Comparison of tet(X4)-containing contigs assembled from metagenomic sequencing data with plasmid sequences of isolates from a cohort of healthy subjects

Autor: Yichen Ding, Shuan Er, Abel Tan, Jean-Sebastien Gounot, Woei-Yuh Saw, Linda Wei Lin Tan, Yik Ying Teo, Niranjan Nagarajan, Henning Seedorf

Publikováno v: Microbiology Spectrum, Vol 12, Iss 4 (2024)

ABSTRACTRecently discovered tet(X) gene variants have provided new insights into microbial antibiotic resistance mechanisms and their potential consequences for public health. This study focused on detection, analysis, and characterization of Tet(X4)

Externí odkaz: https://doaj.org/article/3e4538feafde426bb738823c70014ced

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Autor: Fumihiko Takeuchi, Masato Akiyama, Nana Matoba, Tomohiro Katsuya, Masahiro Nakatochi, Yasuharu Tabara, Akira Narita, Woei-Yuh Saw, Sanghoon Moon, Cassandra N. Spracklen, Jin-Fang Chai, Young-Jin Kim, Liang Zhang, Chaolong Wang, Huaixing Li, Honglan Li, Jer-Yuarn Wu, Rajkumar Dorajoo, Jovia L. Nierenberg, Ya Xing Wang, Jing He, Derrick A. Bennett, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Hiromi Rakugi, Eitaro Nakashima, Masato Isono, Matsuyuki Shirota, Atsushi Hozawa, Sahoko Ichihara, Tatsuaki Matsubara, Ken Yamamoto, Katsuhiko Kohara, Michiya Igase, Sohee Han, Penny Gordon-Larsen, Wei Huang, Nanette R. Lee, Linda S. Adair, Mi Yeong Hwang, Juyoung Lee, Miao Li Chee, Charumathi Sabanayagam, Wanting Zhao, Jianjun Liu, Dermot F. Reilly, Liang Sun, Shaofeng Huo, Todd L. Edwards, Jirong Long, Li-Ching Chang, Chien-Hsiun Chen, Jian-Min Yuan, Woon-Puay Koh, Yechiel Friedlander, Tanika N. Kelly, Wen Bin Wei, Liang Xu, Hui Cai, Yong-Bing Xiang, Kuang Lin, Robert Clarke, Robin G. Walters, Iona Y. Millwood, Liming Li, John C. Chambers, Jaspal S. Kooner, Paul Elliott, Pim van der Harst, The International Genomics of Blood Pressure (iGEN-BP) Consortium, Zhengming Chen, Makoto Sasaki, Xiao-Ou Shu, Jost B. Jonas, Jiang He, Chew-Kiat Heng, Yuan-Tsong Chen, Wei Zheng, Xu Lin, Yik-Ying Teo, E-Shyong Tai, Ching-Yu Cheng, Tien Yin Wong, Xueling Sim, Karen L. Mohlke, Masayuki Yamamoto, Bong-Jo Kim, Tetsuro Miki, Toru Nabika, Mitsuhiro Yokota, Yoichiro Kamatani, Michiaki Kubo, Norihiro Kato

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and repor

Externí odkaz: https://doaj.org/article/7c763ccbcec74bc6b4f1c9dd802eadad

Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study

Autor: Woei-Yuh Saw, Erwin Tantoso, Husna Begum, Lihan Zhou, Ruiyang Zou, Cheng He, Sze Ling Chan, Linda Wei-Lin Tan, Lai-Ping Wong, Wenting Xu, Don Kyin Nwe Moong, Yenly Lim, Bowen Li, Nisha Esakimuthu Pillai, Trevor A. Peterson, Tomasz Bielawny, Peter J. Meikle, Piyushkumar A. Mundra, Wei-Yen Lim, Ma Luo, Kee-Seng Chia, Rick Twee-Hee Ong, Liam R. Brunham, Chiea-Chuen Khor, Heng Phon Too, Richie Soong, Markus R. Wenk, Peter Little, Yik-Ying Teo

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

The Singapore Genome Variation projects characterized the genetics of Singapore’s Chinese, Malay, and Indian populations. The Singapore Integrative Omics Study introduced here goes further in providing multi-omic measurements in individuals from th

Externí odkaz: https://doaj.org/article/f9ba61bb1a8a4f8bb334f97c504bd7ea

Phylogeography of Y-chromosome haplogroup O3a2b2-N6 reveals patrilineal traces of Austronesian populations on the eastern coastal regions of Asia.

Autor: Lan-Hai Wei, Shi Yan, Yik-Ying Teo, Yun-Zhi Huang, Ling-Xiang Wang, Ge Yu, Woei-Yuh Saw, Rick Twee-Hee Ong, Yan Lu, Chao Zhang, Shu-Hua Xu, Li Jin, Hui Li

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175080 (2017)

Austronesian diffusion is considered one of the greatest dispersals in human history; it led to the peopling of an extremely vast region, ranging from Madagascar in the Indian Ocean to Easter Island in Remote Oceania. The Y-chromosome haplogroup O3a2

Externí odkaz: https://doaj.org/article/b33df6de14fa4eb98339f90cfac76397

Evaluating the coverage and potential of imputing the exome microarray with next-generation imputation using the 1000 Genomes Project.

Autor: Erwin Tantoso, Lai-Ping Wong, Bowen Li, Woei-Yuh Saw, Wenting Xu, Peter Little, Rick Twee-Hee Ong, Yik-Ying Teo

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e106681 (2014)

Next-generation genotyping microarrays have been designed with insights from large-scale sequencing of exomes and whole genomes. The exome genotyping arrays promise to query the functional regions of the human genome at a fraction of the sequencing c

Externí odkaz: https://doaj.org/article/fd301340715c4046ad64156a1645d267