Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Wishrawana S. Ratnayake"'
Autor:
Christopher A. Apostolatos, Wishrawana S. Ratnayake, Sloan Breedy, Jacqueline Kai Chin Chuah, James Alastair Miller, Daniele Zink, Marie Bourgeois, Mildred Acevedo-Duncan
Publikováno v:
Drugs and Drug Candidates, Vol 3, Iss 2, Pp 368-379 (2024)
Protein kinase C-iota (PKC-ι) is an oncogene overexpressed in many cancer cells including prostate, breast, ovarian, melanoma, and glioma cells. Previous in vitro studies have shown that 5-amino-1-((1R,2S,3R,4R)-2-3-dihydroxy-4-(hydroxymethyl)cyclop
Externí odkaz:
https://doaj.org/article/1824df5ae6f9488594a24a1a75f2bc46
Autor:
Khandker Mohammad Khalid, Wishrawana S. Ratnayake, Christopher A. Apostolatos, Mildred Acevedo-Duncan
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
BackgroundRenal Cell Carcinoma (RCC) is the most common type of kidney cancer (85%). 75% of the RCC cases involve conventional clear cell RCC (ccRCC). Approximately, 39% of late-stage patients (stage IV) are treated with chemotherapeutic agents. Phos
Externí odkaz:
https://doaj.org/article/4e36e424476d41c5accfad41adc37d21
Autor:
Wishrawana S. Ratnayake, Christopher A. Apostolatos, Sloan Breedy, Clare L. Dennison, Robert Hill, Mildred Acevedo-Duncan
Publikováno v:
Cell Adhesion & Migration, Vol 15, Iss 1, Pp 37-57 (2021)
Atypical protein kinase C (aPKC) are involved in progression of many human cancers. Vimentin is expressed during epithelial to mesenchymal transition (EMT). Molecular dynamics of Vimentin intermediate filaments (VIFs) play a key role in metastasis. T
Externí odkaz:
https://doaj.org/article/80dd4008f3894e1fbffe3bfd1f7b3d74
Publikováno v:
Cancer Research. 83:344-344
Medulloblastoma is the second most common childhood cancer, behind leukemia, and the most common pediatric brain tumor, comprising 20% of all childhood brain cancers. Our data demonstrated the effectiveness of atypical protein kinase C (aPKC) inhibit
Autor:
Khandker Mohammad Khalid, Wishrawana S. Ratnayake, Avijit Dey, Nuzhat N. Oishee, Mahfuza Marzan, Mildred Acevedo-Duncan
Publikováno v:
Cancer Research. 83:5025-5025
Glioblastoma (GBM) is characterized by poor therapeutic response and overall survival. It is the most aggressive form of primary brain tumor with a tendency to invade surrounding healthy brain tissues, rendering them largely incurable. In this study,
Publikováno v:
Cancer Research. 83:2555-2555
Neuroblastoma (NB) is a cancer that develops in the neuroblasts. It is the most common cancer in children under the age of 1 year, accounting for approximately 6% of all cancers. The prognosis of NB is linked to both age and degree of cell differenti
Autor:
Samer S. Sansil, Christopher Apostolatos, Anthony Neuger, Mildred Acevedo-Duncan, Wishrawana S. Ratnayake, Andre H. Apostolatos, Marie Bourgeois
Publikováno v:
Anti-Cancer Drugs
Protein kinase C-iota (PKC-ι) is an oncogene overexpressed in many cancer cells including prostate, breast, ovarian, melanoma, and glioma. Previous in-vitro studies have shown that 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imida
Autor:
Khandker Mohammad Khalid, Wishrawana S. Ratnayake, Christopher A. Apostolatos, Luke Lajmi, Sloan Breedy, Nuzhat N. Oishee, Mildred Acevedo-Duncan
Publikováno v:
Cancer Research. 82:158-158
Renal Cell Carcinoma (RCC) is the most common type of kidney cancer (85%) of which 75% of the cases involve conventional clear cell RCC (ccRCC). Choice of treatments recommended for clear cell carcinoma and non-clear cell carcinoma are partial nephre
Publikováno v:
Cancer Research. 82:172-172
Medulloblastoma is the most common pediatric brain tumor, constituting 20% of all childhood brain cancers (Clin. Cancer Res. 2008, 14 (4), 971-976., Oncogenesis 2019, 8 (11), 1-11). It is a highly invasive tumor that originates in the cerebellum and
Publikováno v:
World Academy of Sciences Journal.