Glutamate, Glutamine and GABA Levels in Rat Brain Measured Using MRS, HPLC and NMR Methods in Study of Two Models of Autism

Autor: Elzbieta Zieminska, Beata Toczylowska, Dominik Diamandakis, Wojciech Hilgier, Robert Kuba Filipkowski, Rafal Polowy, Jaroslaw Orzel, Michal Gorka, Jerzy Wieslaw Lazarewicz

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

The disorders of the glutamatergic neurotransmission have been associated with pathogenesis of autism. In this study we evaluated the impact of the in vivo and ex vivo test methodology on measurements of levels of neurotransmitter amino acids in hipp

Externí odkaz: https://doaj.org/article/9dd87ae23c9c46c996192db4b588174b

Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase

Autor: Coral Barbas, Anita Chęcińska, Małgorzata Beręsewicz-Haller, Olga Krupska, Danuta Dudzik, Krzysztof Zabłocki, Barbara Zabłocka, Wojciech Hilgier, Paweł Bochomulski

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 8504, p 8504 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 16; Pages: 8504
International Journal of Molecular Sciences

Ischemic episodes are a leading cause of death worldwide with limited therapeutic interventions. The current study explored mitochondrial phosphate-activated glutaminase (GLS1) activity modulation by PKCβII through GC-MS untargeted metabolomics appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd01b8761ff62c3fb2c76bb2d422ff42
https://www.mdpi.com/1422-0067/22/16/8504

Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson’s Disease Etiopathology

Autor: Magdalena Gąssowska-Dobrowolska, Anna Wilkaniec, Wojciech Hilgier, Henryk Jęśko, Grzegorz A. Czapski, Anna M. Lenkiewicz, Robert Brodzik, Agata Adamczyk, Carsten Culmsee

Publikováno v: Molecular Neurobiology

α-Synuclein (ASN) and parkin, a multifunctional E3 ubiquitin ligase, are two proteins that are associated with the pathophysiology of Parkinson’s disease (PD). Excessive release of ASN, its oligomerization, aggregation, and deposition in the cytop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc38b7f67c6d5caecdb3eaaec0680670
http://europepmc.org/articles/PMC6334739

Cerebrovascular reactivity and cerebral perfusion of rats with acute liver failure: role of L-glutamine and asymmetric dimethylarginine in L-arginine-induced response

Autor: Radosław Jaźwiec, Magdalena Zielińska, Krzysztof Jasiński, Wojciech Hilgier, Anna M. Czarnecka, Marta Aleksandrowicz, Katarzyna Kalita

Publikováno v: Journal of neurochemistry. 147(5)

Cerebral blood flow (CBF) is impaired in acute liver failure (ALF), however, the complexity of the underlying mechanisms has often led to inconclusive interpretations. Regulation of CBF depends at least partially on variations in the local brain L-ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95d6c1e0a8cdbdf69bcad2bfd95235a
https://pubmed.ncbi.nlm.nih.gov/30151828

Altered Expression of Urea Cycle Enzymes in Amyloid-β Protein Precursor Overexpressing PC12 Cells and in Sporadic Alzheimer's Disease Brain

Autor: Anna Wilkaniec, Agata Adamczyk, Wojciech Hilgier, Walter J. Lukiw, Emilia Murawska, Magdalena Gąssowska-Dobrowolska, Henryk Jęśko, Magdalena Cieślik

Publikováno v: Journal of Alzheimer's disease : JAD. 62(1)

Urea cycle enzymes may play important yet poorly characterized roles in Alzheimer's disease (AD). Our previous results showed that amyloid-β (Aβ) affects urea cycle enzymes in rat pheochromocytoma (PC12) cells. The aim of the present study was to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c70310eb639f5452a734d288eb873c
https://pubmed.ncbi.nlm.nih.gov/29439324