Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy.

Autor: Rivas VN; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Dr, Raleigh, NC, 27607, USA.; Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA., Crofton AE; Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA., Jauregui CE; Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA., Wouters JR; Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA., Yang BS; Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA., Wittenburg LA; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA., Kaplan JL; Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA., Hwee DT; Research and Non-Clinical Development, Cytokinetics, Inc., South San Francisco, CA, USA., Murphy AN; Research and Non-Clinical Development, Cytokinetics, Inc., South San Francisco, CA, USA., Morgan BP; Research and Non-Clinical Development, Cytokinetics, Inc., South San Francisco, CA, USA., Malik FI; Research and Non-Clinical Development, Cytokinetics, Inc., South San Francisco, CA, USA., Harris SP; Department of Physiology, University of Arizona, Tucson, AZ, USA., Stern JA; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Dr, Raleigh, NC, 27607, USA. jastern@ncsu.edu.; Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA. jastern@ncsu.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 May 27; Vol. 14 (1), pp. 12038. Date of Electronic Publication: 2024 May 27.

Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue-specific drug binding, transport, and metabolism.

Autor: Witta S; Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, USA., Collins KP; Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, USA., Ramirez DA; Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA., Mannheimer JD; Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, USA., Wittenburg LA; Department of Surgical and Radiological Sciences, University of California, Davis, California, USA.; University of California, Davis Comprehensive Cancer Center, Sacramento, California, USA., Gustafson DL; Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, USA.; Developmental Therapeutics Program, University of Colorado Cancer Center, Aurora, Colorado, USA.; Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, USA.

Publikováno v: Pharmacology research & perspectives [Pharmacol Res Perspect] 2023 Feb; Vol. 11 (1), pp. e01052.

Microglia-Derived Olfactomedin-like 3 Is a Potent Angiogenic Factor in Primary Mouse Brain Endothelial Cells: A Novel Target for Glioblastoma.

Autor: Joseph LM; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA., Toedebusch RG; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA., Debebe E; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA., Bastian AH; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA., Lucchesi CA; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA., Syed-Quadri S; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA., Wittenburg LA; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.; Comprehensive Cancer Center, Davis School of Medicine, University of California, Sacramento, CA 95817, USA., Chen X; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.; Comprehensive Cancer Center, Davis School of Medicine, University of California, Sacramento, CA 95817, USA., Meyers FJ; Comprehensive Cancer Center, Davis School of Medicine, University of California, Sacramento, CA 95817, USA.; Department of Internal Medicine, Division of Hematology and Oncology, Center for Precision Medicine, Davis School of Medicine, University of California, Sacramento, CA 95817, USA., Toedebusch CM; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.; Comprehensive Cancer Center, Davis School of Medicine, University of California, Sacramento, CA 95817, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 23; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 23.

Population pharmacokinetics identifies rapid gastrointestinal absorption and plasma clearance of oral chlorambucil administered to cats with indolent lymphoproliferative malignancies.

Autor: Al-Nadaf S; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA., Wittenburg LA; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA., Skorupski KA; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA., Burton JH; Department of Clinical Sciences, Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.

Publikováno v: American journal of veterinary research [Am J Vet Res] 2022 Sep 29; Vol. 83 (11), pp. 1-9. Date of Electronic Publication: 2022 Sep 29.

Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response.

Autor: Rebhun RB; Department of Surgical and Radiological Sciences, University of California, Davis, California, USA rbrebhun@ucdavis.edu rjcanter@ucdavis.edu., York D; Department of Surgical and Radiological Sciences, University of California, Davis, California, USA., Cruz SM; Division of Surgical Oncology, Department of Surgery, University of California Davis Medical Center, Sacramento, California, USA., Judge SJ; Division of Surgical Oncology, Department of Surgery, University of California Davis Medical Center, Sacramento, California, USA., Razmara AM; Division of Surgical Oncology, Department of Surgery, University of California Davis Medical Center, Sacramento, California, USA., Farley LE; Division of Surgical Oncology, Department of Surgery, University of California Davis Medical Center, Sacramento, California, USA., Brady RV; College of Veterinary Medicine, Colorado State University, Fort Collins, Colorado, USA., Johnson EG; Department of Surgical and Radiological Sciences, University of California, Davis, California, USA., Burton JH; Department of Clinical Sciences, Colorado State University College of Veterinary Medicine, Fort Collins, Colorado, USA., Willcox J; Department of Surgical and Radiological Sciences, University of California, Davis, California, USA., Wittenburg LA; Department of Surgical and Radiological Sciences, University of California, Davis, California, USA., Woolard K; Department of Pathology, University of California, Davis, California, USA., Dunai C; Department of Dermatology, University of California, Davis, California, USA., Stewart SL; Department of Public Health Sciences, University of California, Davis, California, USA., Sparger EE; Department of Medicine and Epidemiology, University of California, Davis, California, USA., Withers SS; Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, Louisiana, USA., Gingrich AA; Division of Surgical Oncology, Department of Surgery, University of California Davis Medical Center, Sacramento, California, USA., Skorupski KA; Department of Surgical and Radiological Sciences, University of California, Davis, California, USA., Al-Nadaf S; Department of Surgical and Radiological Sciences, University of California, Davis, California, USA., LeJeune AT; Department of Surgical and Radiological Sciences, University of California, Davis, California, USA., Culp WT; Department of Surgical and Radiological Sciences, University of California, Davis, California, USA., Murphy WJ; Department of Dermatology, University of California Davis Medical Center, Sacramento, California, USA.; Division of Hematology and Oncology, Department of Medicine, University of California Davis Medical Center, Sacramento, California, USA., Kent MS; Department of Surgical and Radiological Sciences, University of California, Davis, California, USA., Canter RJ; Division of Surgical Oncology, Department of Surgery, University of California, Davis, California, USA rbrebhun@ucdavis.edu rjcanter@ucdavis.edu.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2022 Jun; Vol. 10 (6).