Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Wladimiro Jiménez"'
Autor:
Meritxell Perramón, María Navalón-López, Guillermo Fernández-Varo, Alazne Moreno-Lanceta, Rocío García-Pérez, Joana Faneca, Mario López-Moya, Cristina Fornaguera, Judith García-Villoria, Manuel Morales-Ruiz, Pedro Melgar-Lesmes, Salvador Borrós, Wladimiro Jiménez
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116143- (2024)
Nitric oxide (NO) is a small vasodilator playing a key role in the pathogenesis of portal hypertension. Here, we assessed the potential therapeutic effect of a NO donor targeted to the liver by poly(beta-amino ester) nanoparticles (pBAE NPs) in exper
Externí odkaz:
https://doaj.org/article/fd9e933b752f4fe5a4015b95496ea106
Autor:
Irene Portolés, Jordi Ribera, Esther Fernandez-Galán, Elena Lecue, Gregori Casals, Pedro Melgar-Lesmes, Guillermo Fernández-Varo, Loreto Boix, Marco Sanduzzi, Veenu Aishwarya, Maria Reig, Wladimiro Jiménez, Manuel Morales-Ruiz
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3716 (2024)
RNA helicase DHX15 plays a significant role in vasculature development and lung metastasis in vertebrates. In addition, several studies have demonstrated the overexpression of DHX15 in the context of hepatocellular carcinoma. Therefore, we hypothesiz
Externí odkaz:
https://doaj.org/article/b5b65b45f4fa4f94859aad6c338bdcb9
Autor:
Guillermo Fernández-Varo, Wladimiro Jiménez, Edward Cable, Pere Ginès, Geoff Harris, Stan Bukofzer
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115116- (2023)
The vasopressin system has emerged as a therapeutic focus for lowering portal hypertension and reducing splanchnic vasodilation in patients with refractory ascites. Clinically available vasopressin agonists are limited by preferential selectivity for
Externí odkaz:
https://doaj.org/article/9ec22a9b7de340b5b4d8c3b962a3f3bd
Autor:
Mireia Medrano-Bosch, Blanca Simón-Codina, Wladimiro Jiménez, Elazer R. Edelman, Pedro Melgar-Lesmes
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Monocytes are circulating leukocytes of innate immunity derived from the bone marrow that interact with endothelial cells under physiological or pathophysiological conditions to orchestrate inflammation, angiogenesis, or tissue remodeling. Monocytes
Externí odkaz:
https://doaj.org/article/6c10c569e8344db7aa85ca734e82f9f4
Autor:
Jordi Ribera, Irene Portolés, Bernat Córdoba-Jover, Juan Rodríguez-Vita, Gregori Casals, Bernardino González-de la Presa, Mariona Graupera, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz, José C. Fernández-Checa, Guadalupe Soria, Raúl Tudela, Anna Esteve-Codina, Guadalupe Espadas, Eduard Sabidó, Wladimiro Jiménez, William C. Sessa, Manuel Morales-Ruiz
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Jordi Ribera et al. use zebrafish and mouse models to examine the role of the ATP-dependent RNA helicase, DHX15, in vascular health. Their results suggest that DHX15 depletion can cause vascular defects in vertebrates, potentially by impacting endoth
Externí odkaz:
https://doaj.org/article/60371e2857454f899a27accdb598b3f6
Autor:
Alazne Moreno-Lanceta, Mireia Medrano-Bosch, Blanca Simón-Codina, Montserrat Barber-González, Wladimiro Jiménez, Pedro Melgar-Lesmes
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1452 (2023)
Macrophages play essential roles during the progression of chronic liver disease. They actively participate in the response to liver damage and in the balance between fibrogenesis and regression. The activation of the PPARγ nuclear receptor in macro
Externí odkaz:
https://doaj.org/article/edd95e9aa11840528f6c104c74d88471
Autor:
Lena M. Ernst, Laura Mondragón, Joana Ramis, Muriel F. Gustà, Tetyana Yudina, Eudald Casals, Neus G. Bastús, Guillermo Fernández-Varo, Gregori Casals, Wladimiro Jiménez, Victor Puntes
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 765 (2023)
Nanoparticle (NP) pharmacokinetics significantly differ from traditional small molecule principles. From this emerges the need to create new tools and concepts to harness their full potential and avoid unnecessary risks. Nanoparticle pharmacokinetics
Externí odkaz:
https://doaj.org/article/7dd6ac6461cf496f97acc0d66699be14
Autor:
Valeria Opazo-Toro, Virginia Fortuna, Wladimiro Jiménez, Marta Pazos López, María Jesús Muniesa Royo, Néstor Ventura-Abreu, Mercè Brunet, Elena Milla
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2093 (2023)
Analysis of the genotype that predicts the phenotypic characteristics of a cohort of glaucoma and ocular hypertension patients, and the correlation with their personal pharmacological response to beta-blockers (BB) and prostaglandin analogues (PGA).
Externí odkaz:
https://doaj.org/article/6b08405a1a2149ff90aa8d0ea11d7a2b
Autor:
Bernat Córdoba-Jover, Altamira Arce-Cerezo, Jordi Ribera, Montse Pauta, Denise Oró, Gregori Casals, Guillermo Fernández-Varo, Eudald Casals, Victor Puntes, Wladimiro Jiménez, Manuel Morales-Ruiz
Publikováno v:
Journal of Nanobiotechnology, Vol 17, Iss 1, Pp 1-12 (2019)
Abstract Background and aims Cerium oxide nanoparticles are effective scavengers of reactive oxygen species and have been proposed as a treatment for oxidative stress-related diseases. Consequently, we aimed to investigate the effect of these nanopar
Externí odkaz:
https://doaj.org/article/7f909eb33ae542cbac680be23ade6ce0
Autor:
Meritxell Perramón, Wladimiro Jiménez
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6897 (2022)
The management of chronic liver diseases (CLDs) remains a challenge, and identifying effective treatments is a major unmet medical need. In the current review we focus on the pituitary tumor transforming gene (PTTG1)/delta like non-canonical notch li
Externí odkaz:
https://doaj.org/article/fafab2241a3548f8994dcc228eda0e04