Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Autor: Denielli da Silva Gonçalves Bos, MSc, Chris Happé, MSc, Ingrid Schalij, BSc, Wioletta Pijacka, PhD, Julian F.R. Paton, PhD, Christophe Guignabert, PhD, Ly Tu, PhD, Raphaël Thuillet, BSc, Harm-Jan Bogaard, MD, PhD, Albert C. van Rossum, MD, PhD, Anton Vonk-Noordegraaf, MD, PhD, Frances S. de Man, PhD, M. Louis Handoko, MD, PhD

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 1, Pp 22-35 (2017)

Summary: Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept stud

Externí odkaz: https://doaj.org/article/e1692e835da34a7ebef7c44c7fc09f84

P2X3 receptor antagonism reduces the occurrence of apnoeas in newborn rats

Autor: Julian F. R. Paton, Helio Cesar Salgado, Anthony P.D.W. Ford, Pedro Lourenço Katayama, Joel R Gever, Ana Paula Abdala, Ian Charles, Wioletta Pijacka

Publikováno v: Respir Physiol Neurobiol

Hyperreflexia of the peripheral chemoreceptors is a potential contributor of apnoeas of prematurity (AoP). Recently, it was shown that elevated P2X3 receptor expression was associated with elevated carotid body afferent sensitivity. Therefore, we tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e714d2df7c4da29248334afa5618824
https://pubmed.ncbi.nlm.nih.gov/32259688

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Autor: Ly Tu, Frances S. de Man, Harm Jan Bogaard, Raphaël Thuillet, Julian F. R. Paton, M. Louis Handoko, Anton Vonk-Noordegraaf, Christophe Guignabert, Ingrid Schalij, Denielli da Silva Goncalves Bos, Chris Happé, Wioletta Pijacka, Albert C. van Rossum

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 1, Pp 22-35 (2017)
Jacc. Basic to Translational Science
da Silva Gonçalves Bos, D, Happé, C, Schalij, I, Pijacka, W, Paton, J F R, Guignabert, C, Tu, L, Thuillet, R, Bogaard, H J, van Rossum, A C, Vonk-Noordegraaf, A, de Man, F S & Handoko, M L 2017, ' Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension ', JACC: Basic to Translational Science, vol. 2, no. 1, pp. 22-35 . https://doi.org/10.1016/j.jacbts.2016.09.007
da Silva Gonçalves Bos, D, Happé, C, Schalij, I, Pijacka, W, Paton, J F R, Guignabert, C, Tu, L, Thuillet, R, Bogaard, H-J, van Rossum, A C, Vonk-Noordegraaf, A, de Man, F S & Handoko, M L 2017, ' Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension ', JACC: Basic to Translational Science, vol. 2, no. 1, pp. 22–35 . https://doi.org/10.1016/j.jacbts.2016.09.007
JACC: Basic to Translational Science, 2(1), 22-35. Elsevier Inc.

Visual Abstract
Highlights • Neurohormonal dysfunction (increased sympathetic nervous system and renin angiotensin-aldosterone system) play an important role in pulmonary hypertension progression. • In this proof-of-concept study we demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59b7f95f7fec99ad60098c33515947c
http://www.sciencedirect.com/science/article/pii/S2452302X16301668

Purinergic receptors in the carotid body as a new drug target for controlling hypertension

Autor: Wioletta Pijacka, Laura E K Ratcliffe, Emma C. Hart, Davi J. A. Moraes, Julian F. R. Paton, Angus K Nightingale, Anthony P.D.W. Ford, Fiona D McBryde, Melina P. da Silva, Benedito H. Machado, Ana Paula Abdala

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Pijacka, W, Moraes, D J D A, Ratcliffe, L E K, Nightingale, A K, Hart, E C J, da Silva, M, Machado, B, McBryde, F D, Abdala Sheikh, A P, Ford, A & Paton, J F R 2016, ' Purinergic receptors in the carotid body as a new drug target for controlling hypertension ', Nature Medicine, vol. 22, no. 10, pp. 1151-1159 . https://doi.org/10.1038/nm.4173

In view of the high proportion of individuals with resistance to antihypertensive medication and/or poor compliance or tolerance of this medication, new drugs to treat hypertension are urgently needed. Here we show that peripheral chemoreceptors gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638e04d9b0906003869f21d96269db97
https://doi.org/10.1038/nm.4173

Variable role of carotid bodies in cardiovascular responses to exercise, hypoxia and hypercapnia in spontaneously hypertensive rats

Autor: Wioletta, Pijacka, Pedro L, Katayama, Helio C, Salgado, Gisele S, Lincevicius, Ruy R, Campos, Fiona D, McBryde, Julian F R, Paton

Publikováno v: The Journal of physiology. 596(15)

Carotid bodies play a critical role in maintaining arterial pressure during hypoxia and this has important implications when considering resection therapy of the carotid body in disease states such as hypertension. Curbing hypertension in patients wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::16426d09fb943b2d2f39f5b598e58cf2
https://pubmed.ncbi.nlm.nih.gov/29388224