Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Wnt inhibitor"'
Reversing MET‐Mediated Resistance in Oncogene‐Driven NSCLC by MET‐Activated Wnt Condensative Prodrug
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract The amplification of MET is a major cause of acquired resistance to targeted therapy in EGFR‐mutant non‐small‐cell lung cancer (NSCLC), only to be temporarily restrained by the partial efficacy of MET inhibitors. This study reveals tha
Externí odkaz:
https://doaj.org/article/4cacd5327ecb4c1ca460e65eb265bd71
Autor:
A. S. Goncharova, A. V. Galina, D. V. Khodakova, G. Yu. Egorov, A. Yu. Maksimov, E. N. Kolesnikov, E. F. Komarova, A. A. Kiblitskaya, E. V. Zaikina, L. Z. Kurbanova, M. V. Mindar
Publikováno v:
Issledovaniâ i Praktika v Medicine, Vol 9, Iss 1, Pp 33-42 (2022)
Purpose of the study. Was to analyze antitumor efficacy of the XAV 939 Wnt signaling pathway inhibitor and its combination with 5 fluorouracil in subcutaneous xenografts derived from patients with colorectal cancer.Materials and methods. Antitumor ef
Externí odkaz:
https://doaj.org/article/47e3e1fb01e848bf8cf5912a5d63400a
Akademický článek
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Akademický článek
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Autor:
Kiminori Kimura, Akemi Ikoma, Maki Shibakawa, Shinji Shimoda, Kenichi Harada, Masanao Saio, Jun Imamura, Yosuke Osawa, Masamichi Kimura, Koji Nishikawa, Takuji Okusaka, Satoshi Morita, Kazuaki Inoue, Tatsuya Kanto, Koji Todaka, Yoichi Nakanishi, Michinori Kohara, Masashi Mizokami
Publikováno v:
EBioMedicine, Vol 23, Iss C, Pp 79-87 (2017)
Background: There is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this study was to assess the safety, tolerability, and anti-fibrotic effect of PRI-724, a small-molecule modulator of Wnt si
Externí odkaz:
https://doaj.org/article/17a6c1e0f18841c184e14890ad5fd895
Autor:
Win Sen Heng, Shiau-Chuen Cheah
Publikováno v:
Molecules, Vol 25, Iss 1, p 224 (2020)
Plant secondary metabolites have been seen as alternatives to seeking new medicines for treating various diseases. Phytochemical scientists remain hopeful that compounds isolated from natural sources could help alleviate the leading problem in oncolo
Externí odkaz:
https://doaj.org/article/748e4fcb0908497791bb54fc15aa657f
Akademický článek
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Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Intricate color patterns are a defining aspect of morphological diversity in the Felidae. We applied morphological and single-cell gene expression analysis to fetal skin of domestic cats to identify when, where, and how, during fetal development, fel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295eea8c3ac0be0a678dabf09325c726
https://doaj.org/article/3231943b00874addaa21f7041a1d1673
https://doaj.org/article/3231943b00874addaa21f7041a1d1673
Publikováno v:
Medicinal Research Reviews. 42:615-628
Skin fibrosis is the excessive deposition of extracellular matrix in the dermis. Cutaneous fibrosis can occur following tissue injury, including burns, trauma, and surgery, resulting in scars that are disfiguring, limit movement and cause significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551427170f0ba2a4bbe3d9ff81d4ec58
https://doi.org/10.1002/med.21853
https://doi.org/10.1002/med.21853
Publikováno v:
Cancer Management and Research. 12:4253-4260
The Wnt signaling pathway extensively participates in diverse processes such as embryonic development, maintenance of homeostasis and tumor pathogenesis. Dickkopf-1 (DKK1), a Wnt inhibitor, plays a vital role for over the past decades regarding its r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d3867e97e518607b72d38b66b102c20
https://doi.org/10.2147/cmar.s254596
https://doi.org/10.2147/cmar.s254596