Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Woei C. Lam"'
Autor:
Charles A. Specht, Ruiying Wang, Lorena V. N. Oliveira, Maureen M. Hester, Christina Gomez, Zhongming Mou, Diana Carlson, Chrono K. Lee, Camaron R. Hole, Woei C. Lam, Rajendra Upadhya, Jennifer K. Lodge, Stuart M. Levitz
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT The global burden of infections due to the pathogenic fungus Cryptococcus is substantial in persons with low CD4+ T-cell counts. Previously, we deleted three chitin deacetylase genes from Cryptococcus neoformans to create a chitosan-deficien
Externí odkaz:
https://doaj.org/article/06a1bf7a6e2243f584d221896bb3e019
Publikováno v:
Frontiers in Fungal Biology, Vol 4 (2023)
IntroductionCryptococcus neoformans is a basidiomycete fungus that can cause meningoencephalitis, especially in immunocompromised patients. Cryptococcus grows in many different media, although little attention has been paid to the role of growth cond
Externí odkaz:
https://doaj.org/article/b9f329651c3f42faad0f3ad02a3787e0
Autor:
Rajendra Upadhya, Woei C. Lam, Camaron R. Hole, Danealle Parchment, Chrono K. Lee, Charles A. Specht, Stuart M. Levitz, Jennifer K. Lodge
Publikováno v:
The Cell Surface, Vol 7, Iss , Pp 100066- (2021)
Chitosan, a deacetylated form of chitin, is required for the virulence of Cryptococcus neoformans. There are three chitin deacetylase genes (CDA) that are essential for chitosan production, and deletion of all three genes results in the absence of ch
Externí odkaz:
https://doaj.org/article/6e8b69ee789c4441b354836b1b93ffaf
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Cryptococcus neoformans infections are significant causes of morbidity and mortality among AIDS patients and the third most common invasive fungal infection in organ transplant recipients. One of the main interfaces between the fungus and th
Externí odkaz:
https://doaj.org/article/b8b69574390d42e7869ca5cc72624bfa
Autor:
Brian T. Maybruck, Woei C. Lam, Charles A. Specht, Ma. Xenia G. Ilagan, Maureen J. Donlin, Jennifer K. Lodge
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Cryptococcus neoformans can cause fatal meningoencephalitis in patients with AIDS or other immunocompromising conditions. Current antifungals are suboptimal to treat this disease; therefore, novel targets and new therapies are needed. Previo
Externí odkaz:
https://doaj.org/article/b3cde10d9e614e4c8f1c4ec327805652
Autor:
Woei C. Lam, Rajendra Upadhya, Charles A. Specht, Abigail E. Ragsdale, Camaron R. Hole, Stuart M. Levitz, Jennifer K. Lodge
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
ABSTRACT Cryptococcus gattii R265 is a hypervirulent fungal strain responsible for the recent outbreak of cryptococcosis in Vancouver Island of British Columbia in Canada. It differs significantly from Cryptococcus neoformans in its natural environme
Externí odkaz:
https://doaj.org/article/a3f9a04f2eba4ac6b1976aa0d535e3d5
Autor:
Rajendra Upadhya, Lorina G. Baker, Woei C. Lam, Charles A. Specht, Maureen J. Donlin, Jennifer K. Lodge
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Chitin is an essential component of the cell wall of Cryptococcus neoformans conferring structural rigidity and integrity under diverse environmental conditions. Chitin deacetylase genes encode the enyzmes (chitin deacetylases [Cdas]) that d
Externí odkaz:
https://doaj.org/article/d6e613ec492c4b0b8e3f5e22fe269e90
Autor:
Rajendra Upadhya, Woei C. Lam, Brian Maybruck, Charles A. Specht, Stuart M. Levitz, Jennifer K. Lodge
Publikováno v:
mBio, Vol 7, Iss 3 (2016)
ABSTRACT Cryptococcus neoformans is a major opportunistic fungal pathogen that causes fatal meningoencephalitis in immunocompromised individuals and is responsible for a large proportion of AIDS-related deaths. The fungal cell wall is an essential or
Externí odkaz:
https://doaj.org/article/44f603daa0f74948b563711e14233614
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
mBio
mBio, Vol 11, Iss 1, p e03373-19 (2020)
mBio
mBio, Vol 11, Iss 1, p e03373-19 (2020)
Cryptococcus neoformans is the most common disseminated fungal pathogen in AIDS patients, resulting in ∼200,000 deaths each year. There is a pressing need for new treatments for this infection, as current antifungal therapy is hampered by toxicity
Autor:
Maureen J. Donlin, Jennifer K. Lodge, Ma. Xenia G. Ilagan, Charles A. Specht, Woei C. Lam, Brian T. Maybruck
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
mBio
mBio, Vol 10, Iss 6, p e02264-19 (2019)
mBio
mBio, Vol 10, Iss 6, p e02264-19 (2019)
Cryptococcus neoformans is a fungal pathogen that kills ∼200,000 people every year. The cell wall is an essential organelle that protects fungi from the environment. Chitosan, the deacetylated form of chitin, has been shown to be an essential compo