Loss of p14 diminishes immunogenicity in melanoma via non-canonical Wnt signaling by reducing the peptide surface density.

Autor: Wohlfarth J; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany., Kosnopfel C; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany., Faber D; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany., Berthold M; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany., Siedel C; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany., Bernhardt M; Rudolf-Virchow-Centre for Integrative and Translational Bioimaging, University of Würzburg, Germany., Schlosser A; Rudolf-Virchow-Centre for Integrative and Translational Bioimaging, University of Würzburg, Germany., Aprati T; Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Liu D; Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Schrama D; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany., Houben R; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany., Schadendorf D; Department of Dermatology, Comprehensive Cancer Center (Westdeutsches Tumorzentrum), German Cancer Consortium (DKTK, partner site Essen) and University Hospital Essen, Germany., Goebeler M; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany., Meierjohann S; Institute of Pathology, University of Würzburg, Germany., Schilling B; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany.

Publikováno v: Molecular oncology [Mol Oncol] 2024 Oct; Vol. 18 (10), pp. 2449-2470. Date of Electronic Publication: 2024 May 28.

Susceptibility of Melanoma Cells to Targeted Therapy Correlates with Protection by Blood Neutrophils.

Autor: Wendlinger S; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany.; Mildred Scheel Early Career Center Wuerzburg, University Hospital Wuerzburg, 97080 Würzburg, Germany., Wohlfarth J; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany., Siedel C; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany., Kreft S; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany.; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX, UK., Kilian T; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany., Junker S; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany., Schmid L; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany., Sinnberg T; Division of Dermatooncology, Department of Dermatology, University of Tübingen, 72076 Tübingen, Germany.; Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Dischinger U; Department of Endocrinology and Diabetology, University Hospital Würzburg, 97080 Würzburg, Germany., Heppt MV; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Wistuba-Hamprecht K; Skin Cancer Unit, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, 68167 Mannheim, Germany., Meier F; Department of Dermatology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.; Skin Cancer Center at the University Cancer Centre Dresden and National Center for Tumor Diseases, 01307 Dresden, Germany., Erpenbeck L; Department of Dermatology, University of Münster, 48149 Münster, Germany., Neubert E; Leiden Academic Centre for Drug Research, Leiden University, 2333 Leiden, The Netherlands.; Department of Dermatology, Venereology and Allergology, University Medical Center, Göttingen University, 37075 Göttingen, Germany., Goebeler M; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany., Gesierich A; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany., Schrama D; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany., Kosnopfel C; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany.; Mildred Scheel Early Career Center Wuerzburg, University Hospital Wuerzburg, 97080 Würzburg, Germany.; Department of Hematology, Oncology and Pneumology, University Hospital Münster, 48149 Münster, Germany., Schilling B; Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany.

Publikováno v: Cancers [Cancers (Basel)] 2024 May 02; Vol. 16 (9). Date of Electronic Publication: 2024 May 02.

Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion.

Autor: Kosnopfel C; Department of Hematology, Oncology and Pneumology, University Hospital Muenster, 48149, Muenster, Germany. corinnaveronica.kosnopfel@ukmuenster.de.; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080, Wuerzburg, Germany. corinnaveronica.kosnopfel@ukmuenster.de.; Mildred Scheel Early Career Center Wuerzburg, University Hospital Wuerzburg, 97080, Wuerzburg, Germany. corinnaveronica.kosnopfel@ukmuenster.de., Wendlinger S; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080, Wuerzburg, Germany.; Mildred Scheel Early Career Center Wuerzburg, University Hospital Wuerzburg, 97080, Wuerzburg, Germany., Niessner H; Division of Dermatooncology, Department of Dermatology, University of Tuebingen, 72076, Tuebingen, Germany., Siewert J; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080, Wuerzburg, Germany., Sinnberg T; Division of Dermatooncology, Department of Dermatology, University of Tuebingen, 72076, Tuebingen, Germany.; Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany., Hofmann A; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080, Wuerzburg, Germany., Wohlfarth J; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080, Wuerzburg, Germany., Schrama D; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080, Wuerzburg, Germany., Berthold M; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080, Wuerzburg, Germany., Siedel C; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080, Wuerzburg, Germany., Sauer B; Division of Dermatooncology, Department of Dermatology, University of Tuebingen, 72076, Tuebingen, Germany., Jayanthan A; Phoenix Molecular Designs, Vancouver, BC, Canada., Lenz G; Department of Hematology, Oncology and Pneumology, University Hospital Muenster, 48149, Muenster, Germany., Dunn SE; Phoenix Molecular Designs, Vancouver, BC, Canada., Schilling B; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080, Wuerzburg, Germany., Schittek B; Division of Dermatooncology, Department of Dermatology, University of Tuebingen, 72076, Tuebingen, Germany.

Publikováno v: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Jul 19; Vol. 42 (1), pp. 175. Date of Electronic Publication: 2023 Jul 19.

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269 Human immuno-competent 3D model of Malignant Melanoma: preclinical efficacy assessment of checkpoint inhibitors

Autor: Wussmann, M., Wohlfarth, J., Schilling, B., Groeber-Becker, F.

Publikováno v: In Journal of Investigative Dermatology October 2021 141(10) Supplement:S194-S194