Zobrazeno 1 - 10 of 316 pro vyhledávání: '"Wk, Cavenee"'
1
Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR
Autor: Rb, Luwor, Tg, Johns, Murone C, Hj, Huang, Wk, Cavenee, Ritter G, Lj, Old, Aw, Burgess, Andrew Scott
Publikováno v: Europe PubMed Central
The monoclonal antibody (mAb) 806 was raised against the delta2-7 epidermal growth factor receptor (de2-7 EGFR or EGFRvIII), a truncated version of the EGFR commonly expressed in glioma. Unexpectedly, mAb 806 also bound the EGFR expressed by cells ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::292be7356489408a0c2111c84ddf8c70
https://pubmed.ncbi.nlm.nih.gov/11454674
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2
Analysis of the p53 gene and its expression in human glioblastoma cells
Autor: Erwin G. Van Meir, Kikuchi T, Tada M, Li H, Ac, Diserens, Be, Wojcik, Hj, Huang, Friedmann T, de Tribolet N, Wk, Cavenee
Publikováno v: Europe PubMed Central
Chromosome 17p has been shown to be an early and frequent target for loss of heterozygosity through mitotic recombination in astrocytomas. These losses are frequently accompanied by point mutations in the p53 gene of the remaining allele, resulting i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::98c3bdf461741f893c1b7bad010901c8
http://europepmc.org/abstract/med/8306326
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4
Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor
Autor: Mishima K, Tg, Johns, Rb, Luwor, Andrew Scott, Stockert E, Aa, Jungbluth, Xd, Ji, Suvarna P, Jr, Voland, Lj, Old, Hj, Huang, Wk, Cavenee
Publikováno v: Europe PubMed Central
A mutant epidermal growth factor receptor (variously called DeltaEGFR, de2-7 EGFR, or EGFRvIII) containing a deletion of 267 amino acids of the extracellular domain is frequently highly expressed in human malignant gliomas and has been reported for c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ebe7b825a7ff57a198d2cc069cb0cd15
http://europepmc.org/abstract/med/11454673
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5
Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of the p53 gene
Autor: Kikuchi T, Sa, Rempel, Hp, Rutz, de Tribolet N, Mulligan L, Wk, Cavenee, Jothy S, Leduy L, Erwin G. Van Meir
Publikováno v: Europe PubMed Central
The term "Turcot's syndrome" has been used to describe approximatively 55 patients with an association of colonic polyposis and primary neuroepithelial tumors of the central nervous system. The p53 tumor suppressor gene is a possible candidate underl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3774ff5f988214cefe76d96a0f00f48e
http://europepmc.org/abstract/med/8439970
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6
Akademický článek
Noninvasive therapy of brain cancer using a unique systemic delivery methodology with a cancer terminator virus.
Autor: Bhoopathi P; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA., Mannangatti P; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA., Pradhan AK; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA., Kumar A; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA., Maji S; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA., Lang FF; Department of Neurosurgery, MD Anderson Cancer Center, Houston, Texas, USA., Klibanov AL; Biomedical Engineering, Radiology and Medical Imaging, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA., Madan E; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; Department of Surgery, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA., Cavenee WK; Ludwig Institute for Cancer Research, University of San Diego, La Jolla, California, USA., Keoprasert T; Department of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA., Sun D; Department of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA., Bjerkvig R; Department of Biomedicine, Kristian Gerhard Jebsen Brain Tumour Research Centre, University of Bergen, Bergen, Norway., Thorsen F; Department of Biomedicine, Kristian Gerhard Jebsen Brain Tumour Research Centre, University of Bergen, Bergen, Norway., Gogna R; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA., Das SK; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA., Emdad L; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA., Fisher PB; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.
Publikováno v: Journal of cellular physiology [J Cell Physiol] 2024 Aug; Vol. 239 (8), pp. e31302. Date of Electronic Publication: 2024 May 22.
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7
Akademický článek
DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma.
Autor: Harachi M; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan., Masui K; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan. masui-kn@twmu.ac.jp., Shimizu E; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan., Murakami K; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan., Onizuka H; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan., Muragaki Y; Department of Neurosurgery, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.; Center for Advanced Medical Engineering Research and Development, Kobe University, Kobe, Hyogo, 650-0047, Japan., Kawamata T; Department of Neurosurgery, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan., Nakayama H; Department of Physiology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan., Miyata M; Department of Physiology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan., Komori T; Department of Neuropathology, Tokyo Metropolitan Neurological Hospital, Musashinodai, Tokyo, 156-8506, Japan., Cavenee WK; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, 92093, USA., Mischel PS; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Kurata A; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan., Shibata N; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Mar 13; Vol. 12 (1), pp. 40. Date of Electronic Publication: 2024 Mar 13.
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8
Akademický článek
MDA-9/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis.
Autor: Maji S; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Pradhan AK; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Kumar A; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Bhoopathi P; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Mannangatti P; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Guo C; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Windle JJ; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Subler MA; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Wang XY; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Semmes OJ; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507., Nyalwidhe JO; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507., Mukhopadhyay N; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; Department of Biostatistics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23238., Paul AK; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; Department of Internal Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23238., Hatfield B; Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23238., Levit MM; Department of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23238., Madan E; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; Department of Surgery, Virginia Commonwealth University, School of Medicine, Richmond, VA 23238., Sarkar D; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Emdad L; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Cohen DJ; Department of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23238., Gogna R; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Cavenee WK; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093., Das SK; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Fisher PB; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Nov 07; Vol. 120 (45), pp. e2307094120. Date of Electronic Publication: 2023 Nov 03.
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9
Akademický článek
Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts.
Autor: Lauer RC; University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States.; Division of Hematology/Oncology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States., Barry M; Department of Pathology, University of Utah, Salt Lake City, Utah, United States., Smith TL; Rutgers Cancer Institute of New Jersey, Newark, New Jersey, United States.; Division of Cancer Biology, Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, New Jersey, United States., Thomas AM; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Wu J; University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States.; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States., Du R; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States., Lee JH; Department of Biostatistics, University of Florida, Gainesville, Florida, United States.; Division of Quantitative Sciences, University of Florida Health Cancer Center, Gainesville, Florida, United States., Rao A; Section of Hematology and Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States., Dobroff AS; University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States.; Division of Molecular Medicine, Department of Medicine, Albuquerque, United States., Arap MA; Division of Urology, University of São Paulo Medical School, São Paulo, Brazil.; Syrian-Lebanese Hospital, São Paulo, Brazil., Nunes DN; Laboratory of Medical Genomics, A.C. Camargo Cancer Center, São Paulo, Brazil., Silva IT; Laboratory of Bioinformatics and Computational Biology, A.C. Camargo Cancer Center, São Paulo, Brazil., Dias-Neto E; Laboratory of Medical Genomics, A.C. Camargo Cancer Center, São Paulo, Brazil., Chen I; MBrace Therapeutics, San Diego, California, United States., McCance DJ; University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States.; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States., Cavenee WK; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California, United States., Pasqualini R; Rutgers Cancer Institute of New Jersey, Newark, New Jersey, United States.; Division of Cancer Biology, Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, New Jersey, United States., Arap W; Rutgers Cancer Institute of New Jersey, Newark, New Jersey, United States.; Division of Hematology/Oncology, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, United States.
Publikováno v: ELife [Elife] 2023 Jan 16; Vol. 12. Date of Electronic Publication: 2023 Jan 16.
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10
Akademický článek
Somatic 9p24.1 alterations in HPV - head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity.
Autor: Zhao X; Department of Biochemistry and Molecular Pharmacology, Institute for Systems Genetics, New York University Langone Health, New York, NY 10016., Cohen EEW; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037.; Department of Medicine, University of California San Diego, La Jolla, CA 92037., William WN Jr; Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.; Hospital BP, a Beneficência Portuguesa de São Paulo, 01323-001 São Paulo, Brazil., Bianchi JJ; Department of Biochemistry and Molecular Pharmacology, Institute for Systems Genetics, New York University Langone Health, New York, NY 10016., Abraham JP; Research and Development, Caris Life Sciences, Irving, TX 75039., Magee D; Research and Development, Caris Life Sciences, Irving, TX 75039., Spetzler DB; Research and Development, Caris Life Sciences, Irving, TX 75039., Gutkind JS; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037.; Department of Pharmacology, University of California San Diego, La Jolla, CA 92037., Alexandrov LB; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037.; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92037.; Department of Bioengineering, University of California San Diego, La Jolla, CA 92037., Cavenee WK; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037.; Department of Medicine, University of California San Diego, La Jolla, CA 92037.; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92037., Lippman SM; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037.; Department of Medicine, University of California San Diego, La Jolla, CA 92037.; Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030., Davoli T; Department of Biochemistry and Molecular Pharmacology, Institute for Systems Genetics, New York University Langone Health, New York, NY 10016.
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Nov 22; Vol. 119 (47), pp. e2213835119. Date of Electronic Publication: 2022 Nov 17.
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