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Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells

Autor: Zhang, Yu Wei, Mess, Julian, Aizarani, Nadim, Mishra, Pankaj, Johnson, Carys, Romero-Mulero, Mari Carmen, Rettkowski, Jasmin, Schönberger, Katharina, Obier, Nadine, Jäcklein, Karin, Woessner, Nadine M, Lalioti, Maria-Eleni, Velasco-Hernandez, Talia, Sikora, Katarzyna, Wäsch, Ralph, Lehnertz, Bernhard, Sauvageau, Guy, Manke, Thomas, Menendez, Pablo, Walter, Sebastian Gottfried, Minguet, Susana, Laurenti, Elisa, Günther, Stefan, Grün, Dominic, Cabezas-Wallscheid, Nina

Publikováno v: Nature Cell Biology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Funder: Wellcome Trust
Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied by dormant HSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0207886a42a2fa2ece9ce839f70a39
https://www.repository.cam.ac.uk/handle/1810/339386

Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling.

Autor: Rückert, Tamina, Andrieux, Geoffroy, Boerries, Melanie, Hanke-Müller, Kathrin, Woessner, Nadine M., Doetsch, Stephanie, Schell, Christoph, Aumann, Konrad, Kolter, Julia, Schmitt-Graeff, Annette, Schiff, Marcel, Braun, Lukas M., Haring, Eileen, Kissel, Sandra, Siranosian, Benjamin A., Bhatt, Ami S., Nordkild, Peter, Wehkamp, Jan, Jensen, Benjamin A. H., Minguet, Susana

Publikováno v: Science Translational Medicine; 12/21/2022, Vol. 14 Issue 676, p1-16, 16p

Additional file 2 of Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions

Autor: Kästle, Matthias, Merten, Camilla, Hartig, Roland, Kaehne, Thilo, Ardiyanto Liaunardy-Jopeace, Woessner, Nadine M., Schamel, Wolfgang W., James, John, Minguet, Susana, Simeoni, Luca, Schraven, Burkhart

Additional file 1: Figure S1. Normal T-cell development and T-cell activation in LckY192F knock-in mice. (A) Thymocytes from Lckwt and LckY192F knock-in mice were stained with CD4 and CD8 antibodies. Representative dot plots from 3 independent experi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612c1c147c84ad25a18260211b4f8457

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