Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Wohn-Jenn Leu"'
Autor:
Hao-Cheng Weng, Chieh-Ju Sung, Jui-Ling Hsu, Wohn-Jenn Leu, Jih-Hwa Guh, Fan-Lu Kung, Lih-Ching Hsu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Breast cancer is the most prevalent cancer and the second leading cause of cancer death in women. Cisplatin is a commonly used chemotherapeutic drug for breast cancer treatment. Owing to serious side effects, the combination of cisplatin with other d
Externí odkaz:
https://doaj.org/article/87867dc881c5485886ec66bb7c2bddb4
Autor:
Tzu-En Huang, Yi-Ning Deng, Jui-Ling Hsu, Wohn-Jenn Leu, Elena Marchesi, Massimo L. Capobianco, Paolo Marchetti, Maria Luisa Navacchia, Jih-Hwa Guh, Daniela Perrone, Lih-Ching Hsu
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy in adults and accounts for 85–90% of all primary liver cancer. Based on the estimation by the International Agency for Research on Cancer in 2018, liver cancer is the fourth
Externí odkaz:
https://doaj.org/article/311890ab56b4453cad17527f699ccc44
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Combination therapies that display cancer-killing activities through either coexistent targeting of several cellular factors or more efficient suppression of a specific pathway are generally used in cancer treatment. Sildenafil, a specific phosphodie
Externí odkaz:
https://doaj.org/article/dd23ac1a86c643c987fc66a50d488968
Publikováno v:
Molecules, Vol 26, Iss 19, p 5967 (2021)
Non-small cell lung cancer (NSCLC), an aggressive subtype of pulmonary carcinomas with high mortality, accounts for 85% of all lung cancers. Drug resistance and high recurrence rates impede the chemotherapeutic effect, making it urgent to develop new
Externí odkaz:
https://doaj.org/article/0770d624bb1d4ed394ad37c29e9bf129
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11239 (2021)
Acute myeloid leukemia (AML) is one of the most common forms of leukemia. Despite advances in the management of such malignancies and the progress of novel therapies, unmet medical needs still exist in AML because of several factors, including poor r
Externí odkaz:
https://doaj.org/article/4d86401008fa472d9d96c68440780ae4
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Uncontrolled inflammation may produce massive inflammatory cytokines, in which interleukin 1β (IL-1β) plays a key role, resulting in tissue damage and serious disorders. The activation of NLRP3 inflammasome is one of the major mechanisms in maturat
Externí odkaz:
https://doaj.org/article/d90bc7a23b4941478672787f6de26885
Autor:
Jo-Fan Chang, Jui-Ling Hsu, Yi-Hua Sheng, Wohn-Jenn Leu, Chia-Chun Yu, She-Hung Chan, Mei-Ling Chan, Lih-Ching Hsu, Shih-Ping Liu, Jih-Hwa Guh
Publikováno v:
Frontiers in Oncology, Vol 8 (2019)
Human castration-resistant prostate cancer (CRPC) is a significant target of clinical research. The use of DNA-damaging agents has a long history in cancer chemotherapy but is limited by their toxicities. The combination with a safer drug can be a st
Externí odkaz:
https://doaj.org/article/3a701bd102534e719249fe95c6948b24
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Castration-resistant prostate cancer (CRPC) cells can resist many cellular stresses to ensure survival. There is an unmet medical need to fight against the multiple adaptive mechanisms in cells to achieve optimal treatment in patients. Para-toluenesu
Externí odkaz:
https://doaj.org/article/b8822ca5ee1a4e4eaea64528320dfbe8
Autor:
Wohn-Jenn Leu, Jung-Chun Chu, Jui-Ling Hsu, Chi-Min Du, Yi-Huei Jiang, Lih-Ching Hsu, Wei-Jan Huang, Jih-Hwa Guh
Publikováno v:
Molecules, Vol 25, Iss 24, p 5960 (2020)
Chalcones are responsible for biological activity throughout fruits, vegetables, and medicinal plants in preventing and treating a variety of inflammation-related diseases. However, their structure-activity relationship (SAR) in inhibiting inflammaso
Externí odkaz:
https://doaj.org/article/6c068a267a3649be80837d5cfc800d68
Autor:
Ya-Ching Chang, Yu-Ling Tseng, Wohn-Jenn Leu, Chi-Min Du, Yi-Huei Jiang, Lih-Ching Hsu, Jui-Ling Hsu, Duen-Ren Hou, Jih-Hwa Guh
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5608 (2020)
Non-small cell lung cancer (NSCLC) accounts about 80% of all lung cancers. More than two-thirds of NSCLC patients have inoperable, locally advanced or metastatic tumors. Non-toxic agents that synergistically potentiate cancer-killing activities of ch
Externí odkaz:
https://doaj.org/article/8df6adcf8de84eceaea471eb1847ce9e