Výsledky vyhledávání - "Witkiewicz, Agnieszka"

Akademický článek

Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer

Autor: Witkiewicz, Agnieszka K., Chung, Sejin, Brough, Rachel, Vail, Paris, Franco, Jorge, Lord, Christopher J., Knudsen, Erik S.

Approximately 30% of triple-negative breast cancers (TNBCs) exhibit functional loss of the RB tumor suppressor, suggesting a target for precision intervention. Here, we use drug screens to identify agents specifically antagonized by the retinoblastom

Externí odkaz: http://hdl.handle.net/10150/627049
http://arizona.openrepository.com/arizona/handle/10150/627049

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Akademický článek

Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature

Autor: Knudsen, Erik S., Hutcheson, Jack, Vail, Paris, Witkiewicz, Agnieszka K.

Recently developed potent and selective CDK4/6 inhibitors fall into two classes based on structure and toxicity profiles in clinical studies. One class, exemplified by palbociclib and ribociclib, exhibits neutropenia as a dose-limiting toxicity and r

Externí odkaz: http://hdl.handle.net/10150/625360
http://arizona.openrepository.com/arizona/handle/10150/625360

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Akademický článek

Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer.

Autor: Witkiewicz, Agnieszka K, Balaji, Uthra, Eslinger, Cody, McMillan, Elizabeth, Conway, William, Posner, Bruce, Mills, Gordon B, O'Reilly, Eileen M, Knudsen, Erik S

Pancreatic ductal adenocarcinoma (PDAC) harbors the worst prognosis of any common solid tumor, and multiple failed clinical trials indicate therapeutic recalcitrance. Here, we use exome sequencing of patient tumors and find multiple conserved genetic

Externí odkaz: http://hdl.handle.net/10150/621251
http://arizona.openrepository.com/arizona/handle/10150/621251

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Akademický článek

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential

Autor: Knudsen, Erik S., Balaji, Uthra, Freinkman, Elizaveta, McCue, Peter, Witkiewicz, Agnieszka K.

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. The aggressiveness and therapeutic recalcitrance of this malignancy has been attributed to multiple factors including the influence of an active desmoplastic stroma. How the stromal micr

Externí odkaz: http://hdl.handle.net/10150/622479
http://arizona.openrepository.com/arizona/handle/10150/622479

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Akademický článek

Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2- breast cancer

Autor: Knudsen, Erik S., Witkiewicz, Agnieszka K.

ER positive (ER+) and HER2 negative (HER2-) breast cancers are routinely treated based on estrogen dependence. CDK4/6 inhibitors in combination with endocrine therapy have significantly improved the progression-free survival of patients with ER+/HER2

Externí odkaz: http://hdl.handle.net/10150/622114
http://arizona.openrepository.com/arizona/handle/10150/622114

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