Výsledky vyhledávání - "Wishrawana Sarathi Ratnayake"

Abstract 150: Prevalent PKC-ι/ζ signaling is crucial for apoptosis inhibition and invasiveness of glioblastoma through upregulation of Pdk1/Akt1/14-3-3 cascade and Smad2/3

Autor: Wishrawana Sarathi Ratnayake, Khandker M. Khalid, Sloan Breedy, Luke Lajmi, Tracess Smalley, Christopher A. Apostolatos, Robert Hill, James Fackrell, Mildred Acevedo-Duncan

Publikováno v: Cancer Research. 82:150-150

Glioblastoma (GB) is an aggressive form of cancer derived from astrocytes and often found in brain or spinal cord. Poor prognosis of GB has limitations in current therapeutics mainly due to the development of resistance. Our results demonstrated that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::679d60b2e25296c6eb85b2f07a271a37
https://doi.org/10.1158/1538-7445.am2022-150

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Abstract 244: Inhibition of atypical PKC signaling enhances the sensitivity of glioblastoma cells towards Temozolomide therapy

Autor: Avijit Dey, Rekha Patel, Tracess Smalley, Wishrawana Sarathi Ratnayake, Anisul Islam, Mildred Acevedo-Duncan

Publikováno v: Cancer Research. 79:244-244

Glioblastoma is a highly aggressive brain cancer which has a mean survival rate of only 12 months. Current treatment options of glioblastoma include chemotherapy and limited surgical resection. Temozolomide (TMZ) is the current therapeutic choice for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c84e3f5402614a8236ee0e5634add3e9
https://doi.org/10.1158/1538-7445.am2019-244

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Abstract 2857: Vimentin is a novel PKC-ι target facilitating migration and invasion in melanoma

Autor: Wishrawana Sarathi Ratnayake, Sloan Breedy, Christopher Apostolatos, Robert Hill, Clare Dennison, Mildred Acevedo-Duncan

Publikováno v: Cancer Research. 79:2857-2857

Vimentin plays an important role in gaining rear-to-front polarity for mesenchymal cells, making it a hallmark of cancer metastasis. Epithelial-mesenchymal transition (EMT) is a vital process in tumor progression that converts stationary epithelial c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3088b03fbae40307ee28abf7b53c8eb8
https://doi.org/10.1158/1538-7445.am2019-2857

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Abstract 5204: ICAM-1 and IL-17E upregulate FOXO1 to suppress the expression of oncogenic PKC-ι in human melanoma

Autor: Wishrawana Sarathi Ratnayake, Christopher Apostolatos, Sloan Breedy, André Apostolatos, Mildred Acevedo-Duncan

Publikováno v: Cancer Research. 79:5204-5204

Throughout the span of the last 15 years, the number of cases of melanoma has been on a steady increase. Approximately, 92,000 new melanoma cases will be diagnosed in the United States in 2018. Our previous studies demonstrated that protein kinase C-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23dfa4788938212a3475867e6bc86e66
https://doi.org/10.1158/1538-7445.am2019-5204

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Abstract 1044: PKC-ι and PKC-ζ are heavily responsible of up-regulating epithelial-mesenchymal transition (EMT) and activating Vimentin to facilitate cellular motility in prostate cancer cell lines

Autor: Wishrawana Sarathi Ratnayake, Christopher Apostolatos, Sloan Breedy, Robert Hill, Clare Dennison, Mildred Acevedo-Duncan

Publikováno v: Cancer Research. 79:1044-1044

Prostate carcinoma is the most common cancer among men in terms of number of new cases reported each year. Approximately 26,000 deaths reported in 2018 in the United States and tumor metastasis is responsible for more than 90% of these deaths. Expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11b87a9f917379f7e6dccd661d6d8fe2
https://doi.org/10.1158/1538-7445.am2019-1044

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