Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Wojciech Ardelt"'
Publikováno v:
Scopus-Elsevier
Onconase (Onc), a ribonuclease from oocytes of Northern Leopard frogs (Rana pipienss) is cytostatic and cytotoxic to a variety of tumor lines in vitro, inhibits growth of tumors in animal in vivo models and enhances sensitivity of tumor cells to a nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdfe0eb551e099f67ae6604f24288b1
https://doi.org/10.4161/cc.7.20.6855
https://doi.org/10.4161/cc.7.20.6855
Autor:
Wojciech Ardelt, Cindy Schulenburg, Zbigniew Darzynkiewicz, Ulrich Arnold, Barbara Ardelt, Renate Ulbrich-Hofmann, Kuslima Shogen
Publikováno v:
Scopus-Elsevier
Onconase (ONC) is a cytotoxic ribonuclease of the pancreatic ribonuclease A super-family isolated from oocytes or early embryos of the Northern leopard frog ( Rana pipiens ). It shows anticancer activity and currently is in Phase IIIb clinical trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78a7800aa8fcdf2c401ca848c39b0a8
https://doi.org/10.4161/cbt.6.8.4423
https://doi.org/10.4161/cbt.6.8.4423
Publikováno v:
Laboratory Medicine. 34:380-387
Early work by Shogen and Yoon1 demonstrated an anti-tumor activity in extracts of Northern leopard frog (Rana pipiens) embryos. More than a decade later, in 1987, the main active component of those extracts was isolated and purified by Alfacell M. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a494628659dfa9d96ff39908335020e3
https://doi.org/10.1309/3td26gxn65gec1bg
https://doi.org/10.1309/3td26gxn65gec1bg
Publikováno v:
Laboratory Medicine. 34:380-387
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ce1c63a70868d1941401b454b8d12ad
https://doi.org/10.1309/3td2-6gxn-65ge-c1bg
https://doi.org/10.1309/3td2-6gxn-65ge-c1bg
Autor:
William J. Kohr, Tadeusz Wilusz, James R. Cook, Michael Ranjbar, Jacek Otlewski, Sabiha Qasim, Nicholas Warne, Theresa L. Bigler, Anna Wieczorek, Wenlei Zhang, Tiao-Yin Lin, Michael Laskowski, Izydor Apostol, Harry Whatley, Richard Wynn, Tomoko Komiyama, Stephen M. Lu, Misao Tashiro, Maciej Wieczorek, Michio Ogawa, Soon Jae Park, Wojciech Ardelt, Wuyuan Lu, M. A. Qasim, Stephen Anderson, I. Kato, Clyde A. Kelly, Yi Wen Chiang, Michael N.G. James
Publikováno v:
Proceedings of the National Academy of Sciences. 98:1410-1415
An additivity-based sequence to reactivity algorithm for the interaction of members of the Kazal family of protein inhibitors with six selected serine proteinases is described. Ten consensus variable contact positions in the inhibitor were identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da2f63f2dc3c13d0d9ed6a9130ee32c
https://doi.org/10.1073/pnas.98.4.1410
https://doi.org/10.1073/pnas.98.4.1410
Autor:
Xun Li, Zbigniew Darzynkiewicz, Barbara Ardelt, K Shogen, Wojciech Ardelt, SM Mikulski, Gloria Juan, Abraham Mittelman
Publikováno v:
Scopus-Elsevier
Onconase is a 12 kDa protein homologous to pancreatic RNase A isolated from amphibian oocytes which shows cytostatic and cytotoxic activity in vitro, inhibits growth of tumors in mice and is in phase III clinical trials. The present study was aimed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b44d34c9f2ebfd50deb005bba7c353e
https://doi.org/10.1038/sj.leu.2401100
https://doi.org/10.1038/sj.leu.2401100
Autor:
Sally E. Spence, Susanna M. Rybak, Stanislaw M. Mikulski, William E. Fogler, John W. Pearson, Dianne L. Newton, Kirk Volker, Charles W. Riggs, Wojciech Ardelt, Dan L. Longo, Hsiang-Fu Kung
Publikováno v:
JNCI: Journal of the National Cancer Institute. 88:747-753
Background : Onconase, a protein isolated from oocytes and early embryos of the frog Rana pipiens, shares extensive homology with bovine pancreatic ribonuclease (RNase A) and possesses similar enzyme activity. Onconase is cytotoxic toward cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a1e359e516dcf2eb5e86dd663ea59f
https://doi.org/10.1093/jnci/88.11.747
https://doi.org/10.1093/jnci/88.11.747
Autor:
Wojciech Ardelt, Steven C. Mosimann, Kuslima Shogen, Kathy Johns, Stanislaw M. Mikulski, Michael N.G. James
Publikováno v:
Proteins: Structure, Function, and Genetics. 14:392-400
The P-30 protein (Onconase) of Rana pipiens oocytes and early embryos is homologous to members of the pancreatic ribonuclease superfamily and exhibits an antitumor activity in vitro and in vivo. It appears that the ribonucleolytic activity of P-30 pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b499fce2da641e6f416f7135187f149f
https://doi.org/10.1002/prot.340140308
https://doi.org/10.1002/prot.340140308
Publikováno v:
European journal of pharmacology. 625(1-3)
Antitumor ribonucleases are small (10-28 kDa) basic proteins. They were found among members of both, ribonuclease A and T1 superfamilies. Their cytotoxic properties are conferred by enzymatic activity, i.e., the ability to catalyze cleavages of phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b977d7664c29fa679e8db5a0b55c2f3
https://pubmed.ncbi.nlm.nih.gov/19825371
https://pubmed.ncbi.nlm.nih.gov/19825371