Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Wojciech Bocian"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17445 (2023)
The new 5-substituted SN-38 derivatives, 5(R)-(N-pyrrolidinyl)methyl-7-ethyl-10-hydroxycamptothecin (1) and its diastereomer 5(S) (2), were investigated using a combination of nuclear magnetic resonance (NMR) spectroscopy and molecular modeling metho
Externí odkaz:
https://doaj.org/article/1466c4815bbe47248939d95c556d00d1
Autor:
Wojciech Bocian, Beata Naumczuk, Magdalena Urbanowicz, Jerzy Sitkowski, Elżbieta Bednarek, Katarzyna Wiktorska, Anna Pogorzelska, Ewelina Wielgus, Lech Kozerski
Publikováno v:
Molecules, Vol 27, Iss 20, p 6946 (2022)
The understanding of the mechanism of Topo I inhibition by organic ligands is a crucial source of information that has led to the design of more effective and safe pharmaceuticals in oncological chemotherapy. The vast number of inhibitors that have b
Externí odkaz:
https://doaj.org/article/723e9304008a456483bf9f48a82cbe21
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 7139 (2021)
Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid. The mechanism of interaction of
Externí odkaz:
https://doaj.org/article/cf700fb071694f35858cf50c46a1d507
Autor:
Wojciech Bocian, Beata Naumczuk, Magdalena Urbanowicz, Jerzy Sitkowski, Anna Bierczyńska-Krzysik, Elżbieta Bednarek, Katarzyna Wiktorska, Małgorzata Milczarek, Lech Kozerski
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7471 (2021)
The compounds 7-ethyl-9-(N-methylamino)methyl-10-hydroxycamptothecin (2) and 7-ethyl-9-(N-morpholino)methyl-10-hydroxycamptothecin (3) are potential topoisomerase I poisons. Moreover, they were shown to have favorable anti-neoplastic effects on sever
Externí odkaz:
https://doaj.org/article/333cfa843c6943e8844782d6f38eeb5b
Autor:
Elżbieta Bednarek, Wojciech Bocian, Magdalena Urbanowicz, Jerzy Sitkowski, Beata Naumczuk, Lech Kozerski
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8190 (2021)
Novel nontoxic derivatives of SN38 with favorable antineoplastic properties were characterized in water solution using NMR. The phenomena observed by NMR were linked to basic pharmacological properties, such as solubility, bioavailability, chemical a
Externí odkaz:
https://doaj.org/article/6d46a4007a8544ba9c8efa1b9ba71131
Autor:
Olga Staszewska-Krajewska, Wojciech Bocian, Magdalena Maciejko, Piotr Szcześniak, Krzysztof Szymczak, Marek Chmielewski, Bartłomiej Furman
Publikováno v:
ARKIVOC, Vol 2014, Iss 3, Pp 143-153 (2014)
Externí odkaz:
https://doaj.org/article/d0340c19a5fd48f7b72f04976b15170b
Publikováno v:
Magnetic Resonance in Chemistry. 58:191-197
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7139, p 7139 (2021)
Volume 22
Issue 13
International Journal of Molecular Sciences, Vol 22, Iss 7139, p 7139 (2021)
Volume 22
Issue 13
Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid. The mechanism of interaction of
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 169:170-180
NMR spectroscopy is used to investigate the host-guest complexation of (R)-tedizolid, such as tedizolid with the hydroxymethyl substituent at the C5 position of the oxazolidinone ring ((R)-TED) or tedizolid with 5-methyl dihydrogen phosphate ((R)-TED
Autor:
Lech Kozerski, Robert Kawęcki, Elżbieta Bednarek, Jerzy Sitkowski, Wojciech Bocian, Beata Naumczuk
Publikováno v:
Journal of Molecular Structure. 1176:298-302
We present first evidence of a spontaneous alkylation of the 2′-deoxycytidine by potential topoisomerase I inhibitors from camptothecins family. The 7-ethyl-9-(N-morpholino)methyl-10-hydroxycamptothecin and the 7-ethyl-9-(N-pyrrolidinyl)methyl-10-h