Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Witold Cieplak"'
Autor:
Brenna Kelley-Clarke, Ozan S. Kumru, David B. Volkin, Witold Cieplak, Sangeeta B. Joshi, C. Wayne R. Gombotz, Yu Wang, Tae Kim
Publikováno v:
Journal of Pharmaceutical Sciences. 107:2764-2774
A replication-deficient lentiviral vector encoding the tumor antigen gene NY-ESO-1 was characterized in terms of vector morphology, particle size range, concentration, and zeta potential using a variety of physical methods. Environmentally stressed v
Autor:
Witold Cieplak, Brian Long, Terri Wrin, Barbara Sloan, Jose M. Rivera, Sofiya A. Galkina, Ukina R. Sanford, Mary E. Moreno, Po-Ying Chan-Hui, Pheroze Joshi, Ekaterina Maidji, Cheryl A. Stoddart, Galina Kosikova
Publikováno v:
Virology, vol 462-463, iss 1
Highly potent broadly neutralizing human monoclonal antibodies hold promise for HIV prophylaxis and treatment. We used the SCID-hu Thy/Liv and BLT humanized mouse models to study the efficacy of these antibodies, primarily PG16, against HIV-1 clades
Autor:
Yoshihiro Kawaoka, Masato Hatta, Andres G. Grandea, Jennifer L. Mitcham, Philip Hammond, Witold Cieplak, Maki Kiso, Ole A. Olsen, Mark A. Renshaw, Matthew Moyle, Kyoko Shinya, Shaun M. Stewart, Thomas C. Cox, Andrew Pekosz, Po-Ying Chan-Hui, Michael L. Grantham
Publikováno v:
Proceedings of the National Academy of Sciences. 107:12658-12663
Influenza remains a serious public health threat throughout the world. Vaccines and antivirals are available that can provide protection from infection. However, new viral strains emerge continuously because of the plasticity of the influenza genome,
Publikováno v:
Journal of Biological Chemistry. 275:13465-13475
The stoichiometry of the binding of GTP to ADP-ribosylation factor (ARF) proteins, normally quite low at approximately 0.05 mol/mol protein, was found to increase to a maximum of 1 mol/mol in the presence of effectors. The mechanism of this action wa
Publikováno v:
Biochemistry. 40(15)
Cholera toxin (CT) and the heat-labile enterotoxin (LT) from Escherichia coli are highly related in terms of structure and biochemical activities and are the causative agents of cholera and traveler's diarrhea, respectively. The pathophysiological ac
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 164(10)
A conformationally biased decapeptide agonist of human C5a anaphylatoxin (YSFKPMPLaR) was used as a molecular adjuvant in stimulating an Ag-specific CTL response against murine P815S target cells expressing an Ld-restricted CTL epitope of the hepatit
Autor:
Andres Grandea, Ole Olsen, Tom Cox, Mark Renshaw, Philip Hammond, Po-Ying Chan-Hui, Jennifer Mitcham, Witold Cieplak, Shaun Stewart, Michael Grantham, Andrew Pekosz, Masato Hatta, Yoshihiro Kawaoka, Matthew Moyle
Publikováno v:
The Journal of Immunology. 184:38.14-38.14
Specific antibody responses to the annual influenza vaccine can protect against infection if the vaccine and the infective strain are antigenically well-matched. However, due to the variability of the influenza genome, emergent strains arise for whic
Autor:
Ole Olsen, Steve Frey, Christy Boozer, Glen Grandea, Mike Cicarelli, Rebecca Lily, Courtney Ward, Alison Fitch, I-wei Feng, David Jellyman, Roxanne Grondin, Aaron Gibbs, Po-ying Chan-hui, Darbie Whitman, Ray Fox, Bruce Mosley, Phil Hammond, Mark Branum, Witold Cieplak, Matthew Moyle
Publikováno v:
The Journal of Immunology. 184:38.12-38.12
Influenza A continues to be a serious public health threat as it continuously evolves to evade and escape immune surveillance through genetic drift, shift, and re-assortment. Hemagglutinin (HA) is the main glycoprotein target of the humoral immune re
Autor:
Po-Ying Chan-hui, Tom Cox, Roxanne Grondin, Glen Grandea, Steve Frey, Mark Branum, Courtney Ward, Ray Fox, Ole Olsen, Phil Hammond, Witold Cieplak, Matthew Moyle
Publikováno v:
The Journal of Immunology. 184:96.24-96.24
Background. GM-CSF has been implicated in the development of autoimmune disorders. The efficacy of neutralizing anti-GM-CSF has been demonstrated in several animal disease models rheumatoid arthritis, asthma and lung inflammation. While humanization