Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Wisely Oki Sugiarto"'
Autor:
Patrick L. Purder, Christian Meyners, Wisely Oki Sugiarto, Jürgen Kolos, Frank Löhr, Jakob Gebel, Thomas Nehls, Volker Dötsch, Frederik Lermyte, Felix Hausch
Publikováno v:
JACS Au, Vol 3, Iss 9, Pp 2478-2486 (2023)
Externí odkaz:
https://doaj.org/article/8984322cf97846e88f94062743ef5104
Autor:
Fabian H. Knaup, Christian Meyners, Wisely Oki Sugiarto, Saskia Wedel, Margherita Springer, Carlo Walz, Thomas M. Geiger, Mathias Schmidt, Marco Sisignano, Felix Hausch
In recent years the selective inhibition of FKBP51 has emerged as a possible treatment for chronic pain, obesity-induced diabetes, or depression. All currently known advanced FKBP51-selective inhibitors, including the widely used SAFit2, contain a cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03081ad8bb2b0f20e4cbea12ac38d678
https://doi.org/10.26434/chemrxiv-2023-pzzcv
https://doi.org/10.26434/chemrxiv-2023-pzzcv
Autor:
Wisely Oki Sugiarto, Frank Kirschhöfer, Charlotte Desczyk, Matthias Ballweg, Aleksandra Kopranovic, Franz-Josef Meyer-Almes, Marius Muth, Niklas Jänsch, Gerald Brenner-Weiss
Publikováno v:
Chemistry-a European journal, 26 (58), 13249-13255
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry (Weinheim an Der Bergstrasse, Germany)
Human histone deacetylase 8 is a well‐recognized target for T‐cell lymphoma and particularly childhood neuroblastoma. PD‐404,182 was shown to be a selective covalent inhibitor of HDAC8 that forms mixed disulfides with several cysteine residues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d90238a97d5741dff143a274b728ac1
https://doi.org/10.1002/chem.202001712
https://doi.org/10.1002/chem.202001712
Publikováno v:
Biological Chemistry. 400:733-743
Histone deacetylase 8 (HDAC8) is an established and validated target for T-cell lymphoma and childhood neuroblastoma. The active site binding pocket of HDAC8 is highly conserved among all zinc-containing representatives of the histone deacetylase (HD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcf28a97a7c48a83f2be7d56458f5bf
https://doi.org/10.1515/hsz-2018-0363
https://doi.org/10.1515/hsz-2018-0363
Autor:
Stephanie Merz, Felix Hausch, Andreas M. Voll, Patrick L. Purder, Wisely Oki Sugiarto, Michael Bauder, Tim Heymann, Christian Meyners
Publikováno v:
Journal of medicinal chemistry. 64(6)
The FK506-binding protein 51 (FKBP51) emerged as a key player in several diseases like stress-related disorders, chronic pain, and obesity. Linear analogues of FK506 called SAFit were shown to be highly selective for FKBP51 over its closest homologue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07383e4fa788acd0ddb9b755aae709d
https://pubmed.ncbi.nlm.nih.gov/33666419
https://pubmed.ncbi.nlm.nih.gov/33666419
Autor:
Niklas Jänsch, Rabia Altintas, Benjamin Wolff, Maraike Lang, Franz-Josef Meyer-Almes, Stefan Frühschulz, Wisely Oki Sugiarto, Ina Oehme
Publikováno v:
European journal of medicinal chemistry. 184
Human histone deacetylase 8 (HDAC8) is a highly promising target for neuroblastoma and other types of cancer. Several HDAC inhibitors are approved for the treatment of special cancer subtypes or are evaluated in clinical trials. By far the most drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95cf34f0c7bff44a15eddbdf25902ba8
https://pubmed.ncbi.nlm.nih.gov/31630054
https://pubmed.ncbi.nlm.nih.gov/31630054