Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power.

Autor: Hobbs KF; Biochemistry and Molecular Biology Department, University of Iowa, 51 Newton Road, 4-403 Bowen Science Building, Iowa City, IA, 52242, USA., Propp J; Pharmaceutics and Experimental Therapeutics Department, Medicinal and Natural Products Chemistry Division, University of Iowa, 180 South Grand Avenue, Iowa City, IA, 52242, USA., Vance NR; Pharmaceutics and Experimental Therapeutics Department, Medicinal and Natural Products Chemistry Division, University of Iowa, 180 South Grand Avenue, Iowa City, IA, 52242, USA., Kalenkiewicz A; Biochemistry and Molecular Biology Department, University of Iowa, 51 Newton Road, 4-403 Bowen Science Building, Iowa City, IA, 52242, USA., Witkin KR; Pharmaceutics and Experimental Therapeutics Department, Medicinal and Natural Products Chemistry Division, University of Iowa, 180 South Grand Avenue, Iowa City, IA, 52242, USA., Ashley Spies M; Biochemistry and Molecular Biology Department, University of Iowa, 51 Newton Road, 4-403 Bowen Science Building, Iowa City, IA, 52242, USA.; Pharmaceutics and Experimental Therapeutics Department, Medicinal and Natural Products Chemistry Division, University of Iowa, 180 South Grand Avenue, Iowa City, IA, 52242, USA.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Jul 14; Vol. 29 (40), pp. e202300872. Date of Electronic Publication: 2023 May 19.

An Atomistic Understanding of Allosteric Inhibition of Glutamate Racemase: a Dampening of Native Activation Dynamics.

Autor: Witkin KR; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutics and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52246, USA., Vance NR; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutics and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52246, USA., Caldwell C; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52246, USA., Li Q; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52246, USA., Yu L; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52246, USA.; NMR Core Facility, Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52246, USA., Spies MA; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutics and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52246, USA.; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52246, USA.

Publikováno v: ChemMedChem [ChemMedChem] 2020 Feb 17; Vol. 15 (4), pp. 376-384. Date of Electronic Publication: 2020 Jan 21.