Výsledky vyhledávání - "Wojciech K Mydlarz"

Akademický článek

Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors.

Autor: Megan L Durr, Wojciech K Mydlarz, Chunbo Shao, Marianna L Zahurak, Alice Y Chuang, Mohammad O Hoque, William H Westra, Nanette J Liegeois, Joseph A Califano, David Sidransky, Patrick K Ha

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10828 (2010)

Methylation profiling of tumor suppressor gene (TSGs) promoters is quickly becoming a powerful diagnostic tool for the early detection, prognosis, and even prediction of clinical response to treatment. Few studies address this in salivary gland tumor

Externí odkaz: https://doaj.org/article/ac6e9c54c38641f4aa5ff3b9f06610a6

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Akademický článek

Cure of syngeneic carcinomas with targeted IL-12 through obligate reprogramming of lymphoid and myeloid immunity

Autor: Youji Hong, Yvette Robbins, Xinping Yang, Wojciech K. Mydlarz, Anastasia Sowers, James B. Mitchell, James L. Gulley, Jeffrey Schlom, Sofia R. Gameiro, Cem Sievers, Clint T. Allen

Publikováno v: JCI Insight, Vol 7, Iss 5 (2022)

Therapeutic IL-12 has demonstrated the ability to reduce local immune suppression in preclinical models, but clinical development has been limited by severe inflammation-related adverse events with systemic administration. Here, we show that potent i

Externí odkaz: https://doaj.org/article/087a78f2b3ee4f39ba65e786fa395d71

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Data from Neoadjuvant PD-1 Immune Checkpoint Blockade Reverses Functional Immunodominance among Tumor Antigen–Specific T Cells

Autor: Clint Allen, Ravindra Uppaluri, Carter Van Waes, Hans Schreiber, James W. Hodge, Nicole Schmitt, Wojciech K. Mydlarz, Megan V. Morisada, Sarah Greene, Lilian Sun, Paul E. Clavijo, Yvette Robbins, Paul Zolkind, Ellen C. Moore, Jay Friedman

Purpose:Surgical resection of primary tumor with regional lymphadenectomy remains the treatment of choice for patients with advanced human papillomavirus–negative head and neck squamous cell carcinoma. However, even when pathologic disease-free mar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de81563eb2f456c738cee6f8856993c
https://doi.org/10.1158/1078-0432.c.6529710.v1

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Supplementary Figure S7 from Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

Autor: Clint Allen, Paul E. Clavijo, John A. Zebala, Dean Y. Maeda, Jeffrey Schlom, Claudia Palena, Lucas A. Horn, Jay Friedman, Nicole C. Schmitt, Angel P. Huynh, Wojciech K. Mydlarz, Yvette Robbins, Sarah Greene

Supplemental Figure S7. SX-682 treatment does not alter PMN-MDSC suppressive capacity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d32e1729179b2c8191a3483bb36eac6
https://doi.org/10.1158/1078-0432.22478684

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Supplementary Data from Neoadjuvant PD-1 Immune Checkpoint Blockade Reverses Functional Immunodominance among Tumor Antigen–Specific T Cells

Supplemental data not critical for the main conclusions of the work but important for critical review of the data.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8edadb7c9d403686753efd5bac3db1
https://doi.org/10.1158/1078-0432.22477623

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Data from Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

Purpose:Natural killer (NK)-cell–based immunotherapy may overcome obstacles to effective T-cell–based immunotherapy such as the presence of genomic alterations in IFN response genes and antigen presentation machinery. All immunotherapy approaches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c83b154859a3605e7859ad97fb58723
https://doi.org/10.1158/1078-0432.c.6530021.v1

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Supplementary Methods from Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

Methods not essential to the main conclusions but important for critical review of methods used for this work

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5ecc3ab0347cbce114b16bbcc7a4de
https://doi.org/10.1158/1078-0432.22478678.v1

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Management of Multiple Head and Neck Paragangliomas With Assistance of a 3-D Model

Autor: Jing Zhou, Lifeng Li, Zhenya Yu, Hongbo Xu, Nyall R. London, Xiaohong Chen, Wojciech K. Mydlarz

Publikováno v: Ear, Nose & Throat Journal. 102:362-368

Introduction: Extirpation of multiple head and neck paragangliomas carries challenge due to close anatomic relationships with critical neurovascular bundles. Objectives: This study aims to assess whether the application of 3-D models can assist with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a88906dcfe1c28bf5b230d46d6804ba
https://doi.org/10.1177/01455613211009441

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