Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Wobbler disease"'
Autor:
Amanda R. Taylor, Sharon C. Kerwin
Publikováno v:
The Veterinary clinics of North America. Small animal practice. 51(2)
Although lameness of the thoracic limb typically is due to orthopedic disease, there are several important neurologic conditions that result in lameness. Neurologic diseases cause lameness due to disease of the nerves, nerve roots, spinal cord, or mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98944782f4bb70b0bfa9db3304602f2c
https://pubmed.ncbi.nlm.nih.gov/33558012
https://pubmed.ncbi.nlm.nih.gov/33558012
Akademický článek
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Autor:
Laura Garay, Maria Meyer, Gisella Gargiulo Monachelli, Alejandro F. De Nicola, Analia Lima, Paulina Roig, Maria Claudia Gonzalez Deniselle, Rachida Guennoun, Michael Schumacher
Publikováno v:
Cellular and Molecular Neurobiology. 30:123-135
In the Wobbler mouse, a mutation in the Vps54 gene is accompanied by motoneuron degeneration and astrogliosis in the cervical spinal cord. Previous work has shown that these abnormalities are greatly attenuated by progesterone treatment of clinically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf9be10e9e148827693a4f68059f611
https://doi.org/10.1007/s10571-009-9437-8
https://doi.org/10.1007/s10571-009-9437-8
Publikováno v:
Experimental Neurology. 198:114-128
The wobbler mouse is one of the most useful models of motoneuron degeneration, characterized by selective motoneuronal death in the cervical spinal cord. We carried out two parallel studies in wobbler mice, comparing the anti-glutamatergic drug riluz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e59dddb7b6546659bcfb0d4d6697d6
https://doi.org/10.1016/j.expneurol.2005.11.010
https://doi.org/10.1016/j.expneurol.2005.11.010
Autor:
Noel Fitzpatrick, James M. Fingeroth
Publikováno v:
Advances in Intervertebral Disc Disease in Dogs and Cats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0333e026f602b75bb0102dee84079da2
https://doi.org/10.1002/9781118940372.ch7
https://doi.org/10.1002/9781118940372.ch7
Publikováno v:
Experimental Neurology. 162:311-320
The purpose of this study was to characterize the alterations in muscle contractile (tension-pCa relationship) and biochemical (myosin heavy and light chains, troponin C content) properties in a hereditary motoneuron disease. The study was performed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c568ab4b316be30b922863652f399c
https://doi.org/10.1006/exnr.1999.7349
https://doi.org/10.1006/exnr.1999.7349
Publikováno v:
Journal of Neuroscience Research. 59:100-106
During late postnatal development, mice with the autosomal recessive wobbler mutation (wr/wr) develop motoneuron degeneration associated with astrogliosis in the spinal cord. In vitro, primary wobbler astrocytes are also affected, exhibiting abnormal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::991d1bf2bb17cad158d37325df3007b5
https://doi.org/10.1002/(sici)1097-4547(20000101)59:1<100::aid-jnr12>3.0.co
https://doi.org/10.1002/(sici)1097-4547(20000101)59:1<100::aid-jnr12>3.0.co
Publikováno v:
Developmental Dynamics. 209:286-295
Human hereditary neurodegenerative diseases are genetically and mechanistically very heterogeneous and so are spinal muscular atrophies and cerebellar ataxias in the mouse, despite the common phenomenon of neuronal death. In this species, a number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f43442eec613f336e347f5b0b4a34d
https://doi.org/10.1002/(sici)1097-0177(199707)209:3<286::aid-aja4>3.0.co
https://doi.org/10.1002/(sici)1097-0177(199707)209:3<286::aid-aja4>3.0.co
Publikováno v:
New Zealand Veterinary Journal. 42:221-228
The aim of this study was to investigate the prevalence of wobbler disease within a Dobermann pinscher population from three geographical locations in New Zealand. The study population consisted of 138 adults (aged 1-13 years) and 32 puppies (aged 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebf1f6032efe258dec22279fbd6773b
https://doi.org/10.1080/00480169.1994.35827
https://doi.org/10.1080/00480169.1994.35827
Publikováno v:
Muscle & Nerve. 16:542-547
To investigate axonal function in a model of early motor neuron disease, we examined fast and slow components of anterograde axonal transport in the less-affected hindlimb motor neurons of wobbler mice. To study the fast component (FC), we injected t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3887e5980b0b85bc75d935f1155ca9be
https://doi.org/10.1002/mus.880160517
https://doi.org/10.1002/mus.880160517