Neuro- and Cardiovascular Activities of Montivipera bornmuelleri Snake Venom

Autor: Christina Sahyoun, Wojciech Krezel, César Mattei, Jean-Marc Sabatier, Christian Legros, Ziad Fajloun, Mohamad Rima

Publikováno v: Biology, Vol 11, Iss 6, p 888 (2022)

The complications following snake bite envenoming are due to the venom’s biological activities, which can act on different systems of the prey. These activities arise from the fact that snake venoms are rich in bioactive molecules, which are also o

Externí odkaz: https://doaj.org/article/6648a183f7074e01bba5a62113ee3059

Increased Viral Dissemination in the Brain and Lethality in MCMV-Infected, Dicer-Deficient Neonates

Autor: Eleonore Ostermann, Cécile Macquin, Wojciech Krezel, Seiamak Bahram, Philippe Georgel

Publikováno v: Viruses, Vol 7, Iss 5, Pp 2308-2320 (2015)

Among Herpesviruses, Human Cytomegalovirus (HCMV or HHV-5) represents a major threat during congenital or neonatal infections, which may lead to encephalitis with serious neurological consequences. However, as opposed to other less prevalent pathogen

Externí odkaz: https://doaj.org/article/4ceed23eb5ba48f88616b9d3dff848c8

Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement

Autor: Samridhi Sharma, Ting Shen, Nitin Chitranshi, Veer Gupta, Devaraj Basavarajappa, Soumalya Sarkar, Mehdi Mirzaei, Yuyi You, Wojciech Krezel, Stuart L. Graham, Vivek Gupta

Publikováno v: Molecular Neurobiology. 59:2027-2050

Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain. The receptor exists in α, β, and γ isotypes that form homo-/heterodimeric complexes with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b3b04c535ead29611a20a2095995f2
https://doi.org/10.1007/s12035-021-02709-y

Intronic elements associated with insomnia and restless legs syndrome exhibit cell type-specific epigenetic features contributing to MEIS1 regulation

Autor: Nazanin Mirza-Schreiber, Wojciech Krezel, Juliane Winkelmann, Ana Antic Nikolic, Konrad Oexle, Daniel D. Lam, Chen Zhao

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, 2021, 31 (11), pp.1733-1746. ⟨10.1093/hmg/ddab355⟩
Hum. Mol. Genet. 31, 1733-1746 (2021)

A highly evolutionarily conserved MEIS1 intronic region is strongly associated with restless legs syndrome (RLS) and insomnia. To understand its regulatory function, we dissected the region by analyzing chromatin accessibility, enhancer-promoter cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d7646e4ae4eb4351a6197459cf1677
https://doi.org/10.1101/2021.09.03.458823

Vitamin A5/X, a New Food to Lipid Hormone Concept for a Nutritional Ligand to Control RXR-Mediated Signaling

Autor: Rosana Alvarez, Aurea Rivas, Monika Szklenar, Wojciech Krezel, Angel R. de Lera, Ralph Rühl, Marion Ciancia

Publikováno v: Nutrients
Investigo. Repositorio Institucional de la Universidade de Vigo
Universidade de Vigo (UVigo)
Nutrients; Volume 13; Issue 3; Pages: 925
Nutrients, 2021, 13 (3), pp.925. ⟨10.3390/nu13030925⟩
Nutrients, Vol 13, Iss 925, p 925 (2021)

Background: Vitamin A is a family of derivatives synthesized from carotenoids acquired from the diet and can be converted in animals to bioactive forms essential for life. The vitamin A1 (all-trans-retinol / ATROL) and provitamin A1 (all-trans-β,β-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06814bc3ee386ea044b205127f37c92a
https://pubmed.ncbi.nlm.nih.gov/33809241