Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Wiweka Kaszubska"'
Autor:
Jane Achan, Aïssata Barry, Didier Leroy, George Kamara, Stephan Duparc, Wiweka Kaszubska, Preetam Gandhi, Bénédicte Buffet, Patrick Tshilab, Bernhards Ogutu, Terrie Taylor, Sanjeev Krishna, Naomi Richardson, Hanu Ramachandruni, Hans Rietveld
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Background Severe malaria is a life-threatening infection, particularly affecting children under the age of 5 years in Africa. Current treatment with parenteral artemisinin derivatives is highly efficacious. However, artemisinin partial resi
Externí odkaz:
https://doaj.org/article/cdf818acf782442390d2250921fd36ad
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-7 (2022)
Abstract Malaria is one of the most serious infectious diseases affecting predominantly low- and middle-income countries, where pregnant women are among the populations at risk. There are limited options to prevent or treat malaria in pregnancy, part
Externí odkaz:
https://doaj.org/article/2c424d08462e4d6fb07e3f04dc4e99ff
Autor:
Fiona Macintyre, Hanu Ramachandruni, Jeremy N. Burrows, René Holm, Anna Thomas, Jörg J. Möhrle, Stephan Duparc, Rob Hooft van Huijsduijnen, Brian Greenwood, Winston E. Gutteridge, Timothy N. C. Wells, Wiweka Kaszubska
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-18 (2018)
Abstract Over the last 15 years, the majority of malaria drug discovery and development efforts have focused on new molecules and regimens to treat patients with uncomplicated or severe disease. In addition, a number of new molecular scaffolds have b
Externí odkaz:
https://doaj.org/article/dbdcceb481fa497fa620c83328de23ba
Autor:
Jeremy N. Burrows, Stephan Duparc, Winston E. Gutteridge, Rob Hooft van Huijsduijnen, Wiweka Kaszubska, Fiona Macintyre, Sébastien Mazzuri, Jörg J. Möhrle, Timothy N. C. Wells
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-5 (2017)
Externí odkaz:
https://doaj.org/article/0db67e0cbf7c4a8ba7a34e1ed7147e7b
Autor:
Rob Hooft van Huijsduijnen, Jeremy N. Burrows, Stephan Duparc, Wiweka Kaszubska, Sébastien Mazzuri, Timothy N. C. Wells, Fiona Macintyre, Winston E. Gutteridge, Jörg J. Möhrle
Publikováno v:
Malaria Journal
A decade of discovery and development of new anti-malarial medicines has led to a renewed focus on malaria elimination and eradication. Changes in the way new anti-malarial drugs are discovered and developed have led to a dramatic increase in the num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275bb13a41c3095a2508a09735640cf6
https://doi.org/10.1186/s12936-016-1675-x
https://doi.org/10.1186/s12936-016-1675-x
Autor:
Christopher A. Ogiela, Verlyn G. Schaefer, Regina M. Reilly, H. Douglas Falls, Sevan Brodjian, Christine A. Collins, Brian D. Dayton, Dennis G Fry, Wiweka Kaszubska
Publikováno v:
Journal of Molecular Endocrinology. 37:51-62
Ghrelin, a 28 amino acid, octanoylated peptide, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). In addition to various endocrine functions, including stimulation of GH release, ghrelin has been characterized as an import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2413c63ba94a30c996214e7be9ed85b3
https://doi.org/10.1677/jme.1.01943
https://doi.org/10.1677/jme.1.01943
Autor:
Verlyn G. Schaefer, Michael D. Serby, Bo Liu, Christine A. Collins, H. Douglas Falls, Hongyu Zhao, Eugene N. Bush, Victoria Knourek-Segel, Theresa M Turner, Michael E. Brune, Gang Liu, Thomas A. Fey, Wiweka Kaszubska, Brian A. Droz, Christi Kosogof, Zhili Xin, David W A Beno, Robin Shapiro, Peer B. Jacobson, Bruce G. Szczepankiewicz, Mei Liu, Nelson Lissa T, Hing L. Sham
Publikováno v:
Journal of Medicinal Chemistry. 49:2568-2578
Ghrelin, a gut-derived orexigenic hormone, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Centrally administered ghrelin has been shown to cause hunger and increase food intake in rodents. Inhibition of ghrelin actions w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d352477e306be3be634175471489d0
https://doi.org/10.1021/jm0510934
https://doi.org/10.1021/jm0510934
Autor:
Zhili Xin, Cele Abad-Zapatero, James M. Trevillyan, Cristina M. Rondinone, Hongyu Zhao, Zhonghua Pei, Thomas H. Lubben, Wiweka Kaszubska, Deanna L. Haasch, Gang Liu, Michael R. Jirousek, Stephen J. Ballaron, Charles W. Hutchins, Philip J. Hajduk
Publikováno v:
Journal of Medicinal Chemistry. 46:4232-4235
Using an NMR-based fragment screening and X-ray crystal structure-based assembly, starting with millimolar ligands for both the catalytic site and the second phosphotyrosine binding site, we have identified a small-molecule inhibitor of protein tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3550c28945a5509a551fdcab3473256
https://doi.org/10.1021/jm034122o
https://doi.org/10.1021/jm034122o
Autor:
Robert L. Patterson, Gregory F. Okasinski, Haiying Zhang, Deanna L. Haasch, Meuth Joseph L, Devries Peter J, Richard S. Janis, Robert W. Dickinson, Marie E. Uchic, Verlyn G. Schaefer, Thomas S. Suhar, Wiweka Kaszubska
Publikováno v:
Protein Expression and Purification. 18:213-220
Thrombopoietin (TPO) is a primary regulator of megakaryocytopoiesis, a process through which megakaryocytes proliferate and mature into platelets. Recombinant human TPO (rhTPO) was expressed in Chinese hamster ovary (CHO) cells and purified from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f6e7df5a05bc32a1f4531a1d2b3ccd
https://doi.org/10.1006/prep.1999.1190
https://doi.org/10.1006/prep.1999.1190
Autor:
Wiweka Kaszubska, Verlyn G. Schaefer, Zhili Xin, H. Douglas Falls, Hongyu Zhao, Christine A. Collins, Gang Liu, Hing L. Sham
Publikováno v:
Journal of Medicinal Chemistry. 47:6655-6657
A case study of rational design of an efficient, specific, and proprietary molecular scaffold based on the structure-activity relationship (SAR) information on a screening hit is described. Potent, selective, and orally bioavailable tetralin carboxam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a21c31e217c53a8eb190421dd65f3e
https://doi.org/10.1021/jm0491750
https://doi.org/10.1021/jm0491750