Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Wiro M.B.P. Menge"'
Autor:
Willem F.J. Karstens, Wiro M.B.P. Menge, Gijs Martens, Sanne J.N. op het Veld, Jacobus Th.H. van Eupen, Marco Demon, Tanja A.E. van Achterberg, Monica J. Arisse-Thijssen, Ellen W.H. Santegoeds-Lenssen, Miranda M.C. van der Lee, Ruud Ubink, Roel J. Arends, Aloys Sesink, Marion Blomenröhr, C. Marco Timmers
Publikováno v:
Bioorganic & Medicinal Chemistry. 84:117258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9787cb372820a3d11bdca44ad495a1f2
https://doi.org/10.1016/j.bmc.2023.117258
https://doi.org/10.1016/j.bmc.2023.117258
Autor:
Hendrik Timmerman, Martin Tulp, Rob Leurs, Martin J.P. Adolfs, Obbe P. Zuiderveld, Wiro M.B.P. Menge
Publikováno v:
British Journal of Pharmacology. 116:2315-2321
1. In the present study we evaluated the receptor selectivity of the potent histamine H3 receptor antagonist, iodophenpropit (IPP) in comparison with the prototype antagonist, thioperamide. 2. IPP proved to be a potent competitive H3 receptor antagon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4c7c63226decf1487905989a57351f
https://doi.org/10.1111/j.1476-5381.1995.tb15071.x
https://doi.org/10.1111/j.1476-5381.1995.tb15071.x
Autor:
Rogier A. Smits, Wiro M.B.P. Menge, Remko A. Bakker, Andrea C. van de Stolpe, Aldo Jongejan, Enade Perdana Istyastono, Silvia Gobbi, Obbe P. Zuiderveld, Roger Lahaye, Eric E. J. Haaksma, Giuseppe Romeo, Herman D. Lim, Rob Leurs, Marjo Schepers, Iwan J. P. de Esch
Publikováno v:
Lim, H D, Istyastono, E P, van de Stolpe, A, Romeo, G, Gobbi, S, Schepers, M, Lahaye, R, Menge, W M, Zuiderveld, O P, Jongejan, A, Smits, R A, Bakker, R A, Haaksma, E E, Leurs, R & de Esch, I J P 2009, ' Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies ', Bioorganic and Medicinal Chemistry, vol. 17, no. 11, pp. 3987-94 . https://doi.org/10.1016/j.bmc.2009.04.007
Bioorganic and Medicinal Chemistry, 17(11), 3987-94. Elsevier Limited
Bioorganic and Medicinal Chemistry, 17(11), 3987-94. Elsevier Limited
Previous studies have demonstrated that clobenpropit (N-(4-chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea) binds to both the human histamine H(3) receptor (H(3)R) and H(4) receptor (H(4)R). In this paper, we describe the synthesis and pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e609353f2f5a5bd94d77dc3b443eda7
http://hdl.handle.net/20.500.11769/38416
http://hdl.handle.net/20.500.11769/38416
Autor:
Sigurd Elz, Martine J. Smit, Henk Timmerman, Wiro M.B.P. Menge, Rob Leurs, Ineke van de Wetering, Remko A. Bakker, Marinella Govoni, Schickaneder Helmut
Publikováno v:
Govoni, M, Bakker, R A, van de Wetering, I, Smit, M J, Menge, W M P B, Timmerman, H, Elz, S, Schunack, W & Leurs, R 2003, ' Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists ', Journal of Medicinal Chemistry, vol. 46, no. 26, pp. 5812-24 . https://doi.org/10.1021/jm030936t
Journal of Medicinal Chemistry, 46(26), 5812-24. American Chemical Society
Journal of Medicinal Chemistry, 46(26), 5812-24. American Chemical Society
In the present study we searched for neutral antagonists for the human histamine H(1)-receptor (H(1)R) by screening newly synthesized ligands that are structurally related to H(1)R agonists for their affinity using radioligand displacement studies an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485a8ceac2af8c6d7acf93f77bee5c25
https://research.vu.nl/en/publications/68a25934-5e92-45bf-9951-967b7553a1d1
https://research.vu.nl/en/publications/68a25934-5e92-45bf-9951-967b7553a1d1
Publikováno v:
British journal of pharmacology. 112(3)
1. The gene for the human histamine H2 receptor was stably expressed in Chinese hamster ovary (CHO) cells and characterized by [125I]-iodoaminopotentidine binding studies. In addition, the coupling of the expressed receptor protein to a variety of si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63f4086433684d2e0baa6d938d0013a
https://pubmed.ncbi.nlm.nih.gov/7921611
https://pubmed.ncbi.nlm.nih.gov/7921611