Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy

Autor: Mb, Pepys, Ga, Tennent, Dr, Booth, Bellotti V, Laurence Lovat, Sy, Tan, Persey MR, Wl, Hutchinson, Se, Booth, Madhoo S, Ak, Soutar, Pn, Hawkins, Van Zyl-Smit R, Jm, Campistol, Pe, Fraser, Se, Radford, Cv, Robinson, Sunde M, Lc, Serpell, Cc, Blake

Publikováno v: Europe PubMed Central

Amyloid deposits regress when the supply of fibril precursor proteins is sufficiently reduced, indicating that amyloid fibrils are degradable in vivo. Serum amyloid P component (SAP), a universal constituent of amyloid deposits, efficiently protects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::01e3af960530a2a6a66565f0ac41982f
https://pubmed.ncbi.nlm.nih.gov/8915605

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Immunoradiometric assay for human serum amyloid P component.

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Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE-/- mice.

Autor: Tennent GA; Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, UK. Electronic address: g.tennent@medsch.ucl.ac.uk., Hutchinson WL; Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, UK., Kahan MC; Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, UK., Hirschfield GM; Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, UK., Gallimore JR; Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, UK., Lewin J; Electron Microscopy Unit, University College London, UK., Sabin CA; Department of Primary Care and Population Sciences, University College London, UK., Dhillon AP; Department of Histopathology, University College London, UK., Pepys MB; Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, UK.

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