Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Within-host diversity"'
Autor:
Jada Hackman, Elizabeth Miller, Jody Phelan, Carmen Sheppard, Ben Sobkowiak, William Jones-Warner, David Litt, Sonal Shah, Michiko Toizumi, Stefan Flasche, Norman K. Fry, Martin Hibberd, Lay-Myint Yoshida, Stéphane Hué
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: Inference on pneumococcal transmission has mostly relied on longitudinal studies which are costly and resource intensive. Therefore, we conducted a pilot study to test the ability to infer who infected whom from cross-sectional pneumococc
Externí odkaz:
https://doaj.org/article/c782992f7f31406c81377bb6c6c52c3f
Autor:
Arturo Torres Ortiz, Michelle Kendall, Nathaniel Storey, James Hatcher, Helen Dunn, Sunando Roy, Rachel Williams, Charlotte Williams, Richard A Goldstein, Xavier Didelot, Kathryn Harris, Judith Breuer, Louis Grandjean
Publikováno v:
eLife, Vol 12 (2023)
Accurate inference of who infected whom in an infectious disease outbreak is critical for the delivery of effective infection prevention and control. The increased resolution of pathogen whole-genome sequencing has significantly improved our ability
Externí odkaz:
https://doaj.org/article/5cf9eed94f9c44839b83b3606da1c956
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously evolving, bringing great challenges to the control of the virus. In the present study, we investigated the characteristics of SARS-CoV-2 within-host diversity of hu
Externí odkaz:
https://doaj.org/article/4854936a2f2a4d78944ee571bfcc343f
Autor:
Shaoji Cheng, Giuseppe Fleres, Liang Chen, Guojun Liu, Binghua Hao, Anthony Newbrough, Eileen Driscoll, Ryan K. Shields, Kevin M. Squires, Ting-yu Chu, Barry N. Kreiswirth, M. Hong Nguyen, Cornelius J. Clancy
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT It is unknown whether bacterial bloodstream infections (BSIs) are commonly caused by single organisms or mixed microbial populations. We hypothesized that contemporaneous carbapenem-resistant Klebsiella pneumoniae (CRKP) strains from blood c
Externí odkaz:
https://doaj.org/article/8bba3d1e7b134705bbfe1806872b7622
Publikováno v:
Viruses, Vol 15, Iss 5, p 1065 (2023)
The COVID-19 pandemic caused by SARS-CoV-2 has had a severe impact on people worldwide. The reference genome of the virus has been widely used as a template for designing mRNA vaccines to combat the disease. In this study, we present a computational
Externí odkaz:
https://doaj.org/article/2742f98bbe914b979b5863aad0d20dd9
Autor:
Jessica E. Agius, Jessica C. Johnson-Mackinnon, Winkie Fong, Mailie Gall, Connie Lam, Kerri Basile, Jen Kok, Alicia Arnott, Vitali Sintchenko, Rebecca J. Rockett
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
BackgroundLow frequency intrahost single nucleotide variants (iSNVs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been increasingly recognised as predictive indicators of positive selection. Particularly as growing numbers of
Externí odkaz:
https://doaj.org/article/9e3cfd6308464cbe9868341a704089b8
Autor:
Elikplim A. Amegashie, Lucas Amenga-Etego, Courage Adobor, Peter Ogoti, Kevin Mbogo, Alfred Amambua-Ngwa, Anita Ghansah
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-14 (2020)
Abstract Background Extensive genetic diversity in the Plasmodium falciparum circumsporozoite protein (PfCSP) is a major contributing factor to the moderate efficacy of the RTS,S/AS01 vaccine. The transmission intensity and rates of recombination wit
Externí odkaz:
https://doaj.org/article/c78a4aa7f24942fe993fe0a51f072837
Autor:
Fermin Acosta, Miguel Martínez-Lirola, Pedro J. Sola-Campoy, Jon Sicilia, Teresa Guerra-Galán, Sandra R. Maus, Patricia Muñoz, Laura Pérez-Lago, Darío García de Viedma
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT Genotyping tools help identify the complexity in Mycobacterium tuberculosis transmission clusters. We carried out a thorough analysis of the epidemiological and bacteriological complexity of a cluster in Almería, Spain. The cluster, initial
Externí odkaz:
https://doaj.org/article/3aac67ada43341b5a10fedc572a481d2
Autor:
Angela M. Early, Rachel F. Daniels, Timothy M. Farrell, Jonna Grimsby, Sarah K. Volkman, Dyann F. Wirth, Bronwyn L. MacInnis, Daniel E. Neafsey
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-13 (2019)
Abstract Background Deep sequencing of targeted genomic regions is becoming a common tool for understanding the dynamics and complexity of Plasmodium infections, but its lower limit of detection is currently unknown. Here, a new amplicon analysis too
Externí odkaz:
https://doaj.org/article/0b7d53446f924221baaa4bcc26a12031
Publikováno v:
Viruses, Vol 14, Iss 3, p 554 (2022)
Within-host viral diversity offers a view into the early stages of viral evolution occurring after a virus infects a host. In recent years, advances in deep sequencing have allowed for routine identification of low-frequency variants, which are impor
Externí odkaz:
https://doaj.org/article/2c7c65e787694b369883c754b2f75649