Promotion of joint degeneration and chondrocyte metabolic dysfunction by excessive growth hormone in mice

Autor: Zhu, S., Liu, H., Davis, T., Willis, Craig R.G., Basu, R., Witzigreuter, L., Bell, S., Szewczyk, N., Lotz, M.K., Hill, M., Fajardo, R.J., O'Connor, P.M., Berryman, D.E., Kopchick, J.J.

Yes
Objective: Many patients with acromegaly, a hormonal disorder with excessive growth hormone (GH) production, report pain in joints. We undertook this study to characterize the joint pathology of mice with overexpression of bovine GH (bGH) or

Externí odkaz: http://hdl.handle.net/10454/19398

Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice.

Autor: Zhu S; Department of Biomedical Sciences and Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens., Liu H; Department of Biomedical Sciences and Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens., Davis T; Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens., Willis CRG; Department of Biomedical Sciences and Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, and School of Chemistry and Biosciences, Faculty of Life Sciences, University of Bradford, Bradford, UK., Basu R; Edison Biotechnology Institute, Ohio University, Athens., Witzigreuter L; Department of Biological Sciences, Ohio University, Athens., Bell S; Edison Biotechnology Institute, Ohio University, Athens., Szewczyk N; Department of Biomedical Sciences and Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens., Lotz MK; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California., Hill M; School of Osteopathic Medicine, University of the Incarnate Word, San Antonio, Texas., Fajardo RJ; School of Osteopathic Medicine, University of the Incarnate Word, San Antonio, Texas., O'Connor PM; Department of Biomedical Sciences, Ohio University, Athens., Berryman DE; Department of Biomedical Sciences, Edison Biotechnology Institute, and Diabetes Institute, Ohio University, Athens., Kopchick JJ; Department of Biomedical Sciences, Edison Biotechnology Institute, and Diabetes Institute, Ohio University, Athens.

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2023 Jul; Vol. 75 (7), pp. 1139-1151. Date of Electronic Publication: 2023 Apr 27.