Výsledky vyhledávání - "Wittrup, Karl Dane"

Akademický článek

Dose Dependence of Intratumoral Perivascular Distribution of Monoclonal Antibodies

Autor: Rhoden, John J., Wittrup, Karl Dane ^*

Publikováno v: In Journal of Pharmaceutical Sciences February 2012 101(2):860-867

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Dissertation/ Thesis

Plasmid Propagation in the Yeast Saccharomyces cerevisiae: Flow Cytometry Studies and Segregated Modeling

Autor: Wittrup, Karl Dane

The baker's yeast Saccharomyces cerevisiae is potentially a very useful host for the production of pharmaceutical proteins by recombinant DNA technology. One requirement for efficient overproduction of a foreign protein in yeast is a stable recombina

Externí odkaz: https://thesis.library.caltech.edu/697/5/winckelmans-gs_1989.pdf

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Akademický článek

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Akademický článek

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Temporally Programmed CD8α+ DC Activation Enhances Combination Cancer Immunotherapy

Autor: Szeto, Gregory L., Overwijk, Willem W., Tzeng, Alice, Kauke, Monique Jacqueline, Zhu, Eric Franklin, Moynihan, Kelly Dare, Opel, Cary Francis, Yang, Nicole Jie Yeon, Mehta, Naveen, Irvine, Darrell J, Wittrup, Karl Dane

Publikováno v: Elsevier

Numerous synergistic cancer immunotherapy combinations have been identified, but the effects of relative dose timing are rarely considered. In established syngeneic mouse tumor models, we found that staggering interferon-α (IFNα) administration aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od________88::c775df62701f98c2d930297ab4c2d0c2
https://orcid.org/0000-0001-7316-6923

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Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity 86Y- or 177Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates

Autor: Xu, Hong, Guo, Hong-fen, Lee, Sang-gyu, Punzalan, Blesida, Chalasani, Sandhya, Jungbluth, Achim, O’Donoghue, Joseph, Cheal, Sarah M., Fung, Edward K., Zanzonico, Pat B., Carrasquillo, Jorge A., Smith-Jones, Peter M., Cheung, Nai-Kong V., Larson, Steven M., Wittrup, Karl Dane

Publikováno v: Springer Berlin Heidelberg

Purpose: GPA33 is a colorectal cancer (CRC) antigen with unique retention properties after huA33-mediated tumor targeting. We tested a pretargeted radioimmunotherapy (PRIT) approach for CRC using a tetravalent bispecific antibody with dual specificit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od________88::85c198e06bbf99ab34fecc86158329c8
http://hdl.handle.net/1721.1/104432

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CD8[superscript +] T-cell Responses Rapidly Select for Antigen-Negative Tumor Cells in the Prostate

Autor: Bak, S. Peter G., Barnkob, Mike Stein, Wittrup, Karl Dane, Chen, Jianzhu

Publikováno v: PMC

Stimulation of patients' immune systems for the treatment of solid tumors is an emerging therapeutic paradigm. The use of enriched autologous T cells for adoptive cell therapy or vaccination with antigen-loaded dendritic cells have shown clinical eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od________88::8243dc77119a2618c11a3a782000de8b
https://orcid.org/0000-0003-2398-5896

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Determination of 35 cell surface antigen levels in malignant pleural effusions identifies CD24 as a marker of disseminated tumor cells

Autor: Yao, Xiaosai, Labelle, Myriam, Lamb, Carla R., Dugan, John M., Williamson, Christina A., Spencer, Donna R., Christ, Kimberly R., Keating, Ryan O., Lee, W. David, Paradis, Glenn A., Begum, Shahinoor, Wittrup, Karl Dane, Hynes, Richard O

Publikováno v: PMC

Many targets have been identified in solid tumors for antibody therapy but it is less clear what surface antigens may be most commonly expressed on disseminated tumor cells. Using malignant pleural effusions as a source of disseminated tumor cells, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::28a09442a3cfd4c7db4038a5e9d141e3
https://europepmc.org/articles/PMC4107365/

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Targeted Cytolysins Synergistically Potentiate Cytoplasmic Delivery of Gelonin Immunotoxin

Autor: Wittrup, K. D., Pirie, Christopher M., Liu, David V., Wittrup, Karl Dane

Publikováno v: PMC

Targeted endocytic uptake is a first step toward tissue-specific cytoplasmic macromolecular delivery; however, inefficient escape from the endolysosomal compartment makes this generally impractical at present. We report here a targeted cytolysin appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b5b1f51ac49d6689f38e532e3241f9
https://orcid.org/0000-0003-2398-5896

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