Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Witold Dyrka"'
Autor:
Jakub W Wojciechowski, Emirhan Tekoglu, Marlena Gąsior-Głogowska, Virginie Coustou, Natalia Szulc, Monika Szefczyk, Marta Kopaczyńska, Sven J Saupe, Witold Dyrka
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010787 (2022)
NLR proteins are intracellular receptors constituting a conserved component of the innate immune system of cellular organisms. In fungi, NLRs are characterized by high diversity of architectures and presence of amyloid signaling. Here, we explore the
Externí odkaz:
https://doaj.org/article/20da7749729543e6904b2828fb499ec3
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-28 (2021)
Abstract Background Amyloid signaling motifs are a class of protein motifs which share basic structural and functional features despite the lack of clear sequence homology. They are hard to detect in large sequence databases either with the alignment
Externí odkaz:
https://doaj.org/article/33c32c085f2247e985828bae00fc12ab
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-6 (2017)
Abstract Background The field of protein sequence analysis is dominated by tools rooted in substitution matrices and alignments. A complementary approach is provided by methods of quantitative characterization. A major advantage of the approach is th
Externí odkaz:
https://doaj.org/article/28deb87f318d41669d3292eb7338e004
Publikováno v:
PeerJ, Vol 7, p e6559 (2019)
Interactions between amino acids that are close in the spatial structure, but not necessarily in the sequence, play important structural and functional roles in proteins. These non-local interactions ought to be taken into account when modeling colle
Externí odkaz:
https://doaj.org/article/1ac67adb44c44f179ef3183215d20eae
Autor:
Jakub W. Wojciechowski, Emirhan Tekoglu, Marlena Gąsior-Głogowska, Virginie Coustou, Natalia Szulc, Monika Szefczyk, Marta Kopaczyńska, Sven J. Saupe, Witold Dyrka
NLR proteins are intracellular receptors constituting a conserved component of the innate immune system of multicellular organisms. In fungi, NLRs are characterized by high diversity of architectures and presence of amyloid signaling. Here, we explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4bb01dbfd4bde1c7013f7735e7ee78
https://doi.org/10.1101/2022.03.16.484565
https://doi.org/10.1101/2022.03.16.484565
Autor:
Corinne Clavé, Witold Dyrka, Elizabeth A. Turcotte, Alexandra Granger-Farbos, Léa Ibarlosa, Benoît Pinson, Russell E. Vance, Sven J. Saupe, Asen Daskalov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(7)
Significance The recent discovery of gasdermin-like proteins in fungi have brought to light that this family of pore-forming proteins controls cell death in two of the major eukaryotic kingdoms, fungi and mammals. Yet the regulation of cytotoxicity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac1dd04fdda8e558c2a206d9adb1c00
https://pubmed.ncbi.nlm.nih.gov/35235459
https://pubmed.ncbi.nlm.nih.gov/35235459
Autor:
Corinne Clavé, Witold Dyrka, Pinson B, Alexandra Granger-Farbos, Asen Daskalov, Sven J. Saupe
Gasdermins are a family of pore-forming proteins controlling an inflammatory cell death reaction in the mammalian immune system. The pore-forming ability of the gasdermin proteins is released by proteolytic cleavage with the removal of their inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eeb28f7f2a573125ce1e6a2dadadd28
https://doi.org/10.1101/2021.06.03.446900
https://doi.org/10.1101/2021.06.03.446900
BackgroundAmyloid signaling motifs are a class of protein motifs which share basic structural and functional features despite lack of apparent sequence homology. They are hard to detect in large sequence databases either with the alignment-based prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df4c996a8f7f931b60334bfd3bb0a748
https://doi.org/10.1101/2021.01.22.426858
https://doi.org/10.1101/2021.01.22.426858
Autor:
Mélanie Berbon, Antoine Loquet, Witold Dyrka, Thierry Bardin, Alons Lends, Sven J. Saupe, Bénédicte Salin, Corinne Blancard, Brice Kauffmann, Virginie Coustou, Asen Daskalov
Publikováno v:
Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2020, 432, pp.6005-6027. ⟨10.1016/j.jmb.2020.10.004⟩
Journal of Molecular Biology, 2020, 432, pp.6005-6027. ⟨10.1016/j.jmb.2020.10.004⟩
Journal of Molecular Biology, Elsevier, 2020, 432, pp.6005-6027. ⟨10.1016/j.jmb.2020.10.004⟩
Journal of Molecular Biology, 2020, 432, pp.6005-6027. ⟨10.1016/j.jmb.2020.10.004⟩
International audience; In filamentous fungi, amyloid signaling sequences allow Nod-like receptors (NLRs) to activate downstream cell-death inducing proteins with HeLo and HeLo-like (HELL) domains and amyloid RHIM and RHIM-related motifs control immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5ca9f9a7cd48b8e1fc9611c8a4660f
https://hal.archives-ouvertes.fr/hal-02989877/document
https://hal.archives-ouvertes.fr/hal-02989877/document
Autor:
Asen Daskalov, Thierry Bardin, Virginie Coustou, Brice Kauffmann, Antoine Loquet, Bénédicte Salin, Witold Dyrka, Corinne Blancard, Mélanie Berbon, Alons Lends, Sven J. Saupe
NLRs (Nod-like receptors) are intracellular receptors regulating immunity, symbiosis, non-self recognition and programmed cell death in animals, plants and fungi. Several fungal NLRs employ amyloid signaling motifs to activate downstream cell-death i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cabefa53482d4f68f7d957d8ba21487