Human TRMT2A methylates tRNA and contributes to translation fidelity

Autor: Witzenberger, M., Burczyk, S., Settele, D., Mayer, W., Welp, L., Heiss, M., Wagner, M., Monecke, T., Janowski, R., Carell, T., Urlaub, H., Hauck, S., Voigt, A., Niessing, D.

Publikováno v: Nucleic Acids Research

5-Methyluridine (m5U) is one of the most abundant RNA modifications found in cytosolic tRNA. tRNA methyltransferase 2 homolog A (hTRMT2A) is the dedicated mammalian enzyme for m5U formation at tRNA position 54. However, its RNA binding specificity an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1874::37eec37c21e807800f1f83e756730a30
https://hdl.handle.net/21.11116/0000-000D-70A7-821.11116/0000-000D-70A9-6

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Crystal structure of the RNA-recognition motif of Drosophila melanogaster tRNA (uracil-5-)-methyltransferase homolog A.

Autor: Witzenberger M; Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85764 Munich, Germany., Janowski R; Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85764 Munich, Germany., Niessing D; Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85764 Munich, Germany.

Publikováno v: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2024 Feb 01; Vol. 80 (Pt 2), pp. 36-42. Date of Electronic Publication: 2024 Jan 25.

Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death.

Autor: Margreiter MA; Institute of Neuroscience and Medicine (INM-9), Forschungszentrum Juelich GmbH, Germany.; Faculty of Mathematics, Computer Science and Natural Sciences, RWTH Aachen, 52425 Aachen, Germany., Witzenberger M; Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Structural Biology, 85764 Neuherberg, Germany., Wasser Y; Department of Neurology, RWTH University Aachen, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany., Davydova E; Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Structural Biology, 85764 Neuherberg, Germany., Janowski R; Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Structural Biology, 85764 Neuherberg, Germany., Metz J; Institute of Neuroscience and Medicine (INM-9), Forschungszentrum Juelich GmbH, Germany., Habib P; Department of Neurology, RWTH University Aachen, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany.; JARA - BRAIN - Translational Medicine, Aachen, Germany., Sahnoun SEM; Department of Nuclear Medicine, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany., Sobisch C; Department of Neurology, RWTH University Aachen, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany., Poma B; Department of Neurology, RWTH University Aachen, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany., Palomino-Hernandez O; Institute of Neuroscience and Medicine (INM-9), Forschungszentrum Juelich GmbH, Germany.; Faculty of Mathematics, Computer Science and Natural Sciences, RWTH Aachen, 52425 Aachen, Germany., Wagner M; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377 München, Germany., Carell T; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377 München, Germany., Jon Shah N; JARA - BRAIN - Translational Medicine, Aachen, Germany.; Institute of Neuroscience and Medicine (INM-4), Forschungszentrum Juelich GmbH, Germany.; Institute of Neuroscience and Medicine (INM-11), Forschungszentrum Juelich GmbH, Germany., Schulz JB; Department of Neurology, RWTH University Aachen, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany.; JARA - BRAIN - Translational Medicine, Aachen, Germany.; Institute of Neuroscience and Medicine (INM-11), Forschungszentrum Juelich GmbH, Germany., Niessing D; Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Structural Biology, 85764 Neuherberg, Germany.; Institute of Pharmaceutical Biotechnology, Ulm University, 89081 Ulm, Germany., Voigt A; Department of Neurology, RWTH University Aachen, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany.; JARA - BRAIN - Translational Medicine, Aachen, Germany., Rossetti G; Institute of Neuroscience and Medicine (INM-9), Forschungszentrum Juelich GmbH, Germany.; Department of Neurology, RWTH University Aachen, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany.; Juelich Supercomputing Center (JSC), Forschungszentrum Juelich GmbH, Germany.; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany.

Publikováno v: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2021 Dec 28; Vol. 20, pp. 443-458. Date of Electronic Publication: 2021 Dec 28 (Print Publication: 2022).