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Size-exclusion chromatography as a multi-attribute method for process and product characterization of adeno-associated virus.

Autor: Mulagapati SHR; Process and Analytical Sciences, BioPharmaceuticals Development (BPD), R&D, AstraZeneca, Gaithersburg, MD, USA., Parupudi A; Drug Product and Formulation Sciences, GSK Vaccines, Rockville, MD 20850, USA., Witkos T; Process and Analytical Sciences, BioPharmaceuticals Development (BPD), R&D, AstraZeneca, Gaithersburg, MD, USA., Bond N; Process and Analytical Sciences, BioPharmaceuticals Development (BPD), R&D, AstraZeneca, Gaithersburg, MD, USA., Chen X; Process and Analytical Sciences, BioPharmaceuticals Development (BPD), R&D, AstraZeneca, Gaithersburg, MD, USA., Linke T; Process and Analytical Sciences, BioPharmaceuticals Development (BPD), R&D, AstraZeneca, Gaithersburg, MD, USA., Xi G; Process and Analytical Sciences, BioPharmaceuticals Development (BPD), R&D, AstraZeneca, Gaithersburg, MD, USA., Schmelzer AE; Viral Vector Product Development, Process Development and Clinical Supply, Alexion, Boston, MA, USA., Xu W; Process and Analytical Sciences, BioPharmaceuticals Development (BPD), R&D, AstraZeneca, Gaithersburg, MD, USA.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2024 Nov 19; Vol. 32 (4), pp. 101382. Date of Electronic Publication: 2024 Nov 19 (Print Publication: 2024).

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.

Autor: Chan WL; Institut für Medizinische Genetik und Humangenetik, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; FG Development & Disease, Max-Planck-Institut fuer Molekulare Genetik, Berlin, Germany.; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam Road, Hong Kong., Steiner M; Institut für Medizinische Genetik und Humangenetik, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; Berlin School for Regenerative Therapies (BSRT), Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Witkos T; School of Biology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom., Egerer J; Institut für Medizinische Genetik und Humangenetik, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Busse B; Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mizumoto S; Lab. of Proteoglycan Signaling and Therapeutics, Faculty of Advanced Life Science, Graduate School of Life Science, Hokkaido University, Sapporo, Japan., Pestka JM; Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zhang H; Institut für Medizinische Genetik und Humangenetik, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Hausser I; Institute of Pathology, University Clinic Heidelberg, Heidelberg, Germany., Khayal LA; Institut für Medizinische Genetik und Humangenetik, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Ott CE; Institut für Medizinische Genetik und Humangenetik, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Kolanczyk M; FG Development & Disease, Max-Planck-Institut fuer Molekulare Genetik, Berlin, Germany., Willie B; Julius Wolff Institute, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Schinke T; Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Paganini C; Department of Molecular Medicine, Unit of Biochemistry, University of Pavia, Pavia, Italy., Rossi A; Department of Molecular Medicine, Unit of Biochemistry, University of Pavia, Pavia, Italy., Sugahara K; Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Amling M; Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Knaus P; Institute for Chemistry and Biochemistry, Freie Universität, Berlin, Germany., Chan D; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam Road, Hong Kong.; The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU- SIRI), Hi-Tech Industrial Park, Nanshan, Shenzhen, China., Lowe M; School of Biology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom., Mundlos S; Institut für Medizinische Genetik und Humangenetik, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; FG Development & Disease, Max-Planck-Institut fuer Molekulare Genetik, Berlin, Germany.; Berlin-Brandenburg Center for Regenerative Therapies, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Kornak U; Institut für Medizinische Genetik und Humangenetik, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; FG Development & Disease, Max-Planck-Institut fuer Molekulare Genetik, Berlin, Germany.; Berlin-Brandenburg Center for Regenerative Therapies, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Publikováno v: PLoS genetics [PLoS Genet] 2018 Mar 21; Vol. 14 (3), pp. e1007242. Date of Electronic Publication: 2018 Mar 21 (Print Publication: 2018).