Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Wojciech G Garbacz"'
Autor:
Ye Feng, Dan Xu, Xinran Cai, Meishu Xu, Wojciech G Garbacz, Songrong Ren, Michael J Jurczak, Chaohui Yu, Hui Wang, Wen Xie
Publikováno v:
Endocrinology. 163(7)
Diabetes and related metabolic syndrome are common metabolic disorders. Gestational diabetes mellitus (GDM) is rather prevalent in the clinic. Although most GDM resolves after therapeutic intervention and/or after delivery, the long-term health effec
Publikováno v:
PPAR Research, Vol 2015 (2015)
Peroxisome proliferator activated receptors alpha (PPARα) and delta (PPARδ) belong to the nuclear receptor superfamily. PPARα is a target of well established lipid-lowering drugs. PPARδ (also known as PPARβ/δ) has been investigated as a promisi
Externí odkaz:
https://doaj.org/article/0dfe6640f4594d10afa023cd9f19ee12
Autor:
Larry G. Higgins, Wojciech G. Garbacz, Mattias C. U. Gustafsson, Sitheswaran Nainamalai, Peter R. Ashby, C. Roland Wolf, Colin N. A. Palmer
Publikováno v:
PPAR Research, Vol 2012 (2012)
The nuclear receptor, NR1C2 or peroxisome proliferator-activated receptor (PPAR)-δ, is ubiquitously expressed and important for placental development, fatty acid metabolism, wound healing, inflammation, and tumour development. PPARδ has been hypoth
Externí odkaz:
https://doaj.org/article/15b3b22a60b4410cabade62c119dcb71
Chronic Activation of Liver X Receptor Sensitizes Mice to High Cholesterol Diet–Induced Gut Toxicity
Autor:
Meishu Xu, Min Huang, Donna B Stolz, Wojciech G. Garbacz, Songrong Ren, Jiong Yan, Hirdesh Uppal, Wen Xie
Publikováno v:
Molecular Pharmacology. 94:1145-1154
Cholesterol is essential for numerous biologic functions and processes, but an excess of intracellular cholesterol can be toxic. Intestinal cholesterol absorption is a major determinant of plasma cholesterol level. The liver X receptor (LXR) is a nuc
Publikováno v:
Endocrinology. 158:4093-4104
Estrogen sulfotransferase catalyzes the sulfoconjugation and deactivation of estrogens. Previously, we showed that loss of Est in male ob/ob mice, but not in female ob/ob mice, exacerbated the diabetic phenotype, but the underlying mechanism was uncl
Autor:
Wojciech G. Garbacz, Graham Mayrhofer, Nicholas S. Eyre, Tricia M. Miller, Meishu Xu, Songrong Ren, Peipei Lu, Samuel M. Poloyac, Wen Xie
Publikováno v:
Molecular and Cellular Biology. 36:2715-2727
The common complications in obesity and type 2 diabetes include hepatic steatosis and disruption of glucose-glycogen homeostasis, leading to hyperglycemia. Fatty acid translocase (FAT/CD36), whose expression is inducible in obesity, is known for its
Autor:
Yuhan Bi, Wojciech G. Garbacz, Sihan Li, Peipei Lu, Yongdong Niu, Satdarshan P.S. Monga, Jinhan He, Yanping Li, Wen Xie, Songrong Ren, Robert F. Schwabe, Hung-Chun Tung, Jiong Yan, Meishu Xu, Da Yang
Publikováno v:
Gastroenterology
Background & Aims The role of aryl hydrocarbon receptor (AhR) in liver fibrosis is controversial because loss and gain of AhR activity both lead to liver fibrosis. The goal of this study was to investigate how the expression of AhR by different liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0606691a61ffb6d3a44bfa1aa2d34d8
https://europepmc.org/articles/PMC6707837/
https://europepmc.org/articles/PMC6707837/
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1852(9):1912-1927
The estrogen-related receptors (ERRs) comprise a small group of orphan nuclear receptor transcription factors. The ERRα and ERRγ isoforms play a central role in the regulation of metabolic genes and cellular energy metabolism. Although less is know
Autor:
Xiongjie Shi, Yixian Huang, Wen Xie, Li Gao, Songrong Ren, Jiong Yan, Wojciech G. Garbacz, Xiudong Guan, Song Li, Yuhan Bi, Yulan Liu, Xiaochao Ma, Meishu Xu, Junjie Zhu, Shunlin Ren
Publikováno v:
Molecular and cellular biology. 38(7)
The cholesterol sulfotransferase SULT2B1b converts cholesterol to cholesterol sulfate (CS). We previously reported that SULT2B1b inhibits hepatic gluconeogenesis by antagonizing the gluconeogenic activity of hepatocyte nuclear factor 4α (HNF4α). In
Publikováno v:
Advances in experimental medicine and biology. 1043
Sulfonation and desulfation are two opposing processes that represent an important layer of regulation of estrogenic activity via ligand supplies. Enzymatic activities of families of enzymes, known as sulfotransferases and sulfatases, lead to structu