Zobrazeno 1 - 10
of 400
pro vyhledávání: '"Witte, Js"'
Autor:
Gabriel, AAG, Atkins, JR, Penha, RCC, Smith-Byrne, K, Gaborieau, V, Voegele, C, Abedi-Ardekani, B, Milojevic, M, Olaso, R, Meyer, V, Boland, A, Deleuze, JF, Zaridze, D, Mukeriya, A, Swiatkowska, B, Janout, V, Schejbalová, M, Mates, D, Stojšić, J, Ognjanovic, M, consortium, ILCCO, Witte, JS, Rashkin, SR, Kachuri, L, Hung, RJ, Kar, S, Brennan, P, Sertier, A-S, Ferrari, A, Viari, A, Johansson, M, Amos, CI, Foll, M, McKay, JD
Publikováno v:
Gabriel, A A G, Atkins, J R, Penha, R C C, Smith Byrne, K, Kar, S, McKay, J D & et, A 2022, ' Genetic analysis of lung cancer and the germline impact on somatic mutation burden ', Journal of the National Cancer Institute, vol. 114, no. 8, pp. 1159-1166 . https://doi.org/10.1093/jnci/djac087
JNCI: Journal of the National Cancer Institute
JNCI: Journal of the National Cancer Institute, 2022, 114 (8), pp.1159-1166. ⟨10.1093/jnci/djac087⟩
JNCI: Journal of the National Cancer Institute
JNCI: Journal of the National Cancer Institute, 2022, 114 (8), pp.1159-1166. ⟨10.1093/jnci/djac087⟩
Background Germline genetic variation contributes to lung cancer (LC) susceptibility. Previous genome-wide association studies (GWAS) have implicated susceptibility loci involved in smoking behaviors and DNA repair genes, but further work is required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9568c690878bbd01ed4e016717346c0
https://research-information.bris.ac.uk/ws/files/327769434/Full_text_PDF_final_published_version_.pdf
https://research-information.bris.ac.uk/ws/files/327769434/Full_text_PDF_final_published_version_.pdf
Autor:
McAllister, K, Mechanic, LE, Amos, C, Aschard, H, Blair, IA, Chatterjee, N, Conti, D, Gauderman, WJ, Hsu, L, Hutter, CM, Jankowska, MM, Kerr, J, Kraft, P, Montgomery, SB, Mukherjee, B, Papanicolaou, GJ, Patel, CJ, Ritchie, MD, Ritz, BR, Thomas, DC, Wei, P, Witte, JS, Participants, W
Publikováno v:
McAllister, K; Mechanic, LE; Amos, C; Aschard, H; Blair, IA; Chatterjee, N; et al.(2017). Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. AMERICAN JOURNAL OF EPIDEMIOLOGY, 186(7), 753-761. doi: 10.1093/aje/kwx227. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9731f4gk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::b9ce4e8bbcc604b29a5ca4570ca6ff0b
http://www.escholarship.org/uc/item/9731f4gk
http://www.escholarship.org/uc/item/9731f4gk
Autor:
Ng, MCY, Graff, M, Lu, Y, Justice, AE, Mudgal, P, Liu, CT, Young, K, Yanek, LR, Feitosa, MF, Wojczynski, MK, Rand, K, Brody, JA, Cade, BE, Dimitrov, L, Duan, Q, Guo, X, Lange, LA, Nalls, MA, Okut, H, Tajuddin, SM, Tayo, BO, Vedantam, S, Bradfield, JP, Chen, G, Chen, WM, Chesi, A, Irvin, MR, Padhukasahasram, B, Smith, JA, Zheng, W, Allison, MA, Ambrosone, CB, Bandera, EV, Bartz, TM, Berndt, SI, Bernstein, L, Blot, WJ, Bottinger, EP, Carpten, J, Chanock, SJ, Chen, YDI, Conti, DV, Cooper, RS, Fornage, M, Freedman, BI, Garcia, M, Goodman, PJ, Hsu, YHH, Hu, J, Huff, CD, Ingles, SA, John, EM, Kittles, R, Klein, E, Li, J, McKnight, B, Nayak, U, Nemesure, B, Ogunniyi, A, Olshan, A, Press, MF, Rohde, R, Rybicki, BA, Salako, B, Sanderson, M, Shao, Y, Siscovick, DS, Stanford, JL, Stevens, VL, Stram, A, Strom, SS, Vaidya, D, Witte, JS, Yao, J, Zhu, X, Ziegler, RG, Zonderman, AB, Adeyemo, A, Ambs, S, Cushman, M, Faul, JD, Hakonarson, H, Levin, AM, Nathanson, KL, Ware, EB
Publikováno v:
Ng, MCY; Graff, M; Lu, Y; Justice, AE; Mudgal, P; Liu, CT; et al.(2017). Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African ancestry anthropometry genetics consortium. PLoS Genetics, 13(4). doi: 10.1371/journal.pgen.1006719. UCLA: Retrieved from: http://www.escholarship.org/uc/item/72z6n71t
© 2017 Public Library of Science. All rights reserved. Genome-wide association studies (GWAS) have identified >300 loci associated with measures of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted for BMI, WHRadjBMI), but f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::bc3d2b4e46993735242222e530813c52
http://www.escholarship.org/uc/item/72z6n71t
http://www.escholarship.org/uc/item/72z6n71t
Autor:
Gusev, A, Shi, H, Kichaev, G, Pomerantz, M, Li, F, Long, HW, Ingles, SA, Kittles, RA, Strom, SS, Rybicki, BA, Nemesure, B, Isaacs, WB, Zheng, W, Pettaway, CA, Yeboah, ED, Tettey, Y, Biritwum, RB, Adjei, AA, Tay, E, Truelove, A, Niwa, S, Chokkalingam, AP, John, EM, Murphy, AB, Signorello, LB, Carpten, J, Leske, MC, Wu, S-Y, Hennis, AJM, Neslund-Dudas, C, Hsing, AW, Chu, L, Goodman, PJ, Klein, EA, Witte, JS, Casey, G, Kaggwa, S, Cook, MB, Stram, DO, Blot, WJ, Eeles, RA, Easton, D, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Southey, MC, Fitzgerald, LM, Gronberg, H, Wiklund, F, Aly, M, Henderson, BE, Schleutker, J, Wahlfors, T, Tammela, TLJ, Nordestgaard, BG, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharoah, P, Pashayan, N, Khaw, K-T, Stanford, JL, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Wokolorczyk, D, Kluzniak, W, Cannon-Albright, L, Teerlink, C, Brenner, H, Dieffenbach, AK, Arndt, V, Park, JY, Sellers, TA, Lin, H-Y, Slavov, C, Kaneva, R, Mitev, V, Batra, J, Spurdle, A, Clements, JA, Teixeira, MR, Pandha, H, Michael, A, Paulo, P, Maia, S, Kierzek, A, Conti, DV, Albanes, D, Berg, C, Berndt, SI, Campa, D, Crawford, ED, Diver, WR, Gapstur, SM, Gaziano, JM, Giovannucci, E, Hoover, R, Hunter, DJ, Johansson, M, Kraft, P, Le Marchand, L, Lindstrom, S, Navarro, C, Overvad, K, Riboli, E, Siddiq, A, Stevens, VL, Trichopoulos, D, Vineis, P, Yeager, M, Trynka, G, Raychaudhuri, S, Schumacher, FR, Price, AL, Freedman, ML, Haiman, CA, Pasaniuc, B, Cook, M, Guy, M, Govindasami, K, Leongamornlert, D, Sawyer, EJ, Wilkinson, R, Saunders, EJ, Tymrakiewicz, M, Dadaev, T, Morgan, A, Fisher, C, Hazel, S, Livni, N, Lophatananon, A, Pedersen, J, Hopper, JL, Adolfson, J, Stattin, P, Johansson, J-E, Cavalli-Bjoerkman, C, Karlsson, A, Broms, M, Auvinen, A, Kujala, P, Maeaettaenen, L, Murtola, T, Taari, K, Weischer, M, Nielsen, SF, Klarskov, P, Roder, A, Iversen, P, Wallinder, H, Gustafsson, S, Cox, A, Brown, P, George, A, Marsden, G, Lane, A, Davis, M, Tillmans, L, Riska, S, Wang, L, Rinckleb, A, Lubiski, J, Stegmaier, C, Pow-Sang, J, Park, H, Radlein, S, Rincon, M, Haley, J, Zachariah, B, Kachakova, D, Popov, E, Mitkova, A, Vlahova, A, Dikov, T, Christova, S, Heathcote, P, Wood, G, Malone, G, Saunders, P, Eckert, A, Yeadon, T, Kerr, K, Collins, A, Turner, M, Srinivasan, S, Kedda, M-A, Alexander, K, Omara, T, Wu, H, Henrique, R, Pinto, P, Santos, J, Barros-Silva, J, Consortium, PRACTICAL
Although genome-wide association studies have identified over 100 risk loci that explain ~33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::0fe693521eaa3b35bf6a8503b8bf0cf5
https://eprints.whiterose.ac.uk/101528/1/ncomms10979.pdf
https://eprints.whiterose.ac.uk/101528/1/ncomms10979.pdf
Autor:
Berndt, Si, Wang, Z, Yeager, M, Alavanja, Mc, Albanes, D, Amundadottir, L, Andriole, G, Beane Freeman, L, Campa, D, Cancel-Tassin, G, Canzian, F, Cornu, Jn, Cussenot, O, Diver, Wr, Gapstur, Sm, Grönberg, H, Haiman, Ca, Henderson, B, Hutchinson, A, Hunter, Dj, Key, Tj, Kolb, S, Koutros, S, Kraft, P, Le Marchand, L, Lindström, S, Machiela, Mj, Ostrander, Ea, Riboli, E, Schumacher, F, Siddiq, A, Stanford, Jl, Stevens, Vl, Travis, Rc, Tsilidis, Kk, Virtamo, J, Weinstein, S, Wilkund, F, Xu, J, Lilly Zheng, S, Yu, K, Wheeler, W, Zhang, H, African, Ancestry Prostate Cancer GWAS Consortium, Sampson, J, Black, A, Jacobs, K, Hoover, Rn, Tucker, M, Chanock, Sj. Ingles SA, Kittles, Ra, Strom, Ss, Rybicki, Ba, Nemesure, B, Isaacs, Wb, Zheng, W, Pettaway, Ca, Yeboah, Ed, Tettey, Y, Biritwum, Rb, Adjei, Aa, Tay, E, Truelove, A, Niwa, S, Chokkalingam, Ap, John, Em, Murphy, Ab, Signorello, Lb, Carpten, J, Leske, Mc, Wu, Sy, Hennis, Aj, Neslund-Dudas, C, Hsing, Aw, Chu, L, Goodman, Pj, Klein, Ea, Witte, Js, Casey, G, Kaggwa, S, Cook, Mb, Stram, Do, Blot, Wj.
Publikováno v:
Nature communications, vol 6, iss 1
Nature communications
Nature communications
Most men diagnosed with prostate cancer will experience indolent disease; hence, discovering genetic variants that distinguish aggressive from nonaggressive prostate cancer is of critical clinical importance for disease prevention and treatment. In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b20cea69551265965da8af6a71b23a
http://hdl.handle.net/10044/1/28168
http://hdl.handle.net/10044/1/28168
Autor:
O’dushlaine, C, Rossin, L, Lee, PH, Duncan, L, Parikshak, NN, Newhouse, S, Ripke, S, Neale, BM, Purcell, SM, Posthuma, D, Nurnberger, JI, Lee, SH, Faraone, SV, Perlis, RH, Mowry, BJ, Thapar, A, Goddard, ME, Witte, JS, Absher, D, Agartz, I, Akil, H, Amin, F, Andreassen, OA, Anjorin, A, Anney, R, Anttila, V, Arking, DE, Asherson, P, Azevedo, MH, Backlund, L, Badner, JA, Bailey, AJ, Banaschewski, T, Barchas, JD, Barnes, MR, Barrett, TB, Bass, N, Battaglia, A, Bauer, M, Bayés, M, Bellivier, F, Bergen, SE, Berrettini, W, Betancur, C, Bettecken, T, Biederman, J, Binder, EB, Black, DW, Blackwood, DHR, Bloss, CS, Boehnke, M, Boomsma, DI, Breuer, R, Bruggeman, R, Cormican, P, Buccola, NG, Buitelaar, JK, Bunney, WE, Buxbaum, JD, Byerley, WF, Byrne, EM, Caesar, S, Cahn, W, Cantor, RM, Casas, M, Chakravarti, A, Chambert, K, Choudhury, K, Cichon, S
Publikováno v:
O’dushlaine, C; Rossin, L; Lee, PH; Duncan, L; Parikshak, NN; Newhouse, S; et al.(2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience, 18(2), 199-209. doi: 10.1038/nn.3922. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7282p56w
© 2015 Nature America, Inc. All rights reserved. Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::22ddcc0e1fcac2fb84a584975818156d
http://www.escholarship.org/uc/item/7282p56w
http://www.escholarship.org/uc/item/7282p56w
Autor:
Witte, John, Weng, PH, Huang, YL, Page, JH, Chen, JH, Xu, J, Koutros, S, Berndt, S, Chanock, S, Yeager, M, Witte, JS
Publikováno v:
Witte, John; Weng, PH; Huang, YL; Page, JH; Chen, JH; Xu, J; et al.(2014). Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: A systematic review and meta-analysis. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/61z828tq
© 2014 Weng et al.Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::725e33f8a84080b38d3656bf85654203
http://www.escholarship.org/uc/item/61z828tq
http://www.escholarship.org/uc/item/61z828tq
Autor:
Chhibber, A, Mefford, J, Stahl, EA, Pendergrass, SA, Baldwin, RM, Owzar, K, Li, M, Winer, EP, Hudis, CA, Zembutsu, H, Kubo, M, Nakamura, Y, McLeod, HL, Ratain, MJ, Shulman, LN, Ritchie, MD, Plenge, RM, Witte, JS, Kroetz, DL
Publikováno v:
Pharmacogenomics Journal, vol 14, iss 4
Peripheral neuropathy is a common dose-limiting toxicity for patients treated with paclitaxel. For most individuals, there are no known risk factors that predispose patients to the adverse event, and pathogenesis for paclitaxel-induced peripheral neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e70e960aba4b968132671fec06d80631
https://escholarship.org/uc/item/53n789q6
https://escholarship.org/uc/item/53n789q6
Autor:
Witte, John, Mosley, JD, Van, SL, Larkin, EK, Weeke, PE, Witte, JS, Wells, QS, Karnes, JH, Guo, Y, Bastarache, L, Olson, LM
Publikováno v:
Witte, John; Mosley, JD; Van, SL; Larkin, EK; Weeke, PE; Witte, JS; et al.(2013). Mechanistic phenotypes: An aggregative phenotyping strategy to identify disease mechanisms using GWAS data. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8vn7w2hf
A single mutation can alter cellular and global homeostatic mechanisms and give rise to multiple clinical diseases. We hypothesized that these disease mechanisms could be identified using low minor allele frequency (MAF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::f0237cacc359daa3e7121a3b7713c036
http://www.escholarship.org/uc/item/8vn7w2hf
http://www.escholarship.org/uc/item/8vn7w2hf
Autor:
Giacomini, Kathleen, Witte, John, Andreadis, Charalambos, Yee, SW, Mefford, JA, Singh, N, Percival, ME, Stecula, A, Yang, K, Witte, JS, Takahashi, A, Kubo, M, Matsuda, K
Publikováno v:
Giacomini, Kathleen; Witte, John; Andreadis, Charalambos; Yee, SW; Mefford, JA; Singh, N; et al.(2013). Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/9pj4g64h
Acute myeloid leukemia (AML) is a clinically heterogeneous disease, with a 5-year disease-free survival (DFS) ranging from under 10% to over 70% for distinct groups of patients. At our institution, cytarabine, etoposide and busulfan are used in first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::fe82358d0fe1b517a9ca460ec77e71bb
http://www.escholarship.org/uc/item/9pj4g64h
http://www.escholarship.org/uc/item/9pj4g64h