hofmann, Javier Zambrano, Wen Zhou, Ellen Zigmont

Publikováno v: International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) 2021, ' Challenges and Opportunities in IBD Clinical Trial Design ', Gastroenterology, vol. 161, no. 2, pp. 400-404 . https://doi.org/10.1053/j.gastro.2021.03.065
Gastroenterology, 161(2), 400-404. W.B. Saunders Ltd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c272afd267a593087dd98af0c866112
https://curis.ku.dk/portal/da/publications/challenges-and-opportunities-in-ibd-clinical-trial-design(b6b0ec30-7f3c-4165-a128-1f4e70ec620b).html

Tofacitinib for induction and maintenance therapy of Crohn's disease: results of two phase IIb randomised placebo-controlled trials

Autor: Bruce E. Sands, Julián Panés, Gary Chan, Paul J. Healey, Stefan Schreiber, Michele Moscariello, Peter D.R. Higgins, Geert R. D'Haens, Amy Marren, Wojciech Niezychowski, Wenjin Wang, Brian G. Feagan, Severine Vermeire, E Maller, Jean-Frederic Colombel, William J. Sandborn, Remo Panaccione

Publikováno v: Gut
Gut, 66(6), 1049-1059. BMJ Publishing Group

Objective Tofacitinib is an oral, small-molecule Janus kinase inhibitor that is being investigated for IBD. We evaluated the efficacy and safety of tofacitinib for induction and maintenance treatment in patients with moderate-to-severe Crohn's diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0348ba2794e27e3084076a1404c868
https://doi.org/10.1136/gutjnl-2016-312735

Tofacitinib for Maintenance Therapy in Patients With Active Ulcerative Colitis in the Phase 3 OCTAVE Sustain Trial: Results by Local and Central Endoscopic Assessments

Autor: Deborah A Woodworth, Haiying Zhang, Julián Panés, Chinyu Su, Gary S. Friedman, Wojciech Niezychowski, Bruce E. Sands, Walter Reinisch, Brian G. Feagan, Severine Vermeire, Dino Tarabar, William J. Sandborn

Publikováno v: American Journal of Gastroenterology. 112:S329-S330

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b6603e1187343f5867c283587f4fab7
https://doi.org/10.14309/00000434-201710001-00607

OP031 Long-term safety and tolerability of oral tofacitinib in patients with Crohn's disease: results from a phase 2 open-label 48-week extension study

Autor: Chinyu Su, Julià Panés, Wojciech Niezychowski, Gary Chan, Peter D.R. Higgins, Linda Mele, Wenjin Wang, G. D'Haens, E Maller, Michele Moscariello

Publikováno v: Journal of Crohn's and Colitis. 11:S18-S19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::040c56d0665c0387620a2d762bb7788e
https://doi.org/10.1093/ecco-jcc/jjx002.030

OP032 Efficacy and safety of oral tofacitinib as maintenance therapy in patients with moderate to severe ulcerative colitis: results from a phase 3 randomised controlled trial

Autor: Severine Vermeire, Dahong Yu, Walter Reinisch, Chinyu Su, Julià Panés, Silvio Danese, Stefan Schreiber, G. D'Haens, Bruce E. Sands, Nervin Lawendy, W J Sandborn, Haiying Zhang, Deborah A Woodworth, Wojciech Niezychowski, Gary S. Friedman, Arnab Mukherjee, Paul J. Healey, Brian G. Feagan

Publikováno v: Journal of Crohn's and Colitis. 11:S19-S20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d730f614cc741313fbc002913f3036b3
https://doi.org/10.1093/ecco-jcc/jjx002.031