Zobrazeno 1 - 10
of 2 915
pro vyhledávání: '"Wnt/β–Catenin pathway"'
Autor:
Zhibo Deng, Chao Song, Long Chen, Rongsheng Zhang, Linhai Yang, Peng Zhang, Yu Xiu, Yibin Su, Fenqi Luo, Jun Luo, Hanhao Dai, Jie Xu
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 6, Pp 2544-2558 (2024)
ABSTRACT Background Skeletal muscle is the primary organ involved in insulin‐mediated glucose metabolism. Elevated levels of CILP2 are a significant indicator of impaired glucose tolerance and are predominantly expressed in skeletal muscle. It rema
Externí odkaz:
https://doaj.org/article/6240973d4f20431f8f13207ebfc99b13
Publikováno v:
Cell Division, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract Background Pre-eclampsia (PE) is a pregnancy specific disease characterized by hypertension and proteinuria. The aim of this study was to investigate the effects of Zinc finger E-box binding homologous box 2 (ZEB2) on PE mice and on placenta
Externí odkaz:
https://doaj.org/article/4018a49509494dc1a19bf6726e25d46a
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Purpose Intestinal flora promotes the pathogenesis of colorectal cancer (CRC) through microorganisms and their metabolites. This study aimed to investigate the composition of intestinal flora in different stages of CRC progression and the ef
Externí odkaz:
https://doaj.org/article/9755ddf2e73b4bf4865ae5ac6d0d3118
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Esophageal cancer (EC) poses a substantial threat to human health. The development of radioresistance in esophageal cancer cells is a critical factor contributing to local treatment failure and an unfavorable prognosis in affected patients.
Externí odkaz:
https://doaj.org/article/c891d02fce524d2b8c5c679dbca67edc
Publikováno v:
Zhongguo aizheng zazhi, Vol 34, Iss 10, Pp 931-943 (2024)
Background and purpose: Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA special binding protein that participates in regulating the expression of related genes and protein translation. It has been linked to the malignant occurrence and d
Externí odkaz:
https://doaj.org/article/863ffcce94bc4fd3b21a6bcc39a6e029
Autor:
You-li Tan, Shao-hua Ju, Qiang Wang, Rui Zhong, Ji-hai Gao, Ming-jian Wang, Ya-lan Kang, Meng-zhang Xu
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract This study aimed to investigate the effects of Shuanglongjiegu pill (SLJGP) on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and explore its mechanism based on miR-217/RUNX2 axis. Results found that drug-contai
Externí odkaz:
https://doaj.org/article/33fb09ee72294a81bb2971a39f054adb
Autor:
Shi-Hua Wang, Shi-Rui Wang, Na-Na Luan, Xiao-Qian Sun, Yi-Ran Guo, Ying-Bin Yan, Su-Xia Liang
Publikováno v:
Journal of Dental Sciences, Vol 19, Iss 4, Pp 2090-2099 (2024)
Background/purpose: Dental pulp stem cells (DPSCs) have demonstrated significant potential for neuroregeneration. However, a full understanding of the specific mechanism underpinning the neural differentiation of DPSCs is still required. The Wnt sign
Externí odkaz:
https://doaj.org/article/5db5ab77939a403eb08d3d1b358d94fd
Autor:
Yang Shen, Jiayu Chen, Zhuolin Zhou, Jingyu Wu, Xinyao Hu, Yangtao Xu, Jiayi Li, Ling Wang, Siyu Wang, Shuhong Yu, Ling Feng, Ximing Xu
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Background In hepatocellular carcinoma (HCC) treatment, first-line targeted therapy in combination with immune checkpoint inhibitors (ICIs) has improved patient prognosis, but the 5-year survival rate is far from satisfactory. Studies have s
Externí odkaz:
https://doaj.org/article/79451d7af2d6417692184e0da9fb96bc
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The established association between Alzheimer's disease (AD) and compromised neural regeneration is well-documented. In addition to the mitigation of apoptosis in neural stem cells (NSCs), the induction of neurogenesis has been pr
Externí odkaz:
https://doaj.org/article/509fe601a6e7470b9ea8a790c186aa8e
Publikováno v:
Cell Division, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract Background Nuclear-enriched abundant transcript 1 (NEAT1), a long noncoding RNA (lncRNA), has been implicated in the colorectal cancer (CRC) progression. However, its upstream mechanism has not been well studied. In the present study, the fu
Externí odkaz:
https://doaj.org/article/c4b267643af3463b8aff9de76e2af49d