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Design of novel and potent cPLA2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap.

Autor: Mete A; Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, United Kingdom. Antonio.Mete@Astrazeneca.com, Andrews G, Bernstein M, Connolly S, Hartopp P, Jackson CG, Lewis R, Martin I, Murray D, Riley R, Robinson DH, Smith GM, Wells E, Withnall WJ

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 May 15; Vol. 21 (10), pp. 3128-33. Date of Electronic Publication: 2011 Mar 06.

Hydrogen bonded liquid crystalline heterodimers incorporating alkoxystilbazoles and alkoxy-4-pyridones.

Autor: Wolf, Jeremy R.¹ (AUTHOR) wolfj@abclabs.com, Dyer, Daniel J.¹ (AUTHOR)

Publikováno v: Liquid Crystals Today. Apr2015, Vol. 24 Issue 2, p47-55. 9p.

Structure–activity relationship studies of 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A 2 α-mediated arachidonic acid release in intact platelets: variation of the keto moiety.

Autor: Ghasemi, Afshin¹ (AUTHOR), Elfringhoff, Alwine Schulze¹ (AUTHOR), Lehr, Matthias¹ (AUTHOR) lehrm@uni-muenster.de

Publikováno v: Journal of Enzyme Inhibition & Medicinal Chemistry. Oct2005, Vol. 20 Issue 5, p429-437. 9p. 5 Diagrams, 2 Charts.

Inhibitors of cytosolic phospholipase Aα with carbamate structure: synthesis, biological activity, metabolic stability, and bioavailability.

Autor: Schwarzkopf, Julian, Sundermann, Tom, Arnsmann, Martina, Hanekamp, Walburga, Fabian, Jörg, Heidemann, Jan, Pott, Anna, Bettenworth, Dominik, Lehr, Matthias

Publikováno v: Medicinal Chemistry Research; Dec2014, Vol. 23 Issue 12, p5250-5262, 13p