Targeting the Plasmodium falciparum IspE Enzyme.

Autor: Diamanti E; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Saarland University, Department of Pharmacy, Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany., Steinbach AM; Center for Protein Assemblies, Technical University of Munich, Ernst-Otto-Fischer-Straße 8, 85748 Garching, Germany., de Carvalho LP; Institute of Tropical Medicine, University of Tübingen, Wilhelmstraße 27, 72074 Tübingen, Germany., Ropponen HK; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Saarland University, Department of Pharmacy, Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus Building E8.1, 66123 Saarbrücken, Germany., Lacour A; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Saarland University, Department of Pharmacy, Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus Building E8.1, 66123 Saarbrücken, Germany., Hamid R; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Saarland University, Department of Pharmacy, Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus Building E8.1, 66123 Saarbrücken, Germany., Eisa S; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Saarland University, Department of Pharmacy, Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus Building E8.1, 66123 Saarbrücken, Germany., Bravo P; Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland.; Universität Basel Petersplatz 1, 4003 Basel, Switzerland., Bousis S; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Saarland University, Department of Pharmacy, Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany., Illarionov B; Hamburg School of Food Science, Institute of Food Chemistry, Grindelallee 117, 20146 Hamburg, Germany., Fischer M; Hamburg School of Food Science, Institute of Food Chemistry, Grindelallee 117, 20146 Hamburg, Germany., Hamed MM; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Saarland University, Department of Pharmacy, Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany., Bach NC; Center for Protein Assemblies, Technical University of Munich, Ernst-Otto-Fischer-Straße 8, 85748 Garching, Germany., Rottmann M; Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland.; Universität Basel Petersplatz 1, 4003 Basel, Switzerland., Held J; Institute of Tropical Medicine, University of Tübingen, Wilhelmstraße 27, 72074 Tübingen, Germany.; German Centre for Infection Research (DZIF), 38124 Braunschweig, Germany., Witschel M; BASF-SE Carl-Bosch-Strasse 38, 67056 Ludwigshafen, Germany., Sieber SA; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Saarland University, Department of Pharmacy, Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.; Center for Protein Assemblies, Technical University of Munich, Ernst-Otto-Fischer-Straße 8, 85748 Garching, Germany., Hirsch AKH; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Saarland University, Department of Pharmacy, Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany.; Saarland University, Campus Building E8.1, 66123 Saarbrücken, Germany.

Publikováno v: ACS omega [ACS Omega] 2024 Oct 25; Vol. 9 (44), pp. 44465-44473. Date of Electronic Publication: 2024 Oct 25 (Print Publication: 2024).

Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors.

Autor: Lettl C; Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Pettenkoferstrasse 9a, 80336 Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany., Schindele F; Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Pettenkoferstrasse 9a, 80336 Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany., Mehdipour AR; Center for Molecular Modeling, Ghent University, 9052 Zwijnaarde, Belgium; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany., Steiner T; Bavarian NMR Center-Structural Membrane Biochemistry, Department of Chemistry, Technical University Munich, 85748 Garching, Germany., Ring D; Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Pettenkoferstrasse 9a, 80336 Munich, Germany., Brack-Werner R; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany; German Research Center for Environmental Health, Institute of Virology, Helmholtz Center Munich, 85764 Neuherberg, Germany., Stecher B; Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Pettenkoferstrasse 9a, 80336 Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany., Eisenreich W; Bavarian NMR Center-Structural Membrane Biochemistry, Department of Chemistry, Technical University Munich, 85748 Garching, Germany., Bilitewski U; Helmholtz Center for Infection Research, 38124 Braunschweig, Germany; German Center for Infection Research (DZIF), Partner Site Hannover/Braunschweig, Braunschweig, Germany., Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany; Institute for Biophysics, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany., Witschel M; BASF SE, 67056 Ludwigshafen, Germany., Fischer W; Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Pettenkoferstrasse 9a, 80336 Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. Electronic address: fischer@mvp.lmu.de., Haas R; Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Pettenkoferstrasse 9a, 80336 Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. Electronic address: haas@mvp.lmu.de.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2023 May 18; Vol. 30 (5), pp. 499-512.e5. Date of Electronic Publication: 2023 Apr 25.

Agrochemical Lessons for Infectious Disease Research: New Resistance Breaking Antifungal Hits against Candida auris .

Autor: Winter C; BASF-SE, D-67056 Ludwigshafen, Germany., Siepe I; BASF-SE, D-67117 Limburgerhof, Germany., Wise A; Evotec, Alderley Park, Cheshire SK10 4TG, U.K., Dorali A; Evotec, Alderley Park, Cheshire SK10 4TG, U.K., Barrett AGM; Department of Chemistry, Imperial College London, London W12 0BZ, U.K., Witschel M; BASF-SE, D-67056 Ludwigshafen, Germany.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Jan 25; Vol. 14 (2), pp. 136-140. Date of Electronic Publication: 2023 Jan 25 (Print Publication: 2023).

Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class.

Autor: Diamanti E; Helmholtz Institute for Pharmaceutical Research (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University Campus E8.1, 66123, Saarbrücken, Germany.; Helmholtz International Lab for Anti-Infectives, Saarland University Campus E8.1, 66123, Saarbrücken, Germany., Hamed MM; Helmholtz Institute for Pharmaceutical Research (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University Campus E8.1, 66123, Saarbrücken, Germany., Lacour A; Helmholtz Institute for Pharmaceutical Research (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University Campus E8.1, 66123, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Campus E8.1, 66123, Saarbrücken, Germany., Bravo P; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002, Basel, Switzerland.; Universität Basel, Petersplatz 1, 4003, Basel, Switzerland., Illarionov B; Hamburg School of Food Science, University of Hamburg, Grindelallee 117, 20146, Hamburg, Germany., Fischer M; Hamburg School of Food Science, University of Hamburg, Grindelallee 117, 20146, Hamburg, Germany., Rottmann M; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002, Basel, Switzerland.; Universität Basel, Petersplatz 1, 4003, Basel, Switzerland., Witschel M; BASF-SE, Carl-Bosch-Strasse 38, 67056, Ludwigshafen, Germany., Hirsch AKH; Helmholtz Institute for Pharmaceutical Research (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University Campus E8.1, 66123, Saarbrücken, Germany.; Helmholtz International Lab for Anti-Infectives, Saarland University Campus E8.1, 66123, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Campus E8.1, 66123, Saarbrücken, Germany.

Publikováno v: ChemMedChem [ChemMedChem] 2022 Mar 04; Vol. 17 (5), pp. e202100679. Date of Electronic Publication: 2022 Jan 11.

Sulfur‐based functional groups in agrochemistry.

Autor: Jeanguenat, Andre, Lamberth, Clemens

Publikováno v: Pest Management Science; Aug2023, Vol. 79 Issue 8, p2647-2663, 17p