Výsledky vyhledávání - "Witold, Więcek"

Clinical trials for accelerating pandemic vaccines

Autor: Witold Więcek

Publikováno v: Oxford Review of Economic Policy. 38:797-817

We provide a short overview of clinical trials of vaccines, with particular focus on (i) adaptive and platform trials, (ii) human challenge trials, and (iii) vaccine use optimization, especially fractional dosing. We describe their relationship with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8966b7d47e86908026f15c99b5860c5c
https://doi.org/10.1093/oxrep/grac029

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Assessing the Combined Public Health Impact of Pharmaceutical Interventions on Pandemic Transmission and Mortality: An Example in SARS CoV ‐2

Autor: Mohamed A, Kamal, Andreas, Kuznik, Luyuan, Qi, Witold, Więcek, Mohamed, Hussein, Hazem E, Hassan, Kashyap, Patel, Thomas, Obadia, Masood Khaksar, Toroghi, Daniela J, Conrado, Nidal, Al-Huniti, Roman, Casciano, Meagan P, O'Brien, Ruanne V, Barnabas, Myron S, Cohen, Patrick F, Smith

Publikováno v: Clinical Pharmacology & Therapeutics. 112:1224-1235

To assess the combined role of anti-viral monoclonal antibodies (mAbs) and vaccines in reducing severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) transmission and mortality in the United States, an agent-based model was developed that acco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326171910bbd94d4e905c21765f17a37
https://doi.org/10.1002/cpt.2728

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A systematic review of human challenge trials, designs, and safety

Autor: Jupiter Adams-Phipps, Danny Toomey, Witold Więcek, Virginia Schmit, James Wilkinson, Keller Scholl, Euzebiusz Jamrozik, Joshua Osowicki, Meta Roestenberg, David Manheim

Publikováno v: Clinical Infectious Diseases, 76(4), 609-619. OXFORD UNIV PRESS INC

BackgroundFew studies have assessed participant safety in human challenge trials (HCTs). Key questions regarding HCTs include how risky such trials have been, how often adverse events (AEs) and serious adverse events (SAEs) occur, and whether risk mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f4b7e181ebca8bcc1170c533eb1b62
https://hdl.handle.net/1887/3491506

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Testing fractional doses of COVID-19 vaccines

Autor: Witold Więcek, Amrita Ahuja, Esha Chaudhuri, Michael Kremer, Alexandre Simoes Gomes, Christopher M. Snyder, Alex Tabarrok, Brandon Joel Tan

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(8)

Due to the enormous economic, health, and social costs of the COVID-19 pandemic, there are high expected social returns to investing in parallel in multiple approaches to accelerating vaccination. We argue there are high expected social returns to in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651f80858e085ba25985da9d7eabba9f
https://pubmed.ncbi.nlm.nih.gov/35131899

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Transcriptomic mapping of the inter-individual variability of cellular stress response activation in primary human hepatocytes

Autor: Lysiane Richert, Suzanna Huppelschoten, Bob van de Water, Marije Niemeijer, Frédéric Y. Bois, Witold Więcek, Richard S. Paules, Audrey Baze, Céline Parmentier, Peter Bouwman

Background & AimsOne of the early key events of drug-induced liver injury (DILI) is the activation of adaptive stress responses, a cellular mechanism to overcome stress. Given the diversity of DILI outcomes and lack in understanding of population var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fda617ff83e9f8251089a5361331f387
https://doi.org/10.1101/2021.08.26.457742

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Testing Fractional doses of COVID-19 Vaccines

Autor: Witold Więcek, Alexander Tabarrok, Amrita Ahuja, Alexandre Simoes Gomes, Christopher M. Snyder, Michael Kremer, Brandon Joel Tan, Esha Chaudhuri

Millions of people are being vaccinated against SARS-CoV-2 every day, but the virus is also mutating and spreading fast. Vaccine production is increasing, but supply still constrains vaccinations worldwide. Using lower doses of vaccines could dramati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::198d59d081eccb9e0b1e43ec1558e1fd
https://doi.org/10.3386/w29180

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Could Vaccine Dose Stretching Reduce COVID-19 Deaths?

Autor: Christopher M. Snyder, Brandon Joel Tan, Amrita Ahuja, Alexander Tabarrok, Alexandre Simoes Gomes, Michael Kremer, Witold Więcek

We argue that alternative COVID-19 vaccine dosing regimens could potentially dramatically accelerate global COVID-19 vaccination and reduce mortality, and that the costs of testing these regimens are dwarfed by their potential benefits. We first use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91db709255869f3a6192eab5a5bacb9a
https://doi.org/10.3386/w29018

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