Výsledky vyhledávání - "Wojciech Niedzwiedz"

Akademický článek

Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2’s nuclease activity

Autor: Ronan Broderick, Veronica Cherdyntseva, Jadwiga Nieminuszczy, Eleni Dragona, Maria Kyriakaki, Theodora Evmorfopoulou, Sarantis Gagos, Wojciech Niedzwiedz

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Telomerase-independent cancer proliferation via the alternative lengthening of telomeres (ALT) relies upon two distinct, largely uncharacterized, break-induced-replication (BIR) processes. How cancer cells initiate and regulate these termina

Externí odkaz: https://doaj.org/article/4c85c2750cba42c18c6c9d363e697013

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Akademický článek

Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress

Autor: Jérémy Sandoz, Max Cigrang, Amélie Zachayus, Philippe Catez, Lise-Marie Donnio, Clèmence Elly, Jadwiga Nieminuszczy, Pietro Berico, Cathy Braun, Sergey Alekseev, Jean-Marc Egly, Wojciech Niedzwiedz, Giuseppina Giglia-Mari, Emmanuel Compe, Frédéric Coin

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Here the authors show that the exonuclease EXD2 is involved in the recovery of class II gene transcription after UV irradiation. EXD2 travels from the mitochondria to the nucleus to interact with RNA Pol II and degrade new synthetized mRNA to allow t

Externí odkaz: https://doaj.org/article/a0d3f932123e4cc6bc846c308c77597d

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Akademický článek

WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage

Autor: Seong-Su Han, Kuo-Kuang Wen, María L. García-Rubio, Marc S. Wold, Andrés Aguilera, Wojciech Niedzwiedz, Yatin M. Vyas

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Cancer develops in Wiskott-Aldrich syndrome (WAS). Here the authors identify a role for WAS-protein (WASp) in the DNA stress-resolution pathway by promoting the function of Replication Protein A at replication forks after DNA damage.

Externí odkaz: https://doaj.org/article/6e499727fe454b339e1196dece4c37d7

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Akademický článek

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

Autor: Xianning Lai, Ronan Broderick, Valérie Bergoglio, Jutta Zimmer, Sophie Badie, Wojciech Niedzwiedz, Jean-Sébastien Hoffmann, Madalena Tarsounas

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

BRCA2-deficient cells fail to complete replication in S-phase, which results in DNA bridges and chromosome mis-segregation at mitosis. Here the authors show that MUS81 helps BRCA2-deficient cells survive replication stress by activating mitotic DNA s

Externí odkaz: https://doaj.org/article/a8a9dca4e29c43adad08bdc9e4343805

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Akademický článek

Correction: Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

Autor: Xianning Lai, Ronan Broderick, Valérie Bergoglio, Jutta Zimmer, Sophie Badie, Wojciech Niedzwiedz, Jean-Sébastien Hoffmann, Madalena Tarsounas

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-3 (2017)

Nature Communications 8: Article number: 15983 (2017); Published: 17 July 2017; Updated: 26 October 2017 In this Article, there are errors in the labelling of the y axis in Fig. 1a and Supplementary Fig. 1b. The labels ‘20’, ‘40’, ‘60’, �

Externí odkaz: https://doaj.org/article/34574dfb75be41acbdd43dc3fd63e567

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Akademický článek

BRCA2 Coordinates the Activities of Cell-Cycle Kinases to Promote Genome Stability

Autor: Keiko Yata, Jean-Yves Bleuyard, Ryuichiro Nakato, Christine Ralf, Yuki Katou, Rebekka A. Schwab, Wojciech Niedzwiedz, Katsuhiko Shirahige, Fumiko Esashi

Publikováno v: Cell Reports, Vol 7, Iss 5, Pp 1547-1559 (2014)

Numerous human genome instability syndromes, including cancer, are closely associated with events arising from malfunction of the essential recombinase Rad51. However, little is known about how Rad51 is dynamically regulated in human cells. Here, we

Externí odkaz: https://doaj.org/article/b74b4e6518364c7ea181813928cbc69e

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