Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Wioletta Czaja"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract DNA alkylation damage induced by environmental carcinogens, chemotherapy drugs, or endogenous metabolites plays a central role in mutagenesis, carcinogenesis, and cancer therapy. Base excision repair (BER) is a conserved, front line DNA repa
Externí odkaz:
https://doaj.org/article/f1ba10e57c694615a5775bd8ddef661d
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9313 (2022)
Robust, tightly regulated DNA repair is critical to maintaining genome stability and preventing cancer. Eukaryotic DNA is packaged into chromatin, which has a profound, yet incompletely understood, regulatory influence on DNA repair and genome stabil
Externí odkaz:
https://doaj.org/article/39a3d963885f44918f0aa0b4af8e749d
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008632 (2020)
Transposable elements constitute a large fraction of most eukaryotic genomes. Insertion of mobile DNA sequences typically has deleterious effects on host fitness, and thus diverse mechanisms have evolved to control mobile element proliferation. Mobil
Externí odkaz:
https://doaj.org/article/1163b769c3f3435ca8cbad180c0b1cce
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 9, Pp 11954-11973 (2012)
DNA repair in eukaryotic cells takes place in the context of chromatin, where DNA, including damaged DNA, is tightly packed into nucleosomes and higher order chromatin structures. Chromatin intrinsically restricts accessibility of DNA repair proteins
Externí odkaz:
https://doaj.org/article/1cb569a8558c46388c13b8b0c86d1976
Autor:
SOUREN PAUL, Preston McCourt, Le Thi My Le, Joohyun Ryu, Wioletta Czaja, Ann Bode, Rafael Contreras-Galindo, zigang Dong
Telomeres protect chromosome ends and determine the proliferative potential of cells. The canonical telomere sequence TTAGGG is synthesized by telomerase holoenzyme, which maintains telomere length in proliferative stem cells. Although the core compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a0b77da5f7cd690a4ebcaa55cf1ec9e
https://doi.org/10.21203/rs.3.rs-1425640/v1
https://doi.org/10.21203/rs.3.rs-1425640/v1
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
DNA alkylation damage induced by environmental carcinogens, chemotherapy drugs, or endogenous metabolites plays a central role in mutagenesis, carcinogenesis, and cancer therapy. Base excision repair (BER) is a conserved, front line DNA repair pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74de855aa27a2b5d06f83fa38c08b10
https://doi.org/10.1038/s41598-021-97523-w
https://doi.org/10.1038/s41598-021-97523-w
Autor:
Wioletta Czaja, John J. Wyrick, Kathiresan Selvam, Amelia J. Hodges, Kaitlynne A. Bohm, Peng Mao, Michael J. Smerdon
Publikováno v:
Genome Res
Nucleosomes are a significant barrier to the repair of UV damage because they impede damage recognition by nucleotide excision repair (NER). The RSC and SWI/SNF chromatin remodelers function in cells to promote DNA access by moving or evicting nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be92d1ee91c8c3a685cb845dbd0a1b24
https://pubmed.ncbi.nlm.nih.gov/34001524
https://pubmed.ncbi.nlm.nih.gov/34001524
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 2, p e1008632 (2020)
PLoS Genetics, Vol 16, Iss 2, p e1008632 (2020)
Transposable elements constitute a large fraction of most eukaryotic genomes. Insertion of mobile DNA sequences typically has deleterious effects on host fitness, and thus diverse mechanisms have evolved to control mobile element proliferation. Mobil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80bc263ec2cac95d40d33f3c92a44d7
http://europepmc.org/articles/PMC7055915
http://europepmc.org/articles/PMC7055915
Insertion of mobile DNA sequences typically has deleterious effects on host fitness, and thus diverse mechanisms have evolved to control mobile element proliferation across the tree of life. Mobility of the Ty1 retrotransposon inSaccharomycesyeasts i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62329e5088418f4fff19e5c3bf406e79
Autor:
Thomas B. Thompson, DM DeAvila, Buel D. Rodgers, Wioletta Czaja, Jennifer A. Eldridge, Naisi Li, Yukiko K. Nakamura
Publikováno v:
Am J Physiol Endocrinol Metab
Circulating myostatin-attenuating agents are being developed to treat muscle-wasting disease despite their potential to produce serious off-target effects, as myostatin/activin receptors are widely distributed among many nonmuscle tissues. Our studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e1d15c07bd23657fa7cd4cd12eca60
https://europepmc.org/articles/PMC6620572/
https://europepmc.org/articles/PMC6620572/